Chitinase-3-Like Protein 1
"Chitinase-3-Like Protein 1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A lectin that binds CHITIN, but lacks chitinase activity. It may be involved in tissue remodeling and cellular responses to the environment, including the response of type 2 HELPER T-CELLS to INFLAMMATION and sensitization to ALLERGENS. Mutations in the CHI3L1 gene are associated with ASTHMA.
| Descriptor ID |
D000071451
|
| MeSH Number(s) |
D08.811.277.450.207.500 D12.776.503.070
|
| Concept/Terms |
Chitinase-3-Like Protein 1- Chitinase-3-Like Protein 1
- Chitinase 3 Like Protein 1
- Cartilage Glycoprotein 39
- Glycoprotein 39, Cartilage
- GP-39 Protein
- GP 39 Protein
- YLK-40 Protein
- YLK 40 Protein
- CHI3L1 Protein
- CGP-39 Protein
- CGP 39 Protein
|
Below are MeSH descriptors whose meaning is more general than "Chitinase-3-Like Protein 1".
Below are MeSH descriptors whose meaning is more specific than "Chitinase-3-Like Protein 1".
This graph shows the total number of publications written about "Chitinase-3-Like Protein 1" by people in this website by year, and whether "Chitinase-3-Like Protein 1" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2009 | 0 | 1 | 1 |
| 2011 | 0 | 4 | 4 |
| 2012 | 0 | 1 | 1 |
| 2017 | 1 | 0 | 1 |
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Below are the most recent publications written about "Chitinase-3-Like Protein 1" by people in Profiles.
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Ngernyuang N, Yan W, Schwartz LM, Oh D, Liu YB, Chen H, Shao R. A Heparin Binding Motif Rich in Arginine and Lysine is the Functional Domain of YKL-40. Neoplasia. 2018 02; 20(2):182-192.
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Montgomery TA, Xu L, Mason S, Chinnadurai A, Lee CG, Elias JA, Cantley LG. Breast Regression Protein-39/Chitinase 3-Like 1 Promotes Renal Fibrosis after Kidney Injury via Activation of Myofibroblasts. J Am Soc Nephrol. 2017 Nov; 28(11):3218-3226.
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Shao R, Francescone R, Ngernyuang N, Bentley B, Taylor SL, Moral L, Yan W. Anti-YKL-40 antibody and ionizing irradiation synergistically inhibit tumor vascularization and malignancy in glioblastoma. Carcinogenesis. 2014 Feb; 35(2):373-82.
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Arcaro KF, Browne EP, Qin W, Zhang K, Anderton DL, Sauter ER. Differential expression of cancer-related proteins in paired breast milk samples from women with breast cancer. J Hum Lact. 2012 Nov; 28(4):543-6.
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Scully S, Yan W, Bentley B, Cao QJ, Shao R. Inhibitory activity of YKL-40 in mammary epithelial cell differentiation and polarization induced by lactogenic hormones: a role in mammary tissue involution. PLoS One. 2011; 6(10):e25819.
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Shao R, Cao QJ, Arenas RB, Bigelow C, Bentley B, Yan W. Breast cancer expression of YKL-40 correlates with tumour grade, poor differentiation, and other cancer markers. Br J Cancer. 2011 Oct 11; 105(8):1203-9.
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Francescone RA, Scully S, Faibish M, Taylor SL, Oh D, Moral L, Yan W, Bentley B, Shao R. Role of YKL-40 in the angiogenesis, radioresistance, and progression of glioblastoma. J Biol Chem. 2011 Apr 29; 286(17):15332-43.
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Faibish M, Francescone R, Bentley B, Yan W, Shao R. A YKL-40-neutralizing antibody blocks tumor angiogenesis and progression: a potential therapeutic agent in cancers. Mol Cancer Ther. 2011 May; 10(5):742-51.
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Shao R, Hamel K, Petersen L, Cao QJ, Arenas RB, Bigelow C, Bentley B, Yan W. YKL-40, a secreted glycoprotein, promotes tumor angiogenesis. Oncogene. 2009 Dec 17; 28(50):4456-68.
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Kamal SM, Turner B, He Q, Rasenack J, Bianchi L, Al Tawil A, Nooman A, Massoud M, Koziel MJ, Afdhal NH. Progression of fibrosis in hepatitis C with and without schistosomiasis: correlation with serum markers of fibrosis. Hepatology. 2006 Apr; 43(4):771-9.