Mitogen-Activated Protein Kinase 14

"Mitogen-Activated Protein Kinase 14" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A 38-kDa mitogen-activated protein kinase that is abundantly expressed in a broad variety of cell types. It is involved in the regulation of cellular stress responses as well as the control of proliferation and survival of many cell types. The kinase activity of the enzyme is inhibited by the pyridinyl-imidazole compound SB 203580.

Descriptor ID	D048308
MeSH Number(s)	D08.811.913.696.620.682.700.567.843.937 D12.644.360.450.835.800 D12.776.476.450.835.937
Concept/Terms	Mitogen-Activated Protein Kinase 14 Mitogen-Activated Protein Kinase 14 Mitogen Activated Protein Kinase 14 CSAID-Binding Protein CSAID Binding Protein Kinase CSBP CSBP, Kinase p38alpha MAP Kinase MAP Kinase, p38alpha p38alphaMAPK Cytokine Suppressive Anti-inflammatory Drug Binding Protein Cytokine Suppressive Anti inflammatory Drug Binding Protein Mxi2 Protein MAX-Interacting Protein 2 MAX Interacting Protein 2 p38alpha Mitogen-Activated Protein Kinase p38alpha Mitogen Activated Protein Kinase MAPK14 Stress-activated protein kinase 2a Stress activated protein kinase 2a SAPK2a MAPK14 Mitogen-Activated Protein Kinase MAPK14 Mitogen Activated Protein Kinase

Below are MeSH descriptors whose meaning is more general than "Mitogen-Activated Protein Kinase 14".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Transferases [D08.811.913]
Phosphotransferases [D08.811.913.696]
Phosphotransferases (Alcohol Group Acceptor) [D08.811.913.696.620]
Protein Kinases [D08.811.913.696.620.682]
Protein-Serine-Threonine Kinases [D08.811.913.696.620.682.700]
Mitogen-Activated Protein Kinases [D08.811.913.696.620.682.700.567]
p38 Mitogen-Activated Protein Kinases [D08.811.913.696.620.682.700.567.843]
Mitogen-Activated Protein Kinase 14 [D08.811.913.696.620.682.700.567.843.937]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intracellular Signaling Peptides and Proteins [D12.644.360]
Mitogen-Activated Protein Kinases [D12.644.360.450]
p38 Mitogen-Activated Protein Kinases [D12.644.360.450.835]
Mitogen-Activated Protein Kinase 14 [D12.644.360.450.835.800]
Proteins [D12.776]
Intracellular Signaling Peptides and Proteins [D12.776.476]
Mitogen-Activated Protein Kinases [D12.776.476.450]
p38 Mitogen-Activated Protein Kinases [D12.776.476.450.835]
Mitogen-Activated Protein Kinase 14 [D12.776.476.450.835.937]

Below are MeSH descriptors whose meaning is related to "Mitogen-Activated Protein Kinase 14".

Below are MeSH descriptors whose meaning is more specific than "Mitogen-Activated Protein Kinase 14".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Mitogen-Activated Protein Kinase 14" by people in this website by year, and whether "Mitogen-Activated Protein Kinase 14" was a major or minor topic of these publications.

Bar chart showing 7 publications over 5 distinct years, with a maximum of 2 publications in 2010 and 2014

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2007	1	0	1
2010	1	1	2
2011	0	1	1
2014	2	0	2
2016	1	0	1

Below are the most recent publications written about "Mitogen-Activated Protein Kinase 14" by people in Profiles.

Haldane A, Flynn WF, He P, Vijayan RS, Levy RM. Structural propensities of kinase family proteins from a Potts model of residue co-variation. Protein Sci. 2016 08; 25(8):1378-84.

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Greenblatt MB, Kim JM, Oh H, Park KH, Choo MK, Sano Y, Tye CE, Skobe Z, Davis RJ, Park JM, Bei M, Glimcher LH, Shim JH. p38a MAPK is required for tooth morphogenesis and enamel secretion. J Biol Chem. 2015 Jan 02; 290(1):284-95.

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Waterworth DM, Li L, Scott R, Warren L, Gillson C, Aponte J, Sarov-Blat L, Sprecher D, Dupuis J, Reiner A, Psaty BM, Tracy RP, Lin H, McPherson R, Chissoe S, Wareham N, Ehm MG. A low-frequency variant in MAPK14 provides mechanistic evidence of a link with myeloperoxidase: a prognostic cardiovascular risk marker. J Am Heart Assoc. 2014 Aug 27; 3(4).

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Tang WH, Stitham J, Gleim S, Di Febbo C, Porreca E, Fava C, Tacconelli S, Capone M, Evangelista V, Levantesi G, Wen L, Martin K, Minuz P, Rade J, Patrignani P, Hwa J. Glucose and collagen regulate human platelet activity through aldose reductase induction of thromboxane. J Clin Invest. 2011 Nov; 121(11):4462-76.

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Ahn YM, Clare M, Ensinger CL, Hood MM, Lord JW, Lu WP, Miller DF, Patt WC, Smith BD, Vogeti L, Kaufman MD, Petillo PA, Wise SC, Abendroth J, Chun L, Clark R, Feese M, Kim H, Stewart L, Flynn DL. Switch control pocket inhibitors of p38-MAP kinase. Durable type II inhibitors that do not require binding into the canonical ATP hinge region. Bioorg Med Chem Lett. 2010 Oct 01; 20(19):5793-8.

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Greenblatt MB, Shim JH, Zou W, Sitara D, Schweitzer M, Hu D, Lotinun S, Sano Y, Baron R, Park JM, Arthur S, Xie M, Schneider MD, Zhai B, Gygi S, Davis R, Glimcher LH. The p38 MAPK pathway is essential for skeletogenesis and bone homeostasis in mice. J Clin Invest. 2010 Jul; 120(7):2457-73.

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Kennedy NJ, Cellurale C, Davis RJ. A radical role for p38 MAPK in tumor initiation. Cancer Cell. 2007 Feb; 11(2):101-3.

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Aouadi M, Laurent K, Prot M, Le Marchand-Brustel Y, Bin?truy B, Bost F. Inhibition of p38MAPK increases adipogenesis from embryonic to adult stages. Diabetes. 2006 Feb; 55(2):281-9.

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