CHMP5 is essential for late endosome function and down-regulation of receptor signaling during mouse embryogenesis.
Shim JH, Xiao C, Hayden MS, Lee KY, Trombetta ES, Pypaert M, Nara A, Yoshimori T, Wilm B, Erdjument-Bromage H, Tempst P, Hogan BL, Mellman I, Ghosh S. CHMP5 is essential for late endosome function and down-regulation of receptor signaling during mouse embryogenesis. J Cell Biol. 2006 Mar 27; 172(7):1045-56.
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Activin Receptors, Type I
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Amino Acid Sequence
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Animals
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Carrier Proteins
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Cell Line
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Cells, Cultured
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Down-Regulation
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Embryo, Mammalian
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Embryonic Development
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Endocytosis
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Endosomal Sorting Complexes Required for Transport
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Endosomes
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Gene Expression Regulation, Developmental
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Histocompatibility Antigens Class II
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Horseradish Peroxidase
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Intracellular Signaling Peptides and Proteins
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Lysosomes
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Mice
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Mice, Inbred C57BL
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Mice, Knockout
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Mice, Transgenic
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Molecular Sequence Data
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NIH 3T3 Cells
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Phenotype
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Phosphorylation
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Receptors, Transforming Growth Factor beta
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RNA, Small Interfering
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Sequence Homology, Amino Acid
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Signal Transduction
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Stem Cells
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Transfection