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Alisha M Gruntman DVM, PhD

TitleAssistant Professor
InstitutionUMass Chan Medical School
DepartmentPediatrics
AddressUniversity of Massachusetts Medical School
55 Lake Ave North
Worcester MA 01605
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    Other Positions
    InstitutionT.H. Chan School of Medicine
    DepartmentGene Therapy Center

    InstitutionT.H. Chan School of Medicine
    DepartmentPediatrics


    Collapse Biography 
    Collapse education and training
    Purdue University West Lafayette, West Lafayette, IN, United StatesDVMVeterinary Medicine
    University of Massachusetts Medical School, Worcester, MA, United StatesPHDGene Therapy

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Xie Q, Chen X, Ma H, Zhu Y, Ma Y, Jalinous L, Cox GF, Weaver F, Yang J, Kennedy Z, Gruntman A, Du A, Su Q, He R, Tai PW, Gao G, Xie J. Improved gene therapy for spinal muscular atrophy in mice using codon-optimized hSMN1 transgene and hSMN1 gene-derived promotor. EMBO Mol Med. 2024 Apr; 16(4):945-965. PMID: 38413838.
      Citations:    
    2. Blackwood M, Gruntman AM, Tang Q, Pires-Ferreira D, Reil D, Kondratov O, Marsic D, Zolotukhin S, Gernoux G, Keeler AM, Mueller C, Flotte TR. Biodistribution and safety of a single rAAV3B-AAT vector for silencing and replacement of alpha-1 antitrypsin in Cynomolgus macaques. Mol Ther Methods Clin Dev. 2024 Mar 14; 32(1):101200. PMID: 38445045.
      Citations:    
    3. Gruntman AM, Xue W, Flotte TR. Approaches to Therapeutic Gene Editing in Alpha-1 Antitrypsin Deficiency. Methods Mol Biol. 2024; 2750:11-17. PMID: 38108963.
      Citations:    Fields:    Translation:Humans
    4. Gruntman AM, Xue W, Flotte TR. Alpha-1 Antitrypsin Deficiency. Methods Mol Biol. 2024; 2750:1-7. PMID: 38108962.
      Citations:    Fields:    Translation:HumansCells
    5. Blackwood M, Tang Q, Gruntman AM. Serum Western Blot for the Detection of a c-Myc Protein Tag in Non-human Primates and Mice. Methods Mol Biol. 2024; 2750:107-112. PMID: 38108971.
      Citations:    Fields:    Translation:Animals
    6. Cabrera GT, Meijboom KE, Abdallah A, Tran H, Foster Z, Weiss A, Wightman N, Stock R, Gendron T, Gruntman A, Giampetruzzi A, Petrucelli L, Brown RH, Mueller C. Artificial microRNA suppresses C9ORF72 variants and decreases toxic dipeptide repeat proteins in vivo. Gene Ther. 2024 03; 31(3-4):105-118. PMID: 37752346.
      Citations: 1     Fields:    
    7. Pires Ferreira D, Gruntman AM, Flotte TR. Gene therapy for alpha-1 antitrypsin deficiency: an update. Expert Opin Biol Ther. 2023 03; 23(3):283-291. PMID: 36825473.
      Citations: 2     Fields:    Translation:Humans
    8. Shin M, Chan IL, Cao Y, Gruntman AM, Lee J, Sousa J, Rodr?guez TC, Echeverria D, Devi G, Debacker AJ, Moazami MP, Krishnamurthy PM, Rembetsy-Brown JM, Kelly K, Yukselen O, Donnard E, Parsons TJ, Khvorova A, Sontheimer EJ, Maehr R, Garber M, Watts JK. Intratracheally administered LNA gapmer antisense oligonucleotides induce robust gene silencing in mouse lung fibroblasts. Nucleic Acids Res. 2022 08 26; 50(15):8418-8430. PMID: 35920332.
      Citations: 6     Fields:    Translation:AnimalsCells
    9. Gruntman AM, Flotte TR. Gene Therapy and the Use of Animal Models: Why Mice Alone Are Not Sufficient. Hum Gene Ther. 2022 05; 33(9-10):477-478. PMID: 35576406.
      Citations: 1     Fields:    Translation:Animals
    10. Arjomandnejad M, Sylvia K, Blackwood M, Nixon T, Tang Q, Muhuri M, Gruntman AM, Gao G, Flotte TR, Keeler AM. Modulating immune responses to AAV by expanded polyclonal T-regs and capsid specific chimeric antigen receptor T-regulatory cells. Mol Ther Methods Clin Dev. 2021 Dec 10; 23:490-506. PMID: 34853797.
      Citations:    
    11. Dixon CE, Kelley D, Froehlich JM, Gruntman A, Oura T, Mazan MR, Labato MA. Therapeutic plasma exchange to mitigate flunixin meglumine overdose in a cria. J Vet Emerg Crit Care (San Antonio). 2021 Jul; 31(4):521-524. PMID: 33955631.
      Citations:    Fields:    Translation:Animals
    12. Gernoux G, Gruntman AM, Blackwood M, Zieger M, Flotte TR, Mueller C. Muscle-Directed Delivery of an AAV1 Vector Leads to Capsid-Specific T Cell Exhaustion in Nonhuman Primates and Humans. Mol Ther. 2020 03 04; 28(3):747-757. PMID: 31982038.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    13. Gruntman AM, Gernoux G, Tang Q, Ye GJ, Knop DR, Wang G, Benson J, Coleman KE, Keeler AM, Mueller C, Chicoine LG, Chulay JD, Flotte TR. Bridging from Intramuscular to Limb Perfusion Delivery of rAAV: Optimization in a Non-human Primate Study. Mol Ther Methods Clin Dev. 2019 Jun 14; 13:233-242. PMID: 30828586.
      Citations:    
    14. Gruntman AM, Flotte TR. The rapidly evolving state of gene therapy. FASEB J. 2018 04; 32(4):1733-1740. PMID: 31282760.
      Citations: 17     Fields:    Translation:HumansCells
    15. Borel F, Sun H, Zieger M, Cox A, Cardozo B, Li W, Oliveira G, Davis A, Gruntman A, Flotte TR, Brodsky MH, Hoffman AM, Elmallah MK, Mueller C. Editing out five Serpina1 paralogs to create a mouse model of genetic emphysema. Proc Natl Acad Sci U S A. 2018 03 13; 115(11):2788-2793. PMID: 29453277.
      Citations: 43     Fields:    Translation:HumansAnimals
    16. Mueller C, Gernoux G, Gruntman AM, Borel F, Reeves EP, Calcedo R, Rouhani FN, Yachnis A, Humphries M, Campbell-Thompson M, Messina L, Chulay JD, Trapnell B, Wilson JM, McElvaney NG, Flotte TR. 5 Year Expression and Neutrophil Defect Repair after Gene Therapy in Alpha-1 Antitrypsin Deficiency. Mol Ther. 2017 06 07; 25(6):1387-1394. PMID: 28408179.
      Citations: 51     Fields:    Translation:HumansCells
    17. Gruntman AM, Su L, Flotte TR. Retro-Orbital Venous Sinus Delivery of rAAV9 Mediates High-Level Transduction of Brain and Retina Compared with Temporal Vein Delivery in Neonatal Mouse Pups. Hum Gene Ther. 2017 03; 28(3):228-230. PMID: 28319444.
      Citations: 9     Fields:    Translation:AnimalsCells
    18. Gruntman AM. Genotyping Protocol for the Alpha-1 Antitrypsin (PiZ) Mouse Model. Methods Mol Biol. 2017; 1639:61-65. PMID: 28752446.
      Citations:    Fields:    Translation:Animals
    19. Gruntman AM, Flotte TR. Therapeutics: Gene Therapy for Alpha-1 Antitrypsin Deficiency. Methods Mol Biol. 2017; 1639:267-275. PMID: 28752467.
      Citations: 4     Fields:    Translation:Humans
    20. Tang Q, Gruntman AM, Flotte TR. Quantification of Total Human Alpha-1 Antitrypsin by Sandwich ELISA. Methods Mol Biol. 2017; 1639:211-216. PMID: 28752460.
      Citations: 2     Fields:    Translation:Humans
    21. Gruntman AM, Flotte TR. Delivery of Adeno-Associated Virus Gene Therapy by Intravascular Limb Infusion Methods. Hum Gene Ther Clin Dev. 2015 Sep; 26(3):159-64. PMID: 26357010.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    22. Gruntman AM, Flotte TR. Progress with Recombinant Adeno-Associated Virus Vectors for Gene Therapy of Alpha-1 Antitrypsin Deficiency. Hum Gene Ther Methods. 2015 Jun; 26(3):77-81. PMID: 26067712.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    23. Gruntman AM, Su L, Su Q, Gao G, Mueller C, Flotte TR. Stability and compatibility of recombinant adeno-associated virus under conditions commonly encountered in human gene therapy trials. Hum Gene Ther Methods. 2015 Apr; 26(2):71-6. PMID: 25819833.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    24. Paxson JA, Gruntman AM, Davis AM, Parkin CM, Ingenito EP, Hoffman AM. Age dependence of lung mesenchymal stromal cell dynamics following pneumonectomy. Stem Cells Dev. 2013 Dec 15; 22(24):3214-25. PMID: 23895415.
      Citations: 14     Fields:    Translation:AnimalsCells
    25. Gruntman AM, Bish LT, Mueller C, Sweeney HL, Flotte TR, Gao G. Gene transfer in skeletal and cardiac muscle using recombinant adeno-associated virus. Curr Protoc Microbiol. 2013; Chapter 14:Unit 14D.3. PMID: 23408131.
      Citations: 16     Fields:    Translation:AnimalsCells
    26. Gruntman AM, Mueller C, Flotte TR, Gao G. Gene transfer in the lung using recombinant adeno-associated virus. Curr Protoc Microbiol. 2012 Aug; Chapter 14:Unit14D.2. PMID: 22875566.
      Citations: 9     Fields:    Translation:AnimalsCells
    27. Mueller C, Tang Q, Gruntman A, Blomenkamp K, Teckman J, Song L, Zamore PD, Flotte TR. Sustained miRNA-mediated knockdown of mutant AAT with simultaneous augmentation of wild-type AAT has minimal effect on global liver miRNA profiles. Mol Ther. 2012 03; 20(3):590-600. PMID: 22252449.
      Citations: 54     Fields:    Translation:HumansAnimalsCells
    28. Paxson JA, Gruntman A, Parkin CD, Mazan MR, Davis A, Ingenito EP, Hoffman AM. Age-dependent decline in mouse lung regeneration with loss of lung fibroblast clonogenicity and increased myofibroblastic differentiation. PLoS One. 2011; 6(8):e23232. PMID: 21912590.
      Citations: 28     Fields:    Translation:AnimalsCells
    29. Melidone R, Parry NM, Gruntman A. Urinary bladder agenesis in an alpaca (Vicugna pacos) cria. J Vet Diagn Invest. 2010 May; 22(3):473-5. PMID: 20453232.
      Citations:    Fields:    Translation:Animals
    30. Rosenthal FS, Gruntman A, Couetil LL. A comparison of total, respirable, and real-time airborne particulate sampling in horse barns. J Occup Environ Hyg. 2006 Nov; 3(11):599-605. PMID: 17086664.
      Citations: 10     Fields:    Translation:AnimalsPHPublic Health
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