Toll-Like Receptor 3
"Toll-Like Receptor 3" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A pattern recognition receptor that binds DOUBLE-STRANDED RNA. It mediates cellular responses to certain viral pathogens.
Descriptor ID |
D051196
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MeSH Number(s) |
D12.776.543.750.705.910.500.300
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Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Toll-Like Receptor 3".
Below are MeSH descriptors whose meaning is more specific than "Toll-Like Receptor 3".
This graph shows the total number of publications written about "Toll-Like Receptor 3" by people in this website by year, and whether "Toll-Like Receptor 3" was a major or minor topic of these publications.
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Year | Major Topic | Minor Topic | Total |
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2003 | 0 | 3 | 3 | 2004 | 0 | 2 | 2 | 2005 | 1 | 6 | 7 | 2006 | 2 | 0 | 2 | 2007 | 0 | 2 | 2 | 2008 | 0 | 3 | 3 | 2009 | 3 | 0 | 3 | 2010 | 1 | 0 | 1 | 2011 | 2 | 1 | 3 | 2013 | 2 | 0 | 2 | 2014 | 1 | 0 | 1 | 2015 | 2 | 0 | 2 |
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Below are the most recent publications written about "Toll-Like Receptor 3" by people in Profiles.
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Duffau P, Menn-Josephy H, Cuda CM, Dominguez S, Aprahamian TR, Watkins AA, Yasuda K, Monach P, Lafyatis R, Rice LM, Kenneth Haines G, Gravallese EM, Baum R, Richez C, Perlman H, Bonegio RG, Rifkin IR. Promotion of Inflammatory Arthritis by Interferon Regulatory Factor 5 in a Mouse Model. Arthritis Rheumatol. 2015 Dec; 67(12):3146-57.
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Kang S, Fernandes-Alnemri T, Rogers C, Mayes L, Wang Y, Dillon C, Roback L, Kaiser W, Oberst A, Sagara J, Fitzgerald KA, Green DR, Zhang J, Mocarski ES, Alnemri ES. Caspase-8 scaffolding function and MLKL regulate NLRP3 inflammasome activation downstream of TLR3. Nat Commun. 2015 Jun 24; 6:7515.
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Hartwell HJ, Petrosky KY, Fox JG, Horseman ND, Rogers AB. Prolactin prevents hepatocellular carcinoma by restricting innate immune activation of c-Myc in mice. Proc Natl Acad Sci U S A. 2014 Aug 5; 111(31):11455-60.
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Wochal P, Rathinam VA, Dunne A, Carlson T, Kuang W, Seidl KJ, Hall JP, Lin LL, Collins M, Schattgen SA, MacKay CR, Fagundes CT, Carpenter S, Fitzgerald KA, O'Neill LA. TRIL is involved in cytokine production in the brain following Escherichia coli infection. J Immunol. 2014 Aug 15; 193(4):1911-9.
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Alkanani AK, Hara N, Lien E, Ir D, Kotter CV, Robertson CE, Wagner BD, Frank DN, Zipris D. Induction of diabetes in the RIP-B7.1 mouse model is critically dependent on TLR3 and MyD88 pathways and is associated with alterations in the intestinal microbiome. Diabetes. 2014 Feb; 63(2):619-31.
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Schamber-Reis BL, Petritus PM, Caetano BC, Martinez ER, Okuda K, Golenbock D, Scott P, Gazzinelli RT. UNC93B1 and nucleic acid-sensing Toll-like receptors mediate host resistance to infection with Leishmania major. J Biol Chem. 2013 Mar 08; 288(10):7127-36.
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Johnsen IB, Nguyen TT, Bergstrøm B, Lien E, Anthonsen MW. Toll-like receptor 3-elicited MAPK activation induces stabilization of interferon-ß mRNA. Cytokine. 2012 Mar; 57(3):337-46.
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Caetano BC, Carmo BB, Melo MB, Cerny A, dos Santos SL, Bartholomeu DC, Golenbock DT, Gazzinelli RT. Requirement of UNC93B1 reveals a critical role for TLR7 in host resistance to primary infection with Trypanosoma cruzi. J Immunol. 2011 Aug 15; 187(4):1903-11.
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Siednienko J, Gajanayake T, Fitzgerald KA, Moynagh P, Miggin SM. Absence of MyD88 results in enhanced TLR3-dependent phosphorylation of IRF3 and increased IFN-ß and RANTES production. J Immunol. 2011 Feb 15; 186(4):2514-22.
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Siednienko J, Halle A, Nagpal K, Golenbock DT, Miggin SM. TLR3-mediated IFN-ß gene induction is negatively regulated by the TLR adaptor MyD88 adaptor-like. Eur J Immunol. 2010 Nov; 40(11):3150-60.
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