MAP Kinase Kinase 3

"MAP Kinase Kinase 3" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A mitogen-activated protein kinase kinase with specificity for a subset of P38 MITOGEN-ACTIVATED PROTEIN KINASES that includes MITOGEN-ACTIVATED PROTEIN KINASE 12; MITOGEN-ACTIVATED PROTEIN KINASE 13; and MITOGEN-ACTIVATED PROTEIN KINASE 14.

Descriptor ID	D048371
MeSH Number(s)	D08.811.913.696.620.682.700.565.300 D08.811.913.696.620.682.725.200.300 D12.644.360.440.300 D12.776.476.440.300
Concept/Terms	MAP Kinase Kinase 3 MAP Kinase Kinase 3 MEK3 Protein Kinase Protein Kinase, MEK3 MEK-3 Protein Kinase MEK 3 Protein Kinase MKK3 Protein Kinase Protein Kinase, MKK3 MKK-3 Protein Kinase MKK 3 Protein Kinase Protein Kinase, MKK-3 Dual Specificity Mitogen-Activated Protein Kinase Kinase 3 Dual Specificity Mitogen Activated Protein Kinase Kinase 3 Mitogen-Activated Protein Kinase Kinase 3 Mitogen Activated Protein Kinase Kinase 3

Below are MeSH descriptors whose meaning is more general than "MAP Kinase Kinase 3".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Transferases [D08.811.913]
Phosphotransferases [D08.811.913.696]
Phosphotransferases (Alcohol Group Acceptor) [D08.811.913.696.620]
Protein Kinases [D08.811.913.696.620.682]
Protein-Serine-Threonine Kinases [D08.811.913.696.620.682.700]
Mitogen-Activated Protein Kinase Kinases [D08.811.913.696.620.682.700.565]
MAP Kinase Kinase 3 [D08.811.913.696.620.682.700.565.300]
Protein-Tyrosine Kinases [D08.811.913.696.620.682.725]
Mitogen-Activated Protein Kinase Kinases [D08.811.913.696.620.682.725.200]
MAP Kinase Kinase 3 [D08.811.913.696.620.682.725.200.300]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intracellular Signaling Peptides and Proteins [D12.644.360]
Mitogen-Activated Protein Kinase Kinases [D12.644.360.440]
MAP Kinase Kinase 3 [D12.644.360.440.300]
Proteins [D12.776]
Intracellular Signaling Peptides and Proteins [D12.776.476]
Mitogen-Activated Protein Kinase Kinases [D12.776.476.440]
MAP Kinase Kinase 3 [D12.776.476.440.300]

Below are MeSH descriptors whose meaning is related to "MAP Kinase Kinase 3".

Below are MeSH descriptors whose meaning is more specific than "MAP Kinase Kinase 3".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "MAP Kinase Kinase 3" by people in this website by year, and whether "MAP Kinase Kinase 3" was a major or minor topic of these publications.

Bar chart showing 25 publications over 12 distinct years, with a maximum of 5 publications in 2005

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1998	0	1	1
2001	0	1	1
2002	0	3	3
2003	0	1	1
2005	2	3	5
2006	1	1	2
2007	2	2	4
2008	1	0	1
2009	1	0	1
2011	0	3	3
2012	0	1	1
2014	0	2	2

Below are the most recent publications written about "MAP Kinase Kinase 3" by people in Profiles.

Greenblatt MB, Kim JM, Oh H, Park KH, Choo MK, Sano Y, Tye CE, Skobe Z, Davis RJ, Park JM, Bei M, Glimcher LH, Shim JH. p38a MAPK is required for tooth morphogenesis and enamel secretion. J Biol Chem. 2015 Jan 02; 290(1):284-95.

View in: PubMed
Zaidi SK, Shen WJ, Bittner S, Bittner A, McLean MP, Han J, Davis RJ, Kraemer FB, Azhar S. p38 MAPK regulates steroidogenesis through transcriptional repression of STAR gene. J Mol Endocrinol. 2014 Aug; 53(1):1-16.

View in: PubMed
Gonz?lez-Ter?n B, Cort?s JR, Manieri E, Matesanz N, Verdugo ?, Rodr?guez ME, Gonz?lez-Rodr?guez ?, Valverde ?M, Valverde ?, Mart?n P, Davis RJ, Sabio G. Eukaryotic elongation factor 2 controls TNF-a translation in LPS-induced hepatitis. J Clin Invest. 2013 Jan; 123(1):164-78.

View in: PubMed
Lee J, Sun C, Zhou Y, Lee J, Gokalp D, Herrema H, Park SW, Davis RJ, Ozcan U. p38 MAPK-mediated regulation of Xbp1s is crucial for glucose homeostasis. Nat Med. 2011 Sep 04; 17(10):1251-60.

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Wen HC, Avivar-Valderas A, Sosa MS, Girnius N, Farias EF, Davis RJ, Aguirre-Ghiso JA. p38a Signaling Induces Anoikis and Lumen Formation During Mammary Morphogenesis. Sci Signal. 2011 May 24; 4(174):ra34.

View in: PubMed
Nagaleekar VK, Sabio G, Aktan I, Chant A, Howe IW, Thornton TM, Benoit PJ, Davis RJ, Rincon M, Boyson JE. Translational control of NKT cell cytokine production by p38 MAPK. J Immunol. 2011 Apr 01; 186(7):4140-6.

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Remy G, Risco AM, I?esta-Vaquera FA, Gonz?lez-Ter?n B, Sabio G, Davis RJ, Cuenda A. Differential activation of p38MAPK isoforms by MKK6 and MKK3. Cell Signal. 2010 Apr; 22(4):660-7.

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Fukuda K, Tesch GH, Yap FY, Forbes JM, Flavell RA, Davis RJ, Nikolic-Paterson DJ. MKK3 signalling plays an essential role in leukocyte-mediated pancreatic injury in the multiple low-dose streptozotocin model. Lab Invest. 2008 Apr; 88(4):398-407.

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Ma FY, Tesch GH, Flavell RA, Davis RJ, Nikolic-Paterson DJ. MKK3-p38 signaling promotes apoptosis and the early inflammatory response in the obstructed mouse kidney. Am J Physiol Renal Physiol. 2007 Nov; 293(5):F1556-63.

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Jaeschke A, Davis RJ. Metabolic stress signaling mediated by mixed-lineage kinases. Mol Cell. 2007 Aug 03; 27(3):498-508.

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