Nonsense Mediated mRNA Decay
"Nonsense Mediated mRNA Decay" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An mRNA metabolic process that distinguishes a normal STOP CODON from a premature stop codon (NONSENSE CODON) and facilitates rapid degradation of aberrant mRNAs containing premature stop codons.
| Descriptor ID |
D059365
|
| MeSH Number(s) |
G02.111.760.112 G02.111.780.500 G03.839.112 G05.308.700.112
|
| Concept/Terms |
Nonsense Mediated mRNA Decay- Nonsense Mediated mRNA Decay
- Nonsense-Mediated mRNA Decay
- Decay, Nonsense-Mediated mRNA
- mRNA Decay, Nonsense-Mediated
|
Below are MeSH descriptors whose meaning is more general than "Nonsense Mediated mRNA Decay".
Below are MeSH descriptors whose meaning is more specific than "Nonsense Mediated mRNA Decay".
This graph shows the total number of publications written about "Nonsense Mediated mRNA Decay" by people in this website by year, and whether "Nonsense Mediated mRNA Decay" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2012 | 0 | 2 | 2 |
| 2013 | 1 | 1 | 2 |
| 2015 | 1 | 0 | 1 |
| 2016 | 0 | 1 | 1 |
| 2017 | 2 | 0 | 2 |
| 2018 | 0 | 1 | 1 |
| 2020 | 1 | 1 | 2 |
| 2021 | 1 | 0 | 1 |
| 2022 | 1 | 2 | 3 |
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Below are the most recent publications written about "Nonsense Mediated mRNA Decay" by people in Profiles.
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Ganesan R, Mangkalaphiban K, Baker RE, He F, Jacobson A. Ribosome-bound Upf1 forms distinct 80S complexes and conducts mRNA surveillance. RNA. 2022 12; 28(12):1621-1642.
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He F, Wu C, Jacobson A. Dcp2 C-terminal cis-binding elements control selective targeting of the decapping enzyme by forming distinct decapping complexes. Elife. 2022 05 23; 11.
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Wang J, Zhang Y, Mendonca CA, Yukselen O, Muneeruddin K, Ren L, Liang J, Zhou C, Xie J, Li J, Jiang Z, Kucukural A, Shaffer SA, Gao G, Wang D. AAV-delivered suppressor tRNA overcomes a nonsense mutation in mice. Nature. 2022 04; 604(7905):343-348.
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Kovalak C, Donovan S, Bicknell AA, Metkar M, Moore MJ. Deep sequencing of pre-translational mRNPs reveals hidden flux through evolutionarily conserved alternative splicing nonsense-mediated decay pathways. Genome Biol. 2021 05 03; 22(1):132.
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Wu C, Roy B, He F, Yan K, Jacobson A. Poly(A)-Binding Protein Regulates the Efficiency of Translation Termination. Cell Rep. 2020 11 17; 33(7):108399.
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Gerbracht JV, Boehm V, Britto-Borges T, Kallabis S, Wiederstein JL, Ciriello S, Aschemeier DU, Kr?ger M, Frese CK, Altm?ller J, Dieterich C, Gehring NH. CASC3 promotes transcriptome-wide activation of nonsense-mediated decay by the exon junction complex. Nucleic Acids Res. 2020 09 04; 48(15):8626-8644.
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Ganesan R, Leszyk J, Jacobson A. Selective profiling of ribosomes associated with yeast Upf proteins. Methods. 2019 02 15; 155:58-67.
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Bosco DA. Translation dysregulation in neurodegenerative disorders. Proc Natl Acad Sci U S A. 2018 12 18; 115(51):12842-12844.
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Celik A, He F, Jacobson A. NMD monitors translational fidelity 24/7. Curr Genet. 2017 Dec; 63(6):1007-1010.
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Celik A, Baker R, He F, Jacobson A. High-resolution profiling of NMD targets in yeast reveals translational fidelity as a basis for substrate selection. RNA. 2017 05; 23(5):735-748.