MAP Kinase Kinase 4

"MAP Kinase Kinase 4" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A mitogen-activated protein kinase kinase with specificity for JNK MITOGEN-ACTIVATED PROTEIN KINASES; P38 MITOGEN-ACTIVATED PROTEIN KINASES and the RETINOID X RECEPTORS. It takes part in a SIGNAL TRANSDUCTION pathway that is activated in response to cellular stress.

Descriptor ID	D048670
MeSH Number(s)	D08.811.913.696.620.682.700.565.400 D08.811.913.696.620.682.725.200.400 D12.644.360.440.400 D12.776.476.440.400
Concept/Terms	MAP Kinase Kinase 4 MAP Kinase Kinase 4 JN Kinase Kinase JNK Kinase Jun Amino-Terminal Kinase Kinase Jun Amino Terminal Kinase Kinase JNK-Activating Protein Kinase JNK Activating Protein Kinase Protein Kinase, JNK-Activating SAP Kinase-Extracellular Signal-Regulated Kinase Kinase 1 SAP Kinase Extracellular Signal Regulated Kinase Kinase 1 SEK1 Protein Kinase Protein Kinase, SEK1 Mitogen-Activated Protein Kinase Kinase 4 Mitogen Activated Protein Kinase Kinase 4 MEK4 Protein Kinase Protein Kinase, MEK4 JNKK1 Protein Kinase Kinase, JNKK1 Protein Protein Kinase, JNKK1 Stress-Activated Protein Kinase Kinase 1 Stress Activated Protein Kinase Kinase 1 SAPK-ERK Kinase 1 SAPK ERK Kinase 1 SAP Kinase Kinase 1

Below are MeSH descriptors whose meaning is more general than "MAP Kinase Kinase 4".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Transferases [D08.811.913]
Phosphotransferases [D08.811.913.696]
Phosphotransferases (Alcohol Group Acceptor) [D08.811.913.696.620]
Protein Kinases [D08.811.913.696.620.682]
Protein-Serine-Threonine Kinases [D08.811.913.696.620.682.700]
Mitogen-Activated Protein Kinase Kinases [D08.811.913.696.620.682.700.565]
MAP Kinase Kinase 4 [D08.811.913.696.620.682.700.565.400]
Protein-Tyrosine Kinases [D08.811.913.696.620.682.725]
Mitogen-Activated Protein Kinase Kinases [D08.811.913.696.620.682.725.200]
MAP Kinase Kinase 4 [D08.811.913.696.620.682.725.200.400]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intracellular Signaling Peptides and Proteins [D12.644.360]
Mitogen-Activated Protein Kinase Kinases [D12.644.360.440]
MAP Kinase Kinase 4 [D12.644.360.440.400]
Proteins [D12.776]
Intracellular Signaling Peptides and Proteins [D12.776.476]
Mitogen-Activated Protein Kinase Kinases [D12.776.476.440]
MAP Kinase Kinase 4 [D12.776.476.440.400]

Below are MeSH descriptors whose meaning is related to "MAP Kinase Kinase 4".

Below are MeSH descriptors whose meaning is more specific than "MAP Kinase Kinase 4".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "MAP Kinase Kinase 4" by people in this website by year, and whether "MAP Kinase Kinase 4" was a major or minor topic of these publications.

Bar chart showing 26 publications over 16 distinct years, with a maximum of 3 publications in 2014 and 2020

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2001	1	0	1
2002	1	1	2
2003	0	2	2
2004	0	2	2
2005	0	1	1
2007	1	0	1
2009	0	2	2
2012	0	1	1
2013	1	1	2
2014	2	1	3
2015	0	1	1
2016	1	0	1
2017	2	0	2
2020	0	3	3
2021	0	1	1
2022	0	1	1

Below are the most recent publications written about "MAP Kinase Kinase 4" by people in Profiles.

Vernia S, Lee A, Kennedy NJ, Han MS, Isasa M, Cavanagh-Kyros J, Roy A, Syed A, Chaudhry S, Edwards YJK, Gygi SP, Gao G, Davis RJ. Phosphorylation of RXRa mediates the effect of JNK to suppress hepatic FGF21 expression and promote metabolic syndrome. Proc Natl Acad Sci U S A. 2022 11; 119(44):e2210434119.

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Caliz AD, Yoo HJ, Vertii A, Dolan AC, Tournier C, Davis RJ, Keaney JF, Kant S. Mitogen Kinase Kinase (MKK7) Controls Cytokine Production In Vitro and In Vivo in Mice. Int J Mol Sci. 2021 Aug 29; 22(17).

View in: PubMed
Han MS, Perry RJ, Camporez JP, Scherer PE, Shulman GI, Gao G, Davis RJ. A feed-forward regulatory loop in adipose tissue promotes signaling by the hepatokine FGF21. Genes Dev. 2021 01 01; 35(1-2):133-146.

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Crespo M, Gonzalez-Teran B, Nikolic I, Mora A, Folgueira C, Rodr?guez E, Leiva-Vega L, Pintor-Chocano A, Fern?ndez-Chac?n M, Ruiz-Garrido I, Cicu?ndez B, Tom?s-Loba A, A-Gonzalez N, Caballero-Molano A, Beiroa D, Hern?ndez-Cosido L, Torres JL, Kennedy NJ, Davis RJ, Benedito R, Marcos M, Nogueiras R, Hidalgo A, Matesanz N, Leiva M, Sabio G. Neutrophil infiltration regulates clock-gene expression to organize daily hepatic metabolism. Elife. 2020 12 08; 9.

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Diwanji N, Bergmann A. Basement membrane damage by ROS- and JNK-mediated Mmp2 activation drives macrophage recruitment to overgrown tissue. Nat Commun. 2020 07 20; 11(1):3631.

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Craige SM, Chen K, Blanton RM, Keaney JF, Kant S. JNK and cardiometabolic dysfunction. Biosci Rep. 2019 07 31; 39(7).

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P?rez E, Lindblad JL, Bergmann A. Tumor-promoting function of apoptotic caspases by an amplification loop involving ROS, macrophages and JNK in Drosophila. Elife. 2017 08 30; 6.

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Fogarty CE, Bergmann A. Killers creating new life: caspases drive apoptosis-induced proliferation in tissue repair and disease. Cell Death Differ. 2017 08; 24(8):1390-1400.

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Han MS, Barrett T, Brehm MA, Davis RJ. Inflammation Mediated by JNK in Myeloid Cells Promotes the Development of Hepatitis and Hepatocellular Carcinoma. Cell Rep. 2016 Apr 05; 15(1):19-26.

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Yang J, Wu Z, Renier N, Simon DJ, Uryu K, Park DS, Greer PA, Tournier C, Davis RJ, Tessier-Lavigne M. Pathological axonal death through a MAPK cascade that triggers a local energy deficit. Cell. 2015 Jan 15; 160(1-2):161-76.

View in: PubMed

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