Glycogen Synthase Kinase 3

"Glycogen Synthase Kinase 3" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A glycogen synthase kinase that was originally described as a key enzyme involved in glycogen metabolism. It regulates a diverse array of functions such as CELL DIVISION, microtubule function and APOPTOSIS.

Descriptor ID	D038362
MeSH Number(s)	D05.500.117.875 D08.811.913.696.620.682.700.429.500 D08.811.913.696.620.682.700.646.625 D12.644.360.300.500 D12.776.476.081.875 D12.776.476.300.500
Concept/Terms	Glycogen Synthase Kinase 3 Glycogen Synthase Kinase 3 gsk-3 Gene Product GSK-3

Below are MeSH descriptors whose meaning is more general than "Glycogen Synthase Kinase 3".

Chemicals and Drugs [D]
Macromolecular Substances [D05]
Multiprotein Complexes [D05.500]
Axin Signaling Complex [D05.500.117]
Glycogen Synthase Kinase 3 [D05.500.117.875]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Transferases [D08.811.913]
Phosphotransferases [D08.811.913.696]
Phosphotransferases (Alcohol Group Acceptor) [D08.811.913.696.620]
Protein Kinases [D08.811.913.696.620.682]
Protein-Serine-Threonine Kinases [D08.811.913.696.620.682.700]
Glycogen Synthase Kinases [D08.811.913.696.620.682.700.429]
Glycogen Synthase Kinase 3 [D08.811.913.696.620.682.700.429.500]
Proline-Directed Protein Kinases [D08.811.913.696.620.682.700.646]
Glycogen Synthase Kinase 3 [D08.811.913.696.620.682.700.646.625]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intracellular Signaling Peptides and Proteins [D12.644.360]
Glycogen Synthase Kinases [D12.644.360.300]
Glycogen Synthase Kinase 3 [D12.644.360.300.500]
Proteins [D12.776]
Intracellular Signaling Peptides and Proteins [D12.776.476]
Axin Signaling Complex [D12.776.476.081]
Glycogen Synthase Kinase 3 [D12.776.476.081.875]
Glycogen Synthase Kinases [D12.776.476.300]
Glycogen Synthase Kinase 3 [D12.776.476.300.500]

Below are MeSH descriptors whose meaning is related to "Glycogen Synthase Kinase 3".

Below are MeSH descriptors whose meaning is more specific than "Glycogen Synthase Kinase 3".

Glycogen Synthase Kinase 3
Glycogen Synthase Kinase 3 beta

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Glycogen Synthase Kinase 3" by people in this website by year, and whether "Glycogen Synthase Kinase 3" was a major or minor topic of these publications.

Bar chart showing 30 publications over 16 distinct years, with a maximum of 5 publications in 2005

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1999	0	2	2
2001	0	1	1
2002	0	1	1
2004	1	0	1
2005	1	4	5
2006	0	2	2
2007	1	0	1
2008	3	0	3
2009	0	1	1
2010	1	1	2
2013	0	2	2
2014	2	1	3
2015	2	1	3
2016	0	1	1
2017	0	1	1
2019	0	1	1

Below are the most recent publications written about "Glycogen Synthase Kinase 3" by people in Profiles.

Chen L, Zhou L, Yu P, Fang F, Jiang L, Fei J, Xiao H, Wang J. Methamphetamine exposure upregulates the amyloid precursor protein and hyperphosphorylated tau expression: The roles of insulin signaling in SH-SY5Y cell line. J Toxicol Sci. 2019; 44(7):493-503.

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Wang T, Xie C, Yu P, Fang F, Zhu J, Cheng J, Gu A, Wang J, Xiao H. Involvement of Insulin Signaling Disturbances in Bisphenol A-Induced Alzheimer's Disease-like Neurotoxicity. Sci Rep. 2017 08 08; 7(1):7497.

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Orme MH, Liccardi G, Moderau N, Feltham R, Wicky-John S, Tenev T, Aram L, Wilson R, Bianchi K, Morris O, Monteiro Domingues C, Robertson D, Tare M, Wepf A, Williams D, Bergmann A, Gstaiger M, Arama E, Ribeiro PS, Meier P. The unconventional myosin CRINKLED and its mammalian orthologue MYO7A regulate caspases in their signalling roles. Nat Commun. 2016 Mar 10; 7:10972.

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Jurczyk A, Nowosielska A, Przewozniak N, Aryee KE, DiIorio P, Blodgett D, Yang C, Campbell-Thompson M, Atkinson M, Shultz L, Rittenhouse A, Harlan D, Greiner D, Bortell R. Beyond the brain: disrupted in schizophrenia 1 regulates pancreatic ?-cell function via glycogen synthase kinase-3?. FASEB J. 2016 Feb; 30(2):983-93.

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Arnold AC, Robertson D. Defective Wnt Signaling: A Potential Contributor to Cardiometabolic Disease? Diabetes. 2015 Oct; 64(10):3342-4.

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Fang F, Chen D, Yu P, Qian W, Zhou J, Liu J, Gao R, Wang J, Xiao H. Effects of Bisphenol A on glucose homeostasis and brain insulin signaling pathways in male mice. Gen Comp Endocrinol. 2015 Feb 01; 212:44-50.

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Jones CI, Sage T, Moraes LA, Vaiyapuri S, Hussain U, Tucker KL, Barrett NE, Gibbins JM. Platelet endothelial cell adhesion molecule-1 inhibits platelet response to thrombin and von Willebrand factor by regulating the internalization of glycoprotein Ib via AKT/glycogen synthase kinase-3/dynamin and integrin ?IIb?3. Arterioscler Thromb Vasc Biol. 2014 Sep; 34(9):1968-76.

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Landis J, Shaw LM. Insulin receptor substrate 2-mediated phosphatidylinositol 3-kinase signaling selectively inhibits glycogen synthase kinase 3? to regulate aerobic glycolysis. J Biol Chem. 2014 Jun 27; 289(26):18603-13.

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Zhang W, Xiao H, Parkin KL. Apoptosis in MCF-7 breast cancer cells induced by S-alkenylmercaptocysteine (CySSR) species derived from Allium tissues in combination with sodium selenite. Food Chem Toxicol. 2014 Jun; 68:1-10.

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Guendel I, Iordanskiy S, Van Duyne R, Kehn-Hall K, Saifuddin M, Das R, Jaworski E, Sampey GC, Senina S, Shultz L, Narayanan A, Chen H, Lepene B, Zeng C, Kashanchi F. Novel neuroprotective GSK-3? inhibitor restricts Tat-mediated HIV-1 replication. J Virol. 2014 Jan; 88(2):1189-208.

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