Pyroptosis

"Pyroptosis" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Type of programmed cell death associated with infection by intracellular pathogens. It is characterized by INFLAMMASOME formation; activation of CASPASE 1; and CYTOKINES mediated inflammation.

Descriptor ID	D000069292
MeSH Number(s)	G04.146.160.530
Concept/Terms	Pyroptosis Pyroptosis Pyroptoses Pyroptotic Cell Death Cell Death, Pyroptotic Cell Deaths, Pyroptotic Death, Pyroptotic Cell Deaths, Pyroptotic Cell Pyroptotic Cell Deaths Inflammatory Apoptosis Apoptoses, Inflammatory Apoptosis, Inflammatory Inflammatory Apoptoses Caspase-1 Dependent Cell Death Caspase 1 Dependent Cell Death

Below are MeSH descriptors whose meaning is more general than "Pyroptosis".

Biological Sciences [G]
Cell Physiological Phenomena [G04]
Cell Death [G04.146]
Apoptosis [G04.146.160]
Pyroptosis [G04.146.160.530]

Below are MeSH descriptors whose meaning is related to "Pyroptosis".

Below are MeSH descriptors whose meaning is more specific than "Pyroptosis".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Pyroptosis" by people in this website by year, and whether "Pyroptosis" was a major or minor topic of these publications.

Bar chart showing 23 publications over 8 distinct years, with a maximum of 7 publications in 2021

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2019	1	2	3
2020	2	2	4
2021	4	3	7
2022	1	0	1
2023	1	2	3
2024	1	2	3
2025	1	0	1
2026	0	1	1

Below are the most recent publications written about "Pyroptosis" by people in Profiles.

de Farias IS, Duarte-Barbosa M, Salazar N, Andreata-Santos R, de Lucena VWL, Maricato JT, Gazzinelli RT, Janini LMR, Bortoluci KR. NLRP3 inflammasome activation in astrocytes restricts SARS-CoV-2 through gasdermin-D-driven IL-1? release. Front Immunol. 2025; 16:1703765.

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Zhang B, Orning P, Lehman JW, Dinis A, Torres-Ulloa L, Elling R, Kelliher MA, Bertin J, Proulx MK, Goguen JD, Ryan L, Kandasamy RK, Espevik T, Pai AA, Fitzgerald KA, Lien E. Raver1 links Ripk1 RNA splicing to caspase-8-mediated pyroptotic cell death, inflammation, and pathogen resistance. Proc Natl Acad Sci U S A. 2025 Feb 18; 122(7):e2420802122.

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Wang Y, Zhang Y, Kim K, Han J, Okin D, Jiang Z, Yang L, Subramaniam A, Means TK, Nestl? FO, Fitzgerald KA, Randolph GJ, Lesser CF, Kagan JC, Mathis D, Benoist C. A pan-family screen of nuclear receptors in immunocytes reveals ligand-dependent inflammasome control. Immunity. 2024 12 10; 57(12):2737-2754.e12.

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Jena KK, Mambu J, Boehmer D, Sposito B, Millet V, de Sousa Casal J, Muendlein HI, Spreafico R, Fenouil R, Spinelli L, Wurbel S, Riquier C, Galland F, Naquet P, Chasson L, Elkins M, Mitsialis V, Ketelut-Carneiro N, Bugda Gwilt K, Thiagarajah JR, Ruan HB, Lin Z, Lien E, Shao F, Chou J, Poltorak A, Ordovas-Montanes J, Fitzgerald KA, Snapper SB, Broggi A, Zanoni I. Type III interferons induce pyroptosis in gut epithelial cells and impair mucosal repair. Cell. 2024 Dec 26; 187(26):7533-7550.e23.

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Stine L, Humphries F. Gasdermin D palmitoylation: to cleave or not to cleave? Trends Immunol. 2024 06; 45(6):403-405.

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Orzalli MH. An orphan no more: Nur77 senses cytosolic LPS. Immunity. 2023 04 11; 56(4):742-744.

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Ye Q, Wang Q, Lee W, Xiang Y, Yuan J, Zhang Y, Guo X. A Pore Forming Toxin-like Protein Derived from Chinese Red Belly Toad Bombina maxima Triggers the Pyroptosis of Hippomal Neural Cells and Impairs the Cognitive Ability of Mice. Toxins (Basel). 2023 03 03; 15(3).

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Humphries F. Biochemical Methods for Assessing Gasdermin D Inactivation in Macrophages. Methods Mol Biol. 2023; 2641:125-133.

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Shao F, Fitzgerald KA. Molecular mechanisms and functions of pyroptosis. J Mol Biol. 2022 Feb 28; 434(4):167461.

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Ketelut-Carneiro N, Fitzgerald KA. Apoptosis, Pyroptosis, and Necroptosis-Oh My! The Many Ways a Cell Can Die. J Mol Biol. 2022 02 28; 434(4):167378.

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