"Kainic Acid" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
(2S-(2 alpha,3 beta,4 beta))-2-Carboxy-4-(1-methylethenyl)-3-pyrrolidineacetic acid. Ascaricide obtained from the red alga Digenea simplex. It is a potent excitatory amino acid agonist at some types of excitatory amino acid receptors and has been used to discriminate among receptor types. Like many excitatory amino acid agonists it can cause neurotoxicity and has been used experimentally for that purpose.
| Descriptor ID |
D007608
|
| MeSH Number(s) |
D03.383.773.400
|
| Concept/Terms |
Kainic Acid- Kainic Acid
- Acid, Kainic
- Digenic Acid
- Acid, Digenic
|
Below are MeSH descriptors whose meaning is more general than "Kainic Acid".
Below are MeSH descriptors whose meaning is more specific than "Kainic Acid".
This graph shows the total number of publications written about "Kainic Acid" by people in this website by year, and whether "Kainic Acid" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 1 | 0 | 1 |
| 1999 | 1 | 0 | 1 |
| 2000 | 1 | 0 | 1 |
| 2002 | 0 | 1 | 1 |
| 2016 | 0 | 1 | 1 |
| 2022 | 0 | 1 | 1 |
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Below are the most recent publications written about "Kainic Acid" by people in Profiles.
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Henning L, Antony H, Breuer A, M?ller J, Seifert G, Audinat E, Singh P, Brosseron F, Heneka MT, Steinh?user C, Bedner P. Reactive microglia are the major source of tumor necrosis factor alpha and contribute to astrocyte dysfunction and acute seizures in experimental temporal lobe epilepsy. Glia. 2023 02; 71(2):168-186.
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Gritsch S, Bali KK, Kuner R, Vardeh D. Functional characterization of a mouse model for central post-stroke pain. Mol Pain. 2016; 12.
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John CS, Smith KL, Van't Veer A, Gompf HS, Carlezon WA, Cohen BM, ?ng?r D, Bechtholt-Gompf AJ. Blockade of astrocytic glutamate uptake in the prefrontal cortex induces anhedonia. Neuropsychopharmacology. 2012 Oct; 37(11):2467-75.
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Somera-Molina KC, Robin B, Somera CA, Anderson C, Stine C, Koh S, Behanna HA, Van Eldik LJ, Watterson DM, Wainwright MS. Glial activation links early-life seizures and long-term neurologic dysfunction: evidence using a small molecule inhibitor of proinflammatory cytokine upregulation. Epilepsia. 2007 Sep; 48(9):1785-1800.
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Koh S, Magid R, Chung H, Stine CD, Wilson DN. Depressive behavior and selective down-regulation of serotonin receptor expression after early-life seizures: reversal by environmental enrichment. Epilepsy Behav. 2007 Feb; 10(1):26-31.
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Leski ML, Hassinger LC, Valentine SL, Baer JD, Coyle JT. L-type calcium channels reduce ROS generation in cerebellar granule cells following kainate exposure. Synapse. 2002 Jan; 43(1):30-41.
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Leski ML, Valentine SL, Baer JD, Coyle JT. Insulin-like growth factor I prevents the development of sensitivity to kainate neurotoxicity in cerebellar granule cells. J Neurochem. 2000 Oct; 75(4):1548-56.
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Tian D, Litvak V, Lev S. Cerebral ischemia and seizures induce tyrosine phosphorylation of PYK2 in neurons and microglial cells. J Neurosci. 2000 Sep 01; 20(17):6478-87.
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Leski ML, Valentine SL, Coyle JT. L-type voltage-gated calcium channels modulate kainic acid neurotoxicity in cerebellar granule cells. Brain Res. 1999 May 15; 828(1-2):27-40.
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Weiss S, Cataltepe O, Cole AJ. Anatomical studies of DNA fragmentation in rat brain after systemic kainate administration. Neuroscience. 1996 Sep; 74(2):541-51.