RNA, Messenger

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"RNA, Messenger" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.

Descriptor ID	D012333
MeSH Number(s)	D13.444.735.544
Concept/Terms	RNA, Messenger RNA, Messenger mRNA Messenger RNA RNA, Polyadenylated RNA, Polyadenylated Polyadenylated RNA Poly(A) RNA Poly(A)+ RNA Poly(A) Tail Poly(A) Tail mRNA, Non-Polyadenylated mRNA, Non-Polyadenylated mRNA, Non Polyadenylated Non-Polyadenylated mRNA Non Polyadenylated mRNA mRNA, Polyadenylated mRNA, Polyadenylated RNA, Messenger, Polyadenylated Messenger RNA, Polyadenylated Polyadenylated Messenger RNA RNA, Polyadenylated Messenger Polyadenylated mRNA Poly(A)+ mRNA

Below are MeSH descriptors whose meaning is more general than "RNA, Messenger".

Chemicals and Drugs [D]
Nucleic Acids, Nucleotides, and Nucleosides [D13]
Nucleic Acids [D13.444]
RNA [D13.444.735]
RNA, Messenger [D13.444.735.544]

Below are MeSH descriptors whose meaning is related to "RNA, Messenger".

Below are MeSH descriptors whose meaning is more specific than "RNA, Messenger".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "RNA, Messenger" by people in this website by year, and whether "RNA, Messenger" was a major or minor topic of these publications.

Bar chart showing 1134 publications over 31 distinct years, with a maximum of 71 publications in 2005

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1994	3	17	20
1995	10	14	24
1996	3	29	32
1997	4	14	18
1998	6	15	21
1999	3	25	28
2000	6	29	35
2001	9	35	44
2002	16	51	67
2003	16	51	67
2004	10	50	60
2005	6	65	71
2006	8	44	52
2007	8	42	50
2008	8	40	48
2009	9	36	45
2010	11	40	51
2011	6	43	49
2012	7	34	41
2013	13	27	40
2014	7	32	39
2015	12	31	43
2016	11	24	35
2017	13	13	26
2018	10	21	31
2019	6	12	18
2020	9	16	25
2021	4	13	17
2022	0	18	18
2023	1	11	12
2024	4	3	7

Below are the most recent publications written about "RNA, Messenger" by people in Profiles.

Susorov D, Echeverria D, Khvorova A, Korostelev AA. mRNA-specific readthrough of nonsense codons by antisense oligonucleotides (R-ASOs). Nucleic Acids Res. 2024 Aug 27; 52(15):8687-8701.

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Allen S, O'Reilly D, Miller R, Sapp E, Summers A, Paquette J, Echeverria Moreno D, Bramato B, McHugh N, Yamada K, Aronin N, DiFiglia M, Khvorova A. mRNA Nuclear Clustering Leads to a Difference in Mutant Huntingtin mRNA and Protein Silencing by siRNAs In Vivo. Nucleic Acid Ther. 2024 08; 34(4):164-172.

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O'Reilly ME, Ho S, Coronel J, Zhu L, Liu W, Xue C, Kim E, Cynn E, Matias CV, Soni RK, Wang C, Ionita-Laza I, Bauer RC, Ross L, Zhang Y, Corvera S, Fried SK, Reilly MP. linc-ADAIN, a human adipose lincRNA, regulates adipogenesis by modulating KLF5 and IL-8 mRNA stability. Cell Rep. 2024 May 28; 43(5):114240.

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Mercier BC, Labaronne E, Cluet D, Guiguettaz L, Fontrodona N, Bicknell A, Corbin A, Wencker M, Aube F, Modolo L, Jouravleva K, Auboeuf D, Moore MJ, Ricci EP. Translation-dependent and -independent mRNA decay occur through mutually exclusive pathways defined by ribosome density during T cell activation. Genome Res. 2024 04 25; 34(3):394-409.

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Bicknell AA, Reid DW, Licata MC, Jones AK, Cheng YM, Li M, Hsiao CJ, Pepin CS, Metkar M, Levdansky Y, Fritz BR, Andrianova EA, Jain R, Valkov E, K?hrer C, Moore MJ. Attenuating ribosome load improves protein output from mRNA by limiting translation-dependent mRNA decay. Cell Rep. 2024 Apr 23; 43(4):114098.

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Ferreira HJ, Stevenson BJ, Pak H, Yu F, Almeida Oliveira J, Huber F, Taillandier-Coindard M, Michaux J, Ricart-Altimiras E, Kraemer AI, Kandalaft LE, Speiser DE, Nesvizhskii AI, M?ller M, Bassani-Sternberg M. Immunopeptidomics-based identification of naturally presented non-canonical circRNA-derived peptides. Nat Commun. 2024 Mar 15; 15(1):2357.

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Torres-Ulloa L, Calvo-Roitberg E, Pai AA. Genome-wide kinetic profiling of pre-mRNA 3' end cleavage. RNA. 2024 Feb 16; 30(3):256-270.

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Heinrich S, Hondele M, Marchand D, Derrer CP, Zedan M, Oswald A, Malinovska L, Uliana F, Khawaja S, Mancini R, Grunwald D, Weis K. Glucose stress causes mRNA retention in nuclear Nab2 condensates. Cell Rep. 2024 01 23; 43(1):113593.

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Metkar M, Pepin CS, Moore MJ. Tailor made: the art of therapeutic mRNA design. Nat Rev Drug Discov. 2024 01; 23(1):67-83.

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Plumb ID, Briggs Hagen M, Wiegand R, Dumyati G, Myers C, Harland KK, Krishnadasan A, James Gist J, Abedi G, Fleming-Dutra KE, Chea N, Lee JE, Kellogg M, Edmundson A, Britton A, Wilson LE, Lovett SA, Ocampo V, Markus TM, Smithline HA, Hou PC, Lee LC, Mower W, Rwamwejo F, Steele MT, Lim SC, Schrading WA, Chinnock B, Beiser DG, Faine B, Haran JP, Nandi U, Chipman AK, LoVecchio F, Eucker S, Femling J, Fuller M, Rothman RE, Curlin ME, Talan DA, Mohr NM. Effectiveness of a bivalent mRNA vaccine dose against symptomatic SARS-CoV-2 infection among U.S. Healthcare personnel, September 2022-May 2023. Vaccine. 2024 Apr 11; 42(10):2543-2552.

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