"Receptor, TIE-2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A TIE receptor tyrosine kinase that is found almost exclusively on ENDOTHELIAL CELLS. It is required for both normal embryonic vascular development (NEOVASCULARIZATION, PHYSIOLOGIC) and tumor angiogenesis (NEOVASCULARIZATION, PATHOLOGIC).
| Descriptor ID |
D042787
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| MeSH Number(s) |
D08.811.913.696.620.682.725.400.925.500 D12.776.543.750.630.687.500
|
| Concept/Terms |
Receptor, TIE-2- Receptor, TIE-2
- Receptor, TIE 2
- TIE-2 Receptor
- TIE2 Tyrosine Kinase
- Tyrosine Kinase, TIE2
- TIE-2 Receptor Tyrosine Kinase
- TIE 2 Receptor Tyrosine Kinase
- Tek Receptor
- Receptor, Tek
- Tie2 Receptor
- Receptor, Tie2
- TIE-2-RTK
- Angiopoietin Receptor Tie-2
- Angiopoietin Receptor Tie 2
- Receptor Tie-2, Angiopoietin
- Tie-2, Angiopoietin Receptor
|
Below are MeSH descriptors whose meaning is more general than "Receptor, TIE-2".
Below are MeSH descriptors whose meaning is more specific than "Receptor, TIE-2".
This graph shows the total number of publications written about "Receptor, TIE-2" by people in this website by year, and whether "Receptor, TIE-2" was a major or minor topic of these publications.
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click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2004 | 0 | 1 | 1 |
| 2005 | 1 | 0 | 1 |
| 2008 | 1 | 0 | 1 |
| 2011 | 0 | 1 | 1 |
| 2014 | 1 | 0 | 1 |
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click here.
Below are the most recent publications written about "Receptor, TIE-2" by people in Profiles.
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Lieb W, Chen MH, Larson MG, Safa R, Teumer A, Baumeister SE, Lin H, Smith HM, Koch M, Lorbeer R, Völker U, Nauck M, Völzke H, Wallaschofski H, Sawyer DB, Vasan RS. Genome-wide association study for endothelial growth factors. Circ Cardiovasc Genet. 2015 Apr; 8(2):389-97.
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Mazzieri R, Pucci F, Moi D, Zonari E, Ranghetti A, Berti A, Politi LS, Gentner B, Brown JL, Naldini L, De Palma M. Targeting the ANG2/TIE2 axis inhibits tumor growth and metastasis by impairing angiogenesis and disabling rebounds of proangiogenic myeloid cells. Cancer Cell. 2011 Apr 12; 19(4):512-26.
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De Palma M, Mazzieri R, Politi LS, Pucci F, Zonari E, Sitia G, Mazzoleni S, Moi D, Venneri MA, Indraccolo S, Falini A, Guidotti LG, Galli R, Naldini L. Tumor-targeted interferon-alpha delivery by Tie2-expressing monocytes inhibits tumor growth and metastasis. Cancer Cell. 2008 Oct 07; 14(4):299-311.
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De Palma M, Venneri MA, Galli R, Sergi Sergi L, Politi LS, Sampaolesi M, Naldini L. Tie2 identifies a hematopoietic lineage of proangiogenic monocytes required for tumor vessel formation and a mesenchymal population of pericyte progenitors. Cancer Cell. 2005 Sep; 8(3):211-26.
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Shao R, Guo X. Human microvascular endothelial cells immortalized with human telomerase catalytic protein: a model for the study of in vitro angiogenesis. Biochem Biophys Res Commun. 2004 Sep 03; 321(4):788-94.