Core Binding Factor Alpha 1 Subunit

"Core Binding Factor Alpha 1 Subunit" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A transcription factor that dimerizes with CORE BINDING FACTOR BETA SUBUNIT to form core binding factor. It contains a highly conserved DNA-binding domain known as the runt domain and is involved in genetic regulation of skeletal development and CELL DIFFERENTIATION.

Descriptor ID	D050659
MeSH Number(s)	D12.776.930.155.200.100
Concept/Terms	Core Binding Factor Alpha 1 Subunit Core Binding Factor Alpha 1 Subunit AML3 Transcription Factor CBFA-1 Protein CBFA 1 Protein CBFA1 Protein CBFalpha Runt Domain Transcription Factor 1 Osf2 Transcription Factor PEBP2alphaA Protein Runx2 Protein SEF1 Protein SL3-3 Enhancer Factor 1 SL3 3 Enhancer Factor 1 Acute Myeloid Leukemia 3 Protein CBFalpha1 Protein

Below are MeSH descriptors whose meaning is more general than "Core Binding Factor Alpha 1 Subunit".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Transcription Factors [D12.776.930]
Core Binding Factors [D12.776.930.155]
Core Binding Factor alpha Subunits [D12.776.930.155.200]
Core Binding Factor Alpha 1 Subunit [D12.776.930.155.200.100]

Below are MeSH descriptors whose meaning is related to "Core Binding Factor Alpha 1 Subunit".

Below are MeSH descriptors whose meaning is more specific than "Core Binding Factor Alpha 1 Subunit".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Core Binding Factor Alpha 1 Subunit" by people in this website by year, and whether "Core Binding Factor Alpha 1 Subunit" was a major or minor topic of these publications.

Bar chart showing 118 publications over 22 distinct years, with a maximum of 10 publications in 2008

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2001	0	2	2
2002	0	6	6
2003	0	6	6
2004	0	9	9
2005	2	7	9
2006	4	4	8
2007	7	1	8
2008	8	2	10
2009	6	1	7
2010	6	3	9
2011	6	1	7
2012	3	0	3
2013	6	1	7
2014	5	2	7
2015	4	1	5
2016	4	1	5
2017	2	0	2
2018	2	0	2
2019	1	0	1
2020	3	0	3
2021	0	1	1
2024	1	0	1

Below are the most recent publications written about "Core Binding Factor Alpha 1 Subunit" by people in Profiles.

Toner J, Gordon JAR, Greenyer H, Kaufman P, Stein JL, Stein GS, Lian JB. RUNX2 as a Prognostic Factor in Human Cancers. Crit Rev Eukaryot Gene Expr. 2024; 34(7):51-66.

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Che X, Park NR, Jin X, Jung YK, Han MS, Park CY, Chun JS, Kim SG, Jin J, Kim HJ, Lian JB, Stein JL, Stein GS, Choi JY. Hypoxia-inducible factor 2a is a novel inhibitor of chondrocyte maturation. J Cell Physiol. 2021 10; 236(10):6963-6973.

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Aguilar R, Bustos FJ, Nardocci G, van Zundert B, Montecino M. Epigenetic silencing of the osteoblast-lineage gene program during hippocampal maturation. J Cell Biochem. 2021 04; 122(3-4):367-384.

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Kim JM, Yang YS, Park KH, Ge X, Xu R, Li N, Song M, Chun H, Bok S, Charles JF, Filhol-Cochet O, Boldyreff B, Dinter T, Yu PB, Kon N, Gu W, Takarada T, Greenblatt MB, Shim JH. A RUNX2 stabilization pathway mediates physiologic and pathologic bone formation. Nat Commun. 2020 05 08; 11(1):2289.

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Fritz AJ, Hong D, Boyd J, Kost J, Finstaad KH, Fitzgerald MP, Hanna S, Abuarqoub AH, Malik M, Bushweller J, Tye C, Ghule P, Gordon J, Frietze S, Zaidi SK, Lian JB, Stein JL, Stein GS. RUNX1 and RUNX2 transcription factors function in opposing roles to regulate breast cancer stem cells. J Cell Physiol. 2020 10; 235(10):7261-7272.

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Bolf EL, Gillis NE, Barnum MS, Beaudet CM, Yu GY, Tomczak JA, Stein JL, Lian JB, Stein GS, Carr FE. The Thyroid Hormone Receptor-RUNX2 Axis: A Novel Tumor Suppressive Pathway in Breast Cancer. Horm Cancer. 2020 02; 11(1):34-41.

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Villanueva F, Araya H, Brice?o P, Varela N, Stevenson A, Jerez S, Tempio F, Chnaiderman J, Perez C, Villarroel M, Concha E, Khani F, Thaler R, Salazar-Onfray F, Stein GS, van Wijnen AJ, Galindo M. The cancer-related transcription factor RUNX2 modulates expression and secretion of the matricellular protein osteopontin in osteosarcoma cells to promote adhesion to endothelial pulmonary cells and lung metastasis. J Cell Physiol. 2019 08; 234(8):13659-13679.

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Rojas A, Sepulveda H, Henriquez B, Aguilar R, Opazo T, Nardocci G, Bustos F, Lian JB, Stein JL, Stein GS, van Zundert B, van Wijnen AJ, Allende ML, Montecino M. Mll-COMPASS complexes mediate H3K4me3 enrichment and transcription of the osteoblast master gene Runx2/p57 in osteoblasts. J Cell Physiol. 2019 05; 234(5):6244-6253.

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Araya HF, Sepulveda H, Lizama CO, Vega OA, Jerez S, Brice?o PF, Thaler R, Riester SM, Antonelli M, Salazar-Onfray F, Rodr?guez JP, Moreno RD, Montecino M, Charbonneau M, Dubois CM, Stein GS, van Wijnen AJ, Galindo MA. Expression of the ectodomain-releasing protease ADAM17 is directly regulated by the osteosarcoma and bone-related transcription factor RUNX2. J Cell Biochem. 2018 11; 119(10):8204-8219.

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Gillis NE, Taber TH, Bolf EL, Beaudet CM, Tomczak JA, White JH, Stein JL, Stein GS, Lian JB, Frietze S, Carr FE. Thyroid Hormone Receptor ? Suppression of RUNX2 Is Mediated by Brahma-Related Gene 1-Dependent Chromatin Remodeling. Endocrinology. 2018 06 01; 159(6):2484-2494.

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