X Chromosome Inactivation

"X Chromosome Inactivation" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A dosage compensation process occurring at an early embryonic stage in mammalian development whereby, at random, one X CHROMOSOME of the pair is repressed in the somatic cells of females.

Descriptor ID	D049951
MeSH Number(s)	G05.308.203.249.970
Concept/Terms	X Chromosome Inactivation X Chromosome Inactivation Chromosome Inactivation, X Inactivation, X Chromosome Lyonization X-Inactivation X Inactivation Inactivation, X X Inactivations Lyon Hypothesis Lyon Hypothesis Hypothesis, Lyon

Below are MeSH descriptors whose meaning is more general than "X Chromosome Inactivation".

Biological Sciences [G]
Genetic Phenomena [G05]
Gene Expression Regulation [G05.308]
Epigenesis, Genetic [G05.308.203]
Dosage Compensation, Genetic [G05.308.203.249]
X Chromosome Inactivation [G05.308.203.249.970]

Below are MeSH descriptors whose meaning is related to "X Chromosome Inactivation".

Below are MeSH descriptors whose meaning is more specific than "X Chromosome Inactivation".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "X Chromosome Inactivation" by people in this website by year, and whether "X Chromosome Inactivation" was a major or minor topic of these publications.

Bar chart showing 28 publications over 14 distinct years, with a maximum of 5 publications in 2016

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2005	1	0	1
2006	1	1	2
2007	2	2	4
2008	1	0	1
2010	1	0	1
2011	1	0	1
2012	2	1	3
2013	0	2	2
2014	3	0	3
2015	1	0	1
2016	2	3	5
2017	1	0	1
2019	1	0	1
2020	1	1	2

Below are the most recent publications written about "X Chromosome Inactivation" by people in Profiles.

Dossin F, Pinheiro I, Zylicz JJ, Roensch J, Collombet S, Le Saux A, Chelmicki T, Attia M, Kapoor V, Zhan Y, Dingli F, Loew D, Mercher T, Dekker J, Heard E. SPEN integrates transcriptional and epigenetic control of X-inactivation. Nature. 2020 02; 578(7795):455-460.

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Czerminski JT, Lawrence JB. Silencing Trisomy 21 with XIST in Neural Stem Cells Promotes Neuronal Differentiation. Dev Cell. 2020 02 10; 52(3):294-308.e3.

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Gdula MR, Nesterova TB, Pintacuda G, Godwin J, Zhan Y, Ozadam H, McClellan M, Moralli D, Krueger F, Green CM, Reik W, Kriaucionis S, Heard E, Dekker J, Brockdorff N. The non-canonical SMC protein SmcHD1 antagonises TAD formation and compartmentalisation on the inactive X chromosome. Nat Commun. 2019 01 03; 10(1):30.

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Wang F, McCannell KN, Bo?kovic A, Zhu X, Shin J, Yu J, Gallant J, Byron M, Lawrence JB, Zhu LJ, Jones SN, Rando OJ, Fazzio TG, Bach I. Rlim-Dependent and -Independent Pathways for X Chromosome Inactivation in Female ESCs. Cell Rep. 2017 12 26; 21(13):3691-3699.

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Kolpa HJ, Fackelmayer FO, Lawrence JB. SAF-A Requirement in Anchoring XIST RNA to Chromatin Varies in Transformed and Primary Cells. Dev Cell. 2016 10 10; 39(1):9-10.

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Wang F, Shin J, Shea JM, Yu J, Bo?kovic A, Byron M, Zhu X, Shalek AK, Regev A, Lawrence JB, Torres EM, Zhu LJ, Rando OJ, Bach I. Regulation of X-linked gene expression during early mouse development by Rlim. Elife. 2016 09 19; 5.

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Chen CK, Blanco M, Jackson C, Aznauryan E, Ollikainen N, Surka C, Chow A, Cerase A, McDonel P, Guttman M. Xist recruits the X chromosome to the nuclear lamina to enable chromosome-wide silencing. Science. 2016 10 28; 354(6311):468-472.

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Giorgetti L, Lajoie BR, Carter AC, Attia M, Zhan Y, Xu J, Chen CJ, Kaplan N, Chang HY, Heard E, Dekker J. Structural organization of the inactive X chromosome in the mouse. Nature. 2016 07 28; 535(7613):575-9.

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Dekker J, Mirny L. The 3D Genome as Moderator of Chromosomal Communication. Cell. 2016 Mar 10; 164(6):1110-1121.

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Tan K, An L, Miao K, Ren L, Hou Z, Tao L, Zhang Z, Wang X, Xia W, Liu J, Wang Z, Xi G, Gao S, Sui L, Zhu DS, Wang S, Wu Z, Bach I, Chen DB, Tian J. Impaired imprinted X chromosome inactivation is responsible for the skewed sex ratio following in vitro fertilization. Proc Natl Acad Sci U S A. 2016 Mar 22; 113(12):3197-202.

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