Core Binding Factor Alpha 2 Subunit

"Core Binding Factor Alpha 2 Subunit" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A transcription factor that dimerizes with the cofactor CORE BINDING FACTOR BETA SUBUNIT to form core binding factor. It contains a highly conserved DNA-binding domain known as the runt domain. Runx1 is frequently mutated in human LEUKEMIAS.

Descriptor ID	D050676
MeSH Number(s)	D12.776.930.155.200.200
Concept/Terms	Core Binding Factor Alpha 2 Subunit Core Binding Factor Alpha 2 Subunit Runx1 Protein Pebp2a2 Protein Runt-Related Transcription Factor 1 Runt Related Transcription Factor 1 Acute Myeloid Leukemia 1 Protein Core-Binding Factor Alpha 2 Protein Core Binding Factor Alpha 2 Protein Acute Myeloid Leukemia 1D Protein Acute Myeloid Leukemia 1D Protein AML1D Protein Acute Myeloid Leukemia 1C Protein Acute Myeloid Leukemia 1C Protein AML1C Protein Acute Myeloid Leukemia 1B Protein Acute Myeloid Leukemia 1B Protein AML1B Protein Acute Myeloid Leukemia 1A Protein Acute Myeloid Leukemia 1A Protein AML1A Protein

Below are MeSH descriptors whose meaning is more general than "Core Binding Factor Alpha 2 Subunit".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Transcription Factors [D12.776.930]
Core Binding Factors [D12.776.930.155]
Core Binding Factor alpha Subunits [D12.776.930.155.200]
Core Binding Factor Alpha 2 Subunit [D12.776.930.155.200.200]

Below are MeSH descriptors whose meaning is related to "Core Binding Factor Alpha 2 Subunit".

Below are MeSH descriptors whose meaning is more specific than "Core Binding Factor Alpha 2 Subunit".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Core Binding Factor Alpha 2 Subunit" by people in this website by year, and whether "Core Binding Factor Alpha 2 Subunit" was a major or minor topic of these publications.

Bar chart showing 57 publications over 21 distinct years, with a maximum of 5 publications in 2005 and 2015 and 2017 and 2023

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2000	0	1	1
2002	0	2	2
2003	0	1	1
2004	0	3	3
2005	1	4	5
2006	1	0	1
2008	1	0	1
2009	4	0	4
2010	2	1	3
2012	3	1	4
2013	2	0	2
2014	0	1	1
2015	3	2	5
2016	4	0	4
2017	5	0	5
2018	2	2	4
2020	2	0	2
2021	1	0	1
2023	2	3	5
2024	0	2	2
2025	1	0	1

Below are the most recent publications written about "Core Binding Factor Alpha 2 Subunit" by people in Profiles.

Mohammadhosseini M, Enright T, Duvall A, Chitsazan A, Lin HY, Ors A, Davis BA, Nikolova O, Bresciani E, Diemer J, Craft K, Menezes AC, Merguerian M, Chong S, Calvo KR, Deuitch NT, Glushakow-Smith S, Gritsman K, Godley LA, Horwitz MS, Keel S, Castilla LH, Demir E, Mohammed H, Liu P, Agarwal A. Targeting the CD74 signaling axis suppresses inflammation and rescues defective hematopoiesis in RUNX1-familial platelet disorder. Sci Transl Med. 2025 Jan 08; 17(780):eadn9832.

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Kim H, Tan TK, Lee DZY, Huang XZ, Ong JZL, Kelliher MA, Yeoh AEJ, Sanda T, Tan SH. Oncogenic dependency on SWI/SNF chromatin remodeling factors in T-cell acute lymphoblastic leukemia. Leukemia. 2024 Sep; 38(9):1906-1917.

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Patel SA, Gerber WK, Zheng R, Khanna S, Hutchinson L, Abel GA, Cerny J, DaSilva BA, Zhang TY, Ramanathan M, Khedr S, Selove W, Woda B, Miron PM, Higgins AW, Gerber JM. Natural history of clonal haematopoiesis seen in real-world haematology settings. Br J Haematol. 2024 May; 204(5):1844-1855.

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Ahmad MH, Hegde M, Wong WJ, Mohammadhosseini M, Garrett L, Carrascoso A, Issac N, Ebert B, Silva JC, Pihan G, Zhu LJ, Wolfe SA, Agarwal A, Liu PP, Castilla LH. Runx1-R188Q germ line mutation induces inflammation and predisposition to hematologic malignancies in mice. Blood Adv. 2023 12 12; 7(23):7304-7318.

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Martin V, Zhuang F, Zhang Y, Pinheiro K, Gord?n R. High-throughput data and modeling reveal insights into the mechanisms of cooperative DNA-binding by transcription factor proteins. Nucleic Acids Res. 2023 Nov 27; 51(21):11600-11612.

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Konkimalla A, Konishi S, Macadlo L, Kobayashi Y, Farino ZJ, Miyashita N, El Haddad L, Morowitz J, Barkauskas CE, Agarwal P, Souma T, ElMallah MK, Tata A, Tata PR. Transitional cell states sculpt tissue topology during lung regeneration. Cell Stem Cell. 2023 11 02; 30(11):1486-1502.e9.

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Zezulin AU, Yen D, Ye D, Howell ED, Bresciani E, Diemer J, Ren JG, Ahmad MH, Castilla LH, Touw IP, Minn AJ, Tong W, Liu PP, Tan K, Yu W, Speck NA. RUNX1 is required in granulocyte-monocyte progenitors to attenuate inflammatory cytokine production by neutrophils. Genes Dev. 2023 07 01; 37(13-14):605-620.

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Che X, Jin X, Park NR, Kim HJ, Kyung HS, Kim HJ, Lian JB, Stein JL, Stein GS, Choi JY. Cbf? Is a Novel Modulator against Osteoarthritis by Maintaining Articular Cartilage Homeostasis through TGF-? Signaling. Cells. 2023 03 31; 12(7).

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Mill CP, Fiskus W, DiNardo CD, Birdwell C, Davis JA, Kadia TM, Takahashi K, Short N, Daver N, Ohanian M, Borthakur G, Kornblau SM, Green MR, Qi Y, Su X, Khoury JD, Bhalla KN. Effective therapy for AML with RUNX1 mutation by cotreatment with inhibitors of protein translation and BCL2. Blood. 2022 02 10; 139(6):907-921.

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van der Kouwe E, Heller G, Czibere A, Pulikkan JA, Agreiter C, Castilla LH, Delwel R, Di Ruscio A, Ebralidze AK, Forte M, Grebien F, Heyes E, Kazianka L, Klinger J, Kornauth C, Le T, Lind K, Barbosa IAM, Pemovska T, Pichler A, Schmolke AS, Schweicker CM, Sill H, Sperr WR, Spittler A, Surapally S, Trinh BQ, Valent P, Vanura K, Welner RS, Zuber J, Tenen DG, Staber PB. Core-binding factor leukemia hijacks the T-cell-prone PU.1 antisense promoter. Blood. 2021 10 14; 138(15):1345-1358.

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