Transforming Growth Factor beta1

"Transforming Growth Factor beta1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A subtype of transforming growth factor beta that is synthesized by a wide variety of cells. It is synthesized as a precursor molecule that is cleaved to form mature TGF-beta 1 and TGF-beta1 latency-associated peptide. The association of the cleavage products results in the formation a latent protein which must be activated to bind its receptor. Defects in the gene that encodes TGF-beta1 are the cause of CAMURATI-ENGELMANN SYNDROME.

Descriptor ID	D053773
MeSH Number(s)	D12.644.276.374.687.100 D12.644.276.954.775.100 D12.776.467.374.687.100 D12.776.467.942.775.100 D23.529.374.687.100 D23.529.942.775.100
Concept/Terms	Transforming Growth Factor beta1 Transforming Growth Factor beta1 TGF-beta1 Transforming Growth Factor beta I TGF-beta-1 TGF beta 1 Transforming Growth Factor beta 1 Latency Associated Peptide Transforming Growth Factor beta 1 Latency Associated Peptide TGF-beta1 Latency-Associated Protein Latency-Associated Protein, TGF-beta1 TGF beta1 Latency Associated Protein TGF-beta1LAP TGF beta1LAP

Below are MeSH descriptors whose meaning is more general than "Transforming Growth Factor beta1".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intercellular Signaling Peptides and Proteins [D12.644.276]
Cytokines [D12.644.276.374]
Transforming Growth Factor beta [D12.644.276.374.687]
Transforming Growth Factor beta1 [D12.644.276.374.687.100]
TGF-beta Superfamily Proteins [D12.644.276.954]
Transforming Growth Factor beta [D12.644.276.954.775]
Transforming Growth Factor beta1 [D12.644.276.954.775.100]
Proteins [D12.776]
Intercellular Signaling Peptides and Proteins [D12.776.467]
Cytokines [D12.776.467.374]
Transforming Growth Factor beta [D12.776.467.374.687]
Transforming Growth Factor beta1 [D12.776.467.374.687.100]
TGF-beta Superfamily Proteins [D12.776.467.942]
Transforming Growth Factor beta [D12.776.467.942.775]
Transforming Growth Factor beta1 [D12.776.467.942.775.100]
Biological Factors [D23]
Intercellular Signaling Peptides and Proteins [D23.529]
Cytokines [D23.529.374]
Transforming Growth Factor beta [D23.529.374.687]
Transforming Growth Factor beta1 [D23.529.374.687.100]
TGF-beta Superfamily Proteins [D23.529.942]
Transforming Growth Factor beta [D23.529.942.775]
Transforming Growth Factor beta1 [D23.529.942.775.100]

Below are MeSH descriptors whose meaning is related to "Transforming Growth Factor beta1".

Below are MeSH descriptors whose meaning is more specific than "Transforming Growth Factor beta1".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Transforming Growth Factor beta1" by people in this website by year, and whether "Transforming Growth Factor beta1" was a major or minor topic of these publications.

Bar chart showing 34 publications over 15 distinct years, with a maximum of 5 publications in 2008

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2004	0	1	1
2005	0	2	2
2007	1	0	1
2008	3	2	5
2009	2	0	2
2010	1	0	1
2011	1	3	4
2012	0	4	4
2013	2	1	3
2014	0	2	2
2015	3	1	4
2016	0	2	2
2017	0	1	1
2020	0	1	1
2021	0	1	1

Below are the most recent publications written about "Transforming Growth Factor beta1" by people in Profiles.

Li FJ, Surolia R, Li H, Wang Z, Liu G, Kulkarni T, Massicano AVF, Mobley JA, Mondal S, de Andrade JA, Coonrod SA, Thompson PR, Wille K, Lapi SE, Athar M, Thannickal VJ, Carter AB, Antony VB. Citrullinated vimentin mediates development and progression of lung fibrosis. Sci Transl Med. 2021 03 17; 13(585).

View in: PubMed
van der Velden JL, Alcorn JF, Chapman DG, Lundblad LKA, Irvin CG, Davis RJ, Butnor K, Janssen-Heininger YMW. Airway epithelial specific deletion of Jun-N-terminal kinase 1 attenuates pulmonary fibrosis in two independent mouse models. PLoS One. 2020; 15(1):e0226904.

View in: PubMed
Druhan LJ, Lance A, Li S, Price AE, Emerson JT, Baxter SA, Gerber JM, Avalos BR. Leucine Rich a-2 Glycoprotein: A Novel Neutrophil Granule Protein and Modulator of Myelopoiesis. PLoS One. 2017; 12(1):e0170261.

View in: PubMed
Fan J, Yang MX, Ouyang Q, Fu D, Xu Z, Liu X, Mino-Kenudson M, Geng J, Tang F. Phosphatase PPM1A is a novel prognostic marker in pancreatic ductal adenocarcinoma. Hum Pathol. 2016 09; 55:151-8.

View in: PubMed
von Gise A, Stevens SM, Honor LB, Oh JH, Gao C, Zhou B, Pu WT. Contribution of Fetal, but Not Adult, Pulmonary Mesothelium to Mesenchymal Lineages in Lung Homeostasis and Fibrosis. Am J Respir Cell Mol Biol. 2016 Feb; 54(2):222-30.

View in: PubMed
Kural MH, Billiar KL. Myofibroblast persistence with real-time changes in boundary stiffness. Acta Biomater. 2016 Mar 01; 32:223-230.

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Lewandowski SL, Janardhan HP, Trivedi CM. Histone Deacetylase 3 Coordinates Deacetylase-independent Epigenetic Silencing of Transforming Growth Factor-?1 (TGF-?1) to Orchestrate Second Heart Field Development. J Biol Chem. 2015 Nov 06; 290(45):27067-27089.

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Zhang X, Wu H, Dobson JR, Browne G, Hong D, Akech J, Languino LR, Stein GS, Lian JB. Expression of the IL-11 Gene in Metastatic Cells Is Supported by Runx2-Smad and Runx2-cJun Complexes Induced by TGF?1. J Cell Biochem. 2015 Sep; 116(9):2098-108.

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He X, Xie J, Zhang D, Su Q, Sai X, Bai R, Chen C, Luo X, Gao G, Pan W. Recombinant adeno-associated virus-mediated inhibition of microRNA-21 protects mice against the lethal schistosome infection by repressing both IL-13 and transforming growth factor beta 1 pathways. Hepatology. 2015 Jun; 61(6):2008-2017.

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Hjortnaes J, Camci-Unal G, Hutcheson JD, Jung SM, Schoen FJ, Kluin J, Aikawa E, Khademhosseini A. Directing valvular interstitial cell myofibroblast-like differentiation in a hybrid hydrogel platform. Adv Healthc Mater. 2015 Jan 07; 4(1):121-30.

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