 Apolipoprotein E4
"Apolipoprotein E4" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A major and the second most common isoform of apolipoprotein E. In humans, Apo E4 differs from APOLIPOPROTEIN E3 at only one residue 112 (cysteine is replaced by arginine), and exhibits a lower resistance to denaturation and greater propensity to form folded intermediates. Apo E4 is a risk factor for ALZHEIMER DISEASE and CARDIOVASCULAR DISEASES.
| Descriptor ID |
D053327
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| MeSH Number(s) |
D10.532.091.500.750 D12.776.070.400.500.750 D12.776.521.120.500.750
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| Concept/Terms |
Apolipoprotein E4- Apolipoprotein E4
- Apolipoprotein E-4
- Apolipoprotein E 4
- Apo E4
- ApoE4
- Apo E epsilon 4
- Apo E-4
- Apo E 4
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Below are MeSH descriptors whose meaning is more general than "Apolipoprotein E4".
Below are MeSH descriptors whose meaning is more specific than "Apolipoprotein E4".
This graph shows the total number of publications written about "Apolipoprotein E4" by people in this website by year, and whether "Apolipoprotein E4" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 0 | 1 | 1 | | 2007 | 0 | 1 | 1 | | 2009 | 2 | 0 | 2 | | 2011 | 3 | 0 | 3 | | 2012 | 0 | 1 | 1 | | 2013 | 1 | 0 | 1 | | 2014 | 1 | 0 | 1 | | 2015 | 0 | 1 | 1 | | 2016 | 1 | 0 | 1 |
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Below are the most recent publications written about "Apolipoprotein E4" by people in Profiles.
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Calderón-Garcidueñas L, Jewells V, Galaz-Montoya C, van Zundert B, Pérez-Calatayud A, Ascencio-Ferrel E, Valencia-Salazar G, Sandoval-Cano M, Carlos E, Solorio E, Acuña-Ayala H, Torres-Jardón R, D'Angiulli A. Interactive and additive influences of Gender, BMI and Apolipoprotein 4 on cognition in children chronically exposed to high concentrations of PM2.5 and ozone. APOE 4 females are at highest risk in Mexico City. Environ Res. 2016 10; 150:411-422.
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McEvoy LK, Fennema-Notestine C, Eyler LT, Franz CE, Hagler DJ, Lyons MJ, Panizzon MS, Rinker DA, Dale AM, Kremen WS. Hypertension-related alterations in white matter microstructure detectable in middle age. Hypertension. 2015 Aug; 66(2):317-23.
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Ramirez A, van der Flier WM, Herold C, Ramonet D, Heilmann S, Lewczuk P, Popp J, Lacour A, Drichel D, Louwersheimer E, Kummer MP, Cruchaga C, Hoffmann P, Teunissen C, Holstege H, Kornhuber J, Peters O, Naj AC, Chouraki V, Bellenguez C, Gerrish A. SUCLG2 identified as both a determinator of CSF Aß1-42 levels and an attenuator of cognitive decline in Alzheimer's disease. Hum Mol Genet. 2014 Dec 15; 23(24):6644-58.
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Panizzon MS, Hauger R, Xian H, Vuoksimaa E, Spoon KM, Mendoza SP, Jacobson KC, Vasilopoulos T, Rana BK, McKenzie R, McCaffery JM, Lyons MJ, Kremen WS, Franz CE. Interaction of APOE genotype and testosterone on episodic memory in middle-aged men. Neurobiol Aging. 2014 Jul; 35(7):1778.e1-8.
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Selezneva ND, Roshchina IF, Gavrilova SI, Fedorova IaB, Gantman MV, Korovaitseva GI, Kunizheva SS, Rogaev EI. [Mental disorders of cognitive and non-cognitive spectrum in the first-degree relatives of patients with Alzheimer's disease]. Zh Nevrol Psikhiatr Im S S Korsakova. 2012; 112(10):8-13.
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Ponomareva NV, Goltsov AY, Kunijeva SS, Scheglova NS, Malina DD, Mitrofanov AA, Boikova TI, Rogaev EI. Age- and genotype-related neurophysiologic reactivity to oxidative stress in healthy adults. Neurobiol Aging. 2012 Apr; 33(4):839.e11-21.
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Ready RE, Baran B, Chaudhry M, Schatz K, Gordon J, Spencer RM. Apolipoprotein E-e4, processing speed, and white matter volume in a genetically enriched sample of midlife adults. Am J Alzheimers Dis Other Demen. 2011 Sep; 26(6):463-8.
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Fennema-Notestine C, Panizzon MS, Thompson WR, Chen CH, Eyler LT, Fischl B, Franz CE, Grant MD, Jak AJ, Jernigan TL, Lyons MJ, Neale MC, Seidman LJ, Tsuang MT, Xian H, Dale AM, Kremen WS. Presence of ApoE e4 allele associated with thinner frontal cortex in middle age. J Alzheimers Dis. 2011; 26 Suppl 3:49-60.
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Braga LW, Borigato EV, Speck-Martins CE, Imamura EU, Gorges AM, Izumi AP, Dantas RC, Nunes LG. Apolipoprotein E genotype and cerebral palsy. Dev Med Child Neurol. 2010 Jul; 52(7):666-71.
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Chopra MP, Landes RD, Jones RA, Feldman ZL, Beck C, Griffin ST. Does the apolipoprotein E epsilon 4 genotype influence the expression of depression with cognitive impairment? Int J Geriatr Psychiatry. 2009 Jun; 24(6):650-2.
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