Phosphatidylinositol 3-Kinases

"Phosphatidylinositol 3-Kinases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Phosphotransferases that catalyzes the conversion of 1-phosphatidylinositol to 1-phosphatidylinositol 3-phosphate. Many members of this enzyme class are involved in RECEPTOR MEDIATED SIGNAL TRANSDUCTION and regulation of vesicular transport with the cell. Phosphatidylinositol 3-Kinases have been classified both according to their substrate specificity and their mode of action within the cell.

Descriptor ID	D019869
MeSH Number(s)	D08.811.913.696.620.500
Concept/Terms	Phosphatidylinositol 3-Kinases Phosphatidylinositol 3-Kinases Phosphatidylinositol 3 Kinases Phosphoinositide 3-Hydroxykinase PI 3-Kinase PtdIns 3-Kinases 3-Kinases, PtdIns PtdIns 3 Kinases PI-3K PI3 Kinases Kinases, PI3 PI3-Kinase PtdIns 3-Kinase Phosphatidylinositol-3-OH Kinase PI-3 Kinase

Below are MeSH descriptors whose meaning is more general than "Phosphatidylinositol 3-Kinases".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Transferases [D08.811.913]
Phosphotransferases [D08.811.913.696]
Phosphotransferases (Alcohol Group Acceptor) [D08.811.913.696.620]
Phosphatidylinositol 3-Kinases [D08.811.913.696.620.500]

Below are MeSH descriptors whose meaning is related to "Phosphatidylinositol 3-Kinases".

Below are MeSH descriptors whose meaning is more specific than "Phosphatidylinositol 3-Kinases".

Phosphatidylinositol 3-Kinases
Phosphatidylinositol 3-Kinase
Phosphatidylinositol-4-Phosphate 3-Kinase

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Phosphatidylinositol 3-Kinases" by people in this website by year, and whether "Phosphatidylinositol 3-Kinases" was a major or minor topic of these publications.

Bar chart showing 134 publications over 29 distinct years, with a maximum of 11 publications in 2005

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1993	0	1	1
1994	0	1	1
1995	0	2	2
1996	0	3	3
1997	2	2	4
1998	1	4	5
1999	0	1	1
2000	3	0	3
2001	3	4	7
2002	3	5	8
2003	1	7	8
2004	1	8	9
2005	4	7	11
2006	2	7	9
2007	0	6	6
2008	5	4	9
2009	0	5	5
2010	3	2	5
2011	1	1	2
2012	2	6	8
2013	2	1	3
2014	1	3	4
2015	0	5	5
2016	1	3	4
2017	0	1	1
2018	1	2	3
2019	1	1	2
2020	1	3	4
2022	0	1	1

Below are the most recent publications written about "Phosphatidylinositol 3-Kinases" by people in Profiles.

O'Leary BM. Guarding the gates: TOR mediates guard cell starch degradation to control stomatal opening. Plant Cell. 2022 03 04; 34(3):953-954.

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Clark P, Gee GV, Albright BS, Assetta B, Han Y, Atwood WJ, DiMaio D. Phosphoinositide 3'-Kinase ? Facilitates Polyomavirus Infection. Viruses. 2020 10 20; 12(10).

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Das A, Alshareef M, Porto GBF, Infinger LK, Vandergrift WA, Lindhorst SM, Varma AK, Patel SJ, Cachia D. Preconditioning with INC280 and LDK378 drugs sensitizes MGMT-unmethylated glioblastoma to temozolomide: Pre-clinical assessment. J Neurol Sci. 2020 Nov 15; 418:117102.

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Das A, Henderson FC, Alshareef M, Porto GBF, Kanginakudru I, Infinger LK, Vandergrift WA, Lindhorst SM, Varma AK, Patel SJ, Cachia D. MGMT-inhibitor in combination with TGF-?RI inhibitor or CDK 4/6 inhibitor increases temozolomide sensitivity in temozolomide-resistant glioblastoma cells. Clin Transl Oncol. 2021 Mar; 23(3):612-619.

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Das A, Martinez Santos JL, Alshareef M, Porto GBF, Infinger LK, Vandergrift WA, Lindhorst SM, Varma AK, Patel SJ, Cachia D. In Vitro Effect of Dovitinib (TKI258), a Multi-Target Angiokinase Inhibitor on Aggressive Meningioma Cells. Cancer Invest. 2020 Jul; 38(6):349-355.

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O'Leary BM, Oh GGK, Lee CP, Millar AH. Metabolite Regulatory Interactions Control Plant Respiratory Metabolism via Target of Rapamycin (TOR) Kinase Activation. Plant Cell. 2020 03; 32(3):666-682.

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Das A, Alshareef M, Henderson F, Martinez Santos JL, Vandergrift WA, Lindhorst SM, Varma AK, Infinger L, Patel SJ, Cachia D. Ganoderic acid A/DM-induced NDRG2 over-expression suppresses high-grade meningioma growth. Clin Transl Oncol. 2020 Jul; 22(7):1138-1145.

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Wu X, Song M, Cai X, Neto C, Tata A, Han Y, Wang Q, Tang Z, Xiao H. Chemopreventive Effects of Whole Cranberry (Vaccinium macrocarpon) on Colitis-Associated Colon Tumorigenesis. Mol Nutr Food Res. 2018 12; 62(24):e1800942.

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Mercado-Matos J, Janusis J, Zhu S, Chen SS, Shaw LM. Identification of a Novel Invasion-Promoting Region in Insulin Receptor Substrate 2. Mol Cell Biol. 2018 07 15; 38(14).

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Owino S, Sánchez-Bretaño A, Tchio C, Cecon E, Karamitri A, Dam J, Jockers R, Piccione G, Noh HL, Kim T, Kim JK, Baba K, Tosini G. Nocturnal activation of melatonin receptor type 1 signaling modulates diurnal insulin sensitivity via regulation of PI3K activity. J Pineal Res. 2018 Apr; 64(3).

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