Proteasome Endopeptidase Complex

"Proteasome Endopeptidase Complex" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A large multisubunit complex that plays an important role in the degradation of most of the cytosolic and nuclear proteins in eukaryotic cells. It contains a 700-kDa catalytic sub-complex and two 700-kDa regulatory sub-complexes. The complex digests ubiquitinated proteins and protein activated via ornithine decarboxylase antizyme.

Descriptor ID	D046988
MeSH Number(s)	D05.500.562.500 D08.811.277.656.918 D08.811.600.730
Concept/Terms	Proteasome Endopeptidase Complex Proteasome Endopeptidase Complex Complex, Proteasome Endopeptidase Endopeptidase Complex, Proteasome Macropain Macroxyproteinase Multicatalytic Proteinase Proteinase, Multicatalytic Prosome Proteasome 20S Proteasome Proteasome, 20S Multicatalytic Endopeptidase Complex Complex, Multicatalytic Endopeptidase Endopeptidase Complex, Multicatalytic Ingensin Ingensin

Below are MeSH descriptors whose meaning is more general than "Proteasome Endopeptidase Complex".

Chemicals and Drugs [D]
Macromolecular Substances [D05]
Multiprotein Complexes [D05.500]
Multienzyme Complexes [D05.500.562]
Proteasome Endopeptidase Complex [D05.500.562.500]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Hydrolases [D08.811.277]
Peptide Hydrolases [D08.811.277.656]
Proteasome Endopeptidase Complex [D08.811.277.656.918]
Multienzyme Complexes [D08.811.600]
Proteasome Endopeptidase Complex [D08.811.600.730]

Below are MeSH descriptors whose meaning is related to "Proteasome Endopeptidase Complex".

Below are MeSH descriptors whose meaning is more specific than "Proteasome Endopeptidase Complex".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Proteasome Endopeptidase Complex" by people in this website by year, and whether "Proteasome Endopeptidase Complex" was a major or minor topic of these publications.

Bar chart showing 107 publications over 30 distinct years, with a maximum of 9 publications in 2013

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1995	1	4	5
1996	0	4	4
1997	0	4	4
1998	1	1	2
1999	0	5	5
2000	0	2	2
2001	1	2	3
2002	1	6	7
2003	0	3	3
2004	0	4	4
2005	2	0	2
2006	1	3	4
2007	3	2	5
2008	3	3	6
2009	2	4	6
2010	0	4	4
2011	3	1	4
2012	1	4	5
2013	6	3	9
2014	1	1	2
2015	1	2	3
2016	5	3	8
2017	1	0	1
2018	0	2	2
2019	1	0	1
2020	0	1	1
2021	0	1	1
2022	1	1	2
2023	0	1	1
2024	0	1	1

Below are the most recent publications written about "Proteasome Endopeptidase Complex" by people in Profiles.

Flynn JM, Joyce ME, Bolon DNA. Dominant negative mutations in yeast Hsp90 indicate triage decision mechanism targeting client proteins for degradation. Mol Biol Cell. 2025 Jan 01; 36(1):ar5.

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Arsenault HE, Benanti JA. Identification of Deubiquitinase Substrates in Saccharomyces cerevisiae by Systematic Overexpression. Methods Mol Biol. 2023; 2591:237-253.

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Garg S, Kreutzfeld O, Chelebieva S, Tumwebaze PK, Byaruhanga O, Okitwi M, Orena S, Katairo T, Nsobya SL, Conrad MD, Aydemir O, Legac J, Gould AE, Bayles BR, Bailey JA, Duffey M, Lin G, Kirkman LA, Cooper RA, Rosenthal PJ. Susceptibilities of Ugandan Plasmodium falciparum Isolates to Proteasome Inhibitors. Antimicrob Agents Chemother. 2022 10 18; 66(10):e0081722.

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Rushton MD, Saunderson EA, Patani H, Green MR, Ficz G. An shRNA kinase screen identifies regulators of UHRF1 stability and activity in mouse embryonic stem cells. Epigenetics. 2022 12; 17(12):1590-1607.

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Wang Y, Punzo C, Ash JD, Lobanova ES. Tsc2 knockout counteracts ubiquitin-proteasome system insufficiency and delays photoreceptor loss in retinitis pigmentosa. Proc Natl Acad Sci U S A. 2022 03 15; 119(11):e2118479119.

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M G MS, Chikhale R, Nanaware PP, Dalvi S, Venkatraman P. A druggable pocket on PSMD10Gankyrin that can accommodate an interface peptide and doxorubicin. Eur J Pharmacol. 2022 Jan 15; 915:174718.

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Wu PH, Zamore PD. To Degrade a MicroRNA, Destroy Its Argonaute Protein. Mol Cell. 2021 01 21; 81(2):223-225.

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Chatterjee P, Ponnapati M, Kramme C, Plesa AM, Church GM, Jacobson JM. Targeted intracellular degradation of SARS-CoV-2 via computationally optimized peptide fusions. Commun Biol. 2020 11 23; 3(1):715.

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Chiramel AI, Meyerson NR, McNally KL, Broeckel RM, Montoya VR, M?ndez-Sol?s O, Robertson SJ, Sturdevant GL, Lubick KJ, Nair V, Youseff BH, Ireland RM, Bosio CM, Kim K, Luban J, Hirsch VM, Taylor RT, Bouamr F, Sawyer SL, Best SM. TRIM5a Restricts Flavivirus Replication by Targeting the Viral Protease for Proteasomal Degradation. Cell Rep. 2019 06 11; 27(11):3269-3283.e6.

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Mapa CE, Arsenault HE, Conti MM, Poti KE, Benanti JA. A balance of deubiquitinating enzymes controls cell cycle entry. Mol Biol Cell. 2018 11 15; 29(23):2821-2834.

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