 Cell Aging
"Cell Aging" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The decrease in the cell's ability to proliferate with the passing of time. Each cell is programmed for a certain number of cell divisions and at the end of that time proliferation halts. The cell enters a quiescent state after which it experiences CELL DEATH via the process of APOPTOSIS.
| Descriptor ID |
D016922
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| MeSH Number(s) |
G04.299.119
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| Concept/Terms |
Cell Aging- Cell Aging
- Cell Senescence
- Senescence, Cell
- Senescence, Replicative
- Cellular Aging
- Aging, Cellular
- Replicative Senescence
- Aging, Cell
- Senescence, Cellular
- Cellular Senescence
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Below are MeSH descriptors whose meaning is more general than "Cell Aging".
Below are MeSH descriptors whose meaning is more specific than "Cell Aging".
This graph shows the total number of publications written about "Cell Aging" by people in this website by year, and whether "Cell Aging" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 0 | 1 | 1 | | 1998 | 0 | 1 | 1 | | 1999 | 0 | 1 | 1 | | 2000 | 0 | 1 | 1 | | 2001 | 0 | 1 | 1 | | 2002 | 2 | 1 | 3 | | 2003 | 0 | 1 | 1 | | 2004 | 3 | 3 | 6 | | 2005 | 2 | 0 | 2 | | 2006 | 1 | 0 | 1 | | 2007 | 3 | 4 | 7 | | 2008 | 6 | 1 | 7 | | 2009 | 3 | 2 | 5 | | 2010 | 4 | 1 | 5 | | 2011 | 4 | 3 | 7 | | 2012 | 1 | 2 | 3 | | 2013 | 3 | 5 | 8 | | 2014 | 2 | 2 | 4 | | 2015 | 2 | 0 | 2 | | 2016 | 0 | 1 | 1 |
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Below are the most recent publications written about "Cell Aging" by people in Profiles.
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Lin YF, Haynes CM. Metabolism and the UPR(mt). Mol Cell. 2016 Mar 3; 61(5):677-82.
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Vendetti FP, Lau A, Schamus S, Conrads TP, O'Connor MJ, Bakkenist CJ. The orally active and bioavailable ATR kinase inhibitor AZD6738 potentiates the anti-tumor effects of cisplatin to resolve ATM-deficient non-small cell lung cancer in vivo. Oncotarget. 2015 Dec 29; 6(42):44289-305.
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Swanson EC, Rapkin LM, Bazett-Jones DP, Lawrence JB. Unfolding the story of chromatin organization in senescent cells. Nucleus. 2015; 6(4):254-60.
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Mohrin M, Shin J, Liu Y, Brown K, Luo H, Xi Y, Haynes CM, Chen D. Stem cell aging. A mitochondrial UPR-mediated metabolic checkpoint regulates hematopoietic stem cell aging. Science. 2015 Mar 20; 347(6228):1374-7.
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Ivshina M, Lasko P, Richter JD. Cytoplasmic polyadenylation element binding proteins in development, health, and disease. Annu Rev Cell Dev Biol. 2014; 30:393-415.
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Rao RP, Scheffer L, Srideshikan SM, Parthibane V, Kosakowska-Cholody T, Masood MA, Nagashima K, Gudla P, Lockett S, Acharya U, Acharya JK. Ceramide transfer protein deficiency compromises organelle function and leads to senescence in primary cells. PLoS One. 2014; 9(3):e92142.
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Ramkumar C, Kong Y, Trabucco SE, Gerstein RM, Zhang H. Smurf2 regulates hematopoietic stem cell self-renewal and aging. Aging Cell. 2014 Jun; 13(3):478-86.
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Tie G, Messina KE, Yan J, Messina JA, Messina LM. Hypercholesterolemia induces oxidant stress that accelerates the ageing of hematopoietic stem cells. J Am Heart Assoc. 2014 Jan 27; 3(1):e000241.
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Banday AR, Baumgartner M, Al Seesi S, Karunakaran DK, Venkatesh A, Congdon S, Lemoine C, Kilcollins AM, Mandoiu I, Punzo C, Kanadia RN. Replication-dependent histone genes are actively transcribed in differentiating and aging retinal neurons. Cell Cycle. 2014; 13(16):2526-41.
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Swanson EC, Manning B, Zhang H, Lawrence JB. Higher-order unfolding of satellite heterochromatin is a consistent and early event in cell senescence. J Cell Biol. 2013 Dec 23; 203(6):929-42.
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