Core Binding Factor Alpha 2 Subunit

"Core Binding Factor Alpha 2 Subunit" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A transcription factor that dimerizes with the cofactor CORE BINDING FACTOR BETA SUBUNIT to form core binding factor. It contains a highly conserved DNA-binding domain known as the runt domain. Runx1 is frequently mutated in human LEUKEMIAS.

Descriptor ID	D050676
MeSH Number(s)	D12.776.930.155.200.200
Concept/Terms	Core Binding Factor Alpha 2 Subunit Core Binding Factor Alpha 2 Subunit Runx1 Protein Pebp2a2 Protein Runt-Related Transcription Factor 1 Runt Related Transcription Factor 1 Acute Myeloid Leukemia 1 Protein Core-Binding Factor Alpha 2 Protein Core Binding Factor Alpha 2 Protein Acute Myeloid Leukemia 1D Protein Acute Myeloid Leukemia 1D Protein AML1D Protein Acute Myeloid Leukemia 1C Protein Acute Myeloid Leukemia 1C Protein AML1C Protein Acute Myeloid Leukemia 1B Protein Acute Myeloid Leukemia 1B Protein AML1B Protein Acute Myeloid Leukemia 1A Protein Acute Myeloid Leukemia 1A Protein AML1A Protein

Below are MeSH descriptors whose meaning is more general than "Core Binding Factor Alpha 2 Subunit".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Transcription Factors [D12.776.930]
Core Binding Factors [D12.776.930.155]
Core Binding Factor alpha Subunits [D12.776.930.155.200]
Core Binding Factor Alpha 2 Subunit [D12.776.930.155.200.200]

Below are MeSH descriptors whose meaning is related to "Core Binding Factor Alpha 2 Subunit".

Below are MeSH descriptors whose meaning is more specific than "Core Binding Factor Alpha 2 Subunit".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Core Binding Factor Alpha 2 Subunit" by people in this website by year, and whether "Core Binding Factor Alpha 2 Subunit" was a major or minor topic of these publications.

Bar chart showing 49 publications over 18 distinct years, with a maximum of 5 publications in 2005 and 2015 and 2017

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2000	0	1	1
2003	0	1	1
2004	0	3	3
2005	1	4	5
2006	1	0	1
2008	1	0	1
2009	4	0	4
2010	2	1	3
2012	3	1	4
2013	2	0	2
2014	0	1	1
2015	3	2	5
2016	4	0	4
2017	5	0	5
2018	2	2	4
2020	2	0	2
2021	1	1	2
2023	0	1	1

Below are the most recent publications written about "Core Binding Factor Alpha 2 Subunit" by people in Profiles.

Che X, Jin X, Park NR, Kim HJ, Kyung HS, Kim HJ, Lian JB, Stein JL, Stein GS, Choi JY. Cbf? Is a Novel Modulator against Osteoarthritis by Maintaining Articular Cartilage Homeostasis through TGF-? Signaling. Cells. 2023 03 31; 12(7).

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Mill CP, Fiskus W, DiNardo CD, Birdwell C, Davis JA, Kadia TM, Takahashi K, Short N, Daver N, Ohanian M, Borthakur G, Kornblau SM, Green MR, Qi Y, Su X, Khoury JD, Bhalla KN. Effective therapy for AML with RUNX1 mutation by cotreatment with inhibitors of protein translation and BCL2. Blood. 2022 02 10; 139(6):907-921.

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van der Kouwe E, Heller G, Czibere A, Pulikkan JA, Agreiter C, Castilla LH, Delwel R, Di Ruscio A, Ebralidze AK, Forte M, Grebien F, Heyes E, Kazianka L, Klinger J, Kornauth C, Le T, Lind K, Barbosa IAM, Pemovska T, Pichler A, Schmolke AS, Schweicker CM, Sill H, Sperr WR, Spittler A, Surapally S, Trinh BQ, Valent P, Vanura K, Welner RS, Zuber J, Tenen DG, Staber PB. Core-binding factor leukemia hijacks the T-cell-prone PU.1 antisense promoter. Blood. 2021 10 14; 138(15):1345-1358.

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Pauli C, Kienh?fer M, G?llner S, M?ller-Tidow C. Epitranscriptomic modifications in acute myeloid leukemia: m6A and 2'-O-methylation as targets for novel therapeutic strategies. Biol Chem. 2021 11 25; 402(12):1531-1546.

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Fritz AJ, Hong D, Boyd J, Kost J, Finstaad KH, Fitzgerald MP, Hanna S, Abuarqoub AH, Malik M, Bushweller J, Tye C, Ghule P, Gordon J, Frietze S, Zaidi SK, Lian JB, Stein JL, Stein GS. RUNX1 and RUNX2 transcription factors function in opposing roles to regulate breast cancer stem cells. J Cell Physiol. 2020 10; 235(10):7261-7272.

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Farina NH, Scalia S, Adams CE, Hong D, Fritz AJ, Messier TL, Balatti V, Veneziano D, Lian JB, Croce CM, Stein GS, Stein JL. Identification of tRNA-derived small RNA (tsRNA) responsive to the tumor suppressor, RUNX1, in breast cancer. J Cell Physiol. 2020 06; 235(6):5318-5327.

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Mill CP, Fiskus W, DiNardo CD, Qian Y, Raina K, Rajapakshe K, Perera D, Coarfa C, Kadia TM, Khoury JD, Saenz DT, Saenz DN, Illendula A, Takahashi K, Kornblau SM, Green MR, Futreal AP, Bushweller JH, Crews CM, Bhalla KN. RUNX1-targeted therapy for AML expressing somatic or germline mutation in RUNX1. Blood. 2019 07 04; 134(1):59-73.

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Hong D, Fritz AJ, Gordon JA, Tye CE, Boyd JR, Tracy KM, Frietze SE, Carr FE, Nickerson JA, Van Wijnen AJ, Imbalzano AN, Zaidi SK, Lian JB, Stein JL, Stein GS. RUNX1-dependent mechanisms in biological control and dysregulation in cancer. J Cell Physiol. 2019 06; 234(6):8597-8609.

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Hong D, Fritz AJ, Finstad KH, Fitzgerald MP, Weinheimer A, Viens AL, Ramsey J, Stein JL, Lian JB, Stein GS. Suppression of Breast Cancer Stem Cells and Tumor Growth by the RUNX1 Transcription Factor. Mol Cancer Res. 2018 12; 16(12):1952-1964.

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Pulikkan JA, Hegde M, Ahmad HM, Belaghzal H, Illendula A, Yu J, O'Hagan K, Ou J, Muller-Tidow C, Wolfe SA, Zhu LJ, Dekker J, Bushweller JH, Castilla LH. CBF?-SMMHC Inhibition Triggers Apoptosis by Disrupting MYC Chromatin Dynamics in Acute Myeloid Leukemia. Cell. 2018 06 28; 174(1):172-186.e21.

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