Endoplasmic Reticulum-Associated Degradation
"Endoplasmic Reticulum-Associated Degradation" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A degradation process whereby incorrectly folded proteins are selectively transported out of the ENDOPLASMIC RETICULUM and into the CYTOSOL. The misfolded proteins are subsequently ubiquitinated and degraded by the PROTEASOME.
Descriptor ID |
D060746
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MeSH Number(s) |
G02.111.660.871.790.600.962.500 G02.111.691.600.850.500 G03.734.871.790.600.850.500 G05.308.670.600.850.500
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Concept/Terms |
Endoplasmic Reticulum-Associated Degradation- Endoplasmic Reticulum-Associated Degradation
- Degradation, Endoplasmic Reticulum-Associated
- Endoplasmic Reticulum Associated Degradation
- Reticulum-Associated Degradation, Endoplasmic
- ERAD Pathway
- ERAD Pathways
- Pathway, ERAD
- Pathways, ERAD
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Below are MeSH descriptors whose meaning is more general than "Endoplasmic Reticulum-Associated Degradation".
Below are MeSH descriptors whose meaning is more specific than "Endoplasmic Reticulum-Associated Degradation".
This graph shows the total number of publications written about "Endoplasmic Reticulum-Associated Degradation" by people in this website by year, and whether "Endoplasmic Reticulum-Associated Degradation" was a major or minor topic of these publications.
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Year | Major Topic | Minor Topic | Total |
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2016 | 0 | 1 | 1 |
2018 | 1 | 0 | 1 |
2022 | 1 | 1 | 2 |
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Below are the most recent publications written about "Endoplasmic Reticulum-Associated Degradation" by people in Profiles.
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Lv B, Zhang XO, Pazour GJ. Arih2 regulates Hedgehog signaling through smoothened ubiquitylation and ER-associated degradation. J Cell Sci. 2022 08 15; 135(16).
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Song YB, Park SY, Park K, Hwang H, Carroll RS, Hsu VW, Kaiser UB. Trafficking-defective mutant PROKR2 cycles between endoplasmic reticulum and Golgi to attenuate endoplasmic reticulum stress. Proc Natl Acad Sci U S A. 2022 02 22; 119(8).
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Roder K, Kabakov A, Moshal KS, Murphy KR, Xie A, Dudley S, Turan NN, Lu Y, MacRae CA, Koren G. Trafficking of the human ether-a-go-go-related gene (hERG) potassium channel is regulated by the ubiquitin ligase rififylin (RFFL). J Biol Chem. 2019 01 04; 294(1):351-360.
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Cherepanova N, Shrimal S, Gilmore R. N-linked glycosylation and homeostasis of the endoplasmic reticulum. Curr Opin Cell Biol. 2016 08; 41:57-65.