Unfolded Protein Response
"Unfolded Protein Response" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A cellular response to environmental insults that cause disruptions in PROTEIN FOLDING and/or accumulation of defectively folded protein in the ENDOPLASMIC RETICULUM. It consists of a group of regulatory cascades that are triggered as a response to altered levels of calcium and/or the redox state of the endoplasmic reticulum. Persistent activation of the unfolded protein response leads to the induction of APOPTOSIS.
| Descriptor ID |
D056811
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| MeSH Number(s) |
G02.111.660.871.790.600.962 G02.111.691.600.850 G03.734.871.790.600.850 G05.308.670.600.850
|
| Concept/Terms |
Unfolded Protein Response- Unfolded Protein Response
- Protein Response, Unfolded
- Protein Responses, Unfolded
- Response, Unfolded Protein
- Responses, Unfolded Protein
- Unfolded Protein Responses
|
Below are MeSH descriptors whose meaning is more general than "Unfolded Protein Response".
Below are MeSH descriptors whose meaning is more specific than "Unfolded Protein Response".
This graph shows the total number of publications written about "Unfolded Protein Response" by people in this website by year, and whether "Unfolded Protein Response" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2009 | 2 | 0 | 2 |
| 2010 | 4 | 2 | 6 |
| 2011 | 1 | 1 | 2 |
| 2012 | 2 | 1 | 3 |
| 2013 | 2 | 1 | 3 |
| 2014 | 1 | 0 | 1 |
| 2015 | 5 | 1 | 6 |
| 2016 | 3 | 1 | 4 |
| 2017 | 6 | 0 | 6 |
| 2018 | 2 | 2 | 4 |
| 2019 | 3 | 0 | 3 |
| 2020 | 1 | 0 | 1 |
| 2021 | 0 | 1 | 1 |
| 2022 | 0 | 2 | 2 |
| 2024 | 1 | 1 | 2 |
| 2025 | 1 | 1 | 2 |
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click here.
Below are the most recent publications written about "Unfolded Protein Response" by people in Profiles.
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Yin X, Wang R, Thackeray A, Baehrecke EH, Alkema MJ. VPS13D mutations affect mitochondrial homeostasis and locomotion in Caenorhabditis elegans. G3 (Bethesda). 2025 Apr 17; 15(4).
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Pullen KM, Finethy R, Ko SB, Reames CJ, Sassetti CM, Lauffenburger DA. Cross-species transcriptomics translation reveals a role for the unfolded protein response in Mycobacterium tuberculosis infection. NPJ Syst Biol Appl. 2025 Feb 15; 11(1):19.
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Mallick A, Haynes CM. Methods to analyze the mitochondrial unfolded protein response (UPRmt). Methods Enzymol. 2024; 707:543-564.
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Kim S, Ramalho TR, Haynes CM. Regulation of proteostasis and innate immunity via mitochondria-nuclear communication. J Cell Biol. 2024 03 04; 223(3).
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Uma Naresh N, Kim S, Shpilka T, Yang Q, Du Y, Haynes CM. Mitochondrial genome recovery by ATFS-1 is essential for development after starvation. Cell Rep. 2022 12 27; 41(13):111875.
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Haynes CM, Hekimi S. Mitochondrial dysfunction, aging, and the mitochondrial unfolded protein response in Caenorhabditis elegans. Genetics. 2022 11 30; 222(4).
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Sharma RB, Landa-Galv?n HV, Alonso LC. Living Dangerously: Protective and Harmful ER Stress Responses in Pancreatic ?-Cells. Diabetes. 2021 11; 70(11):2431-2443.
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Charbord J, Ren L, Sharma RB, Johansson A, ?gren R, Chu L, Tworus D, Schulz N, Charbord P, Stewart AF, Wang P, Alonso LC, Andersson O. In vivo screen identifies a SIK inhibitor that induces ? cell proliferation through a transient UPR. Nat Metab. 2021 05; 3(5):682-700.
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Shpilka T, Du Y, Yang Q, Melber A, Uma Naresh N, Lavelle J, Kim S, Liu P, Weidberg H, Li R, Yu J, Zhu LJ, Strittmatter L, Haynes CM. UPRmt scales mitochondrial network expansion with protein synthesis via mitochondrial import in Caenorhabditis elegans. Nat Commun. 2021 01 20; 12(1):479.
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Anderson NS, Haynes CM. Folding the Mitochondrial UPR into the Integrated Stress Response. Trends Cell Biol. 2020 06; 30(6):428-439.