Core Binding Factor Alpha 3 Subunit

"Core Binding Factor Alpha 3 Subunit" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A transcription factor that dimerizes with the cofactor CORE BINDING FACTOR BETA SUBUNIT to form core binding factor. It contains a highly conserved DNA-binding domain known as the runt domain.

Descriptor ID	D050677
MeSH Number(s)	D12.776.930.155.200.300
Concept/Terms	Core Binding Factor Alpha 3 Subunit Core Binding Factor Alpha 3 Subunit AML2 Protein CBFA3 Protein Runx3 Protein PEBP2A3 Protein Runt Domain Transcription Factor AML-2 Runt-Related Transcription Factor 3 Protein Runt Related Transcription Factor 3 Protein Acute Myeloid Leukemia 2 Protein Core-Binding Factor Alpha 3 Protein Core Binding Factor Alpha 3 Protein

Below are MeSH descriptors whose meaning is more general than "Core Binding Factor Alpha 3 Subunit".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Transcription Factors [D12.776.930]
Core Binding Factors [D12.776.930.155]
Core Binding Factor alpha Subunits [D12.776.930.155.200]
Core Binding Factor Alpha 3 Subunit [D12.776.930.155.200.300]

Below are MeSH descriptors whose meaning is related to "Core Binding Factor Alpha 3 Subunit".

Below are MeSH descriptors whose meaning is more specific than "Core Binding Factor Alpha 3 Subunit".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Core Binding Factor Alpha 3 Subunit" by people in this website by year, and whether "Core Binding Factor Alpha 3 Subunit" was a major or minor topic of these publications.

Bar chart showing 4 publications over 3 distinct years, with a maximum of 2 publications in 2004

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2003	0	1	1
2004	0	2	2
2009	1	0	1

Below are the most recent publications written about "Core Binding Factor Alpha 3 Subunit" by people in Profiles.

Wigner NA, Soung do Y, Einhorn TA, Drissi H, Gerstenfeld LC. Functional role of Runx3 in the regulation of aggrecan expression during cartilage development. J Cell Physiol. 2013 Nov; 228(11):2232-42.

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Min B, Kim MK, Zhang JW, Kim J, Chung KC, Oh BC, Stein GS, Lee YH, van Wijnen AJ, Bae SC. Identification of RUNX3 as a component of the MST/Hpo signaling pathway. J Cell Physiol. 2012 Feb; 227(2):839-49.

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Yagi R, Junttila IS, Wei G, Urban JF, Zhao K, Paul WE, Zhu J. The transcription factor GATA3 actively represses RUNX3 protein-regulated production of interferon-gamma. Immunity. 2010 Apr 23; 32(4):507-17.

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Chi XZ, Kim J, Lee YH, Lee JW, Lee KS, Wee H, Kim WJ, Park WY, Oh BC, Stein GS, Ito Y, van Wijnen AJ, Bae SC. Runt-related transcription factor RUNX3 is a target of MDM2-mediated ubiquitination. Cancer Res. 2009 Oct 15; 69(20):8111-9.

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Pande S, Ali SA, Dowdy C, Zaidi SK, Ito K, Ito Y, Montecino MA, Lian JB, Stein JL, van Wijnen AJ, Stein GS. Subnuclear targeting of the Runx3 tumor suppressor and its epigenetic association with mitotic chromosomes. J Cell Physiol. 2009 Mar; 218(3):473-9.

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Soung do Y, Dong Y, Wang Y, Zuscik MJ, Schwarz EM, O'Keefe RJ, Drissi H. Runx3/AML2/Cbfa3 regulates early and late chondrocyte differentiation. J Bone Miner Res. 2007 Aug; 22(8):1260-70.

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van Wijnen AJ, Stein GS, Gergen JP, Groner Y, Hiebert SW, Ito Y, Liu P, Neil JC, Ohki M, Speck N. Nomenclature for Runt-related (RUNX) proteins. Oncogene. 2004 May 24; 23(24):4209-10.

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Stein GS, Lian JB, van Wijnen AJ, Stein JL, Montecino M, Javed A, Zaidi SK, Young DW, Choi JY, Pockwinse SM. Runx2 control of organization, assembly and activity of the regulatory machinery for skeletal gene expression. Oncogene. 2004 May 24; 23(24):4315-29.

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Lian JB, Javed A, Zaidi SK, Lengner C, Montecino M, van Wijnen AJ, Stein JL, Stein GS. Regulatory controls for osteoblast growth and differentiation: role of Runx/Cbfa/AML factors. Crit Rev Eukaryot Gene Expr. 2004; 14(1-2):1-41.

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Stein GS, Stein JL, Lian JB, Van Wijnen AJ, Montecino M, Javed A, Zaidi SK, Young D, Choi JY, Pockwinse S. Nuclear microenvironments: an architectural platform for the convergence and integration of transcriptional regulatory signals. Eur J Histochem. 2004; 48(1):65-76.

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