Unfolded Protein Response

"Unfolded Protein Response" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A cellular response to environmental insults that cause disruptions in PROTEIN FOLDING and/or accumulation of defectively folded protein in the ENDOPLASMIC RETICULUM. It consists of a group of regulatory cascades that are triggered as a response to altered levels of calcium and/or the redox state of the endoplasmic reticulum. Persistent activation of the unfolded protein response leads to the induction of APOPTOSIS.

Descriptor ID	D056811
MeSH Number(s)	G02.111.660.871.790.600.962 G02.111.691.600.850 G03.734.871.790.600.850 G05.308.670.600.850
Concept/Terms	Unfolded Protein Response Unfolded Protein Response Protein Response, Unfolded Protein Responses, Unfolded Response, Unfolded Protein Responses, Unfolded Protein Unfolded Protein Responses

Below are MeSH descriptors whose meaning is more general than "Unfolded Protein Response".

Biological Sciences [G]
Chemical Phenomena [G02]
Biochemical Phenomena [G02.111]
Peptide Biosynthesis [G02.111.660]
Protein Biosynthesis [G02.111.660.871]
Protein Modification, Translational [G02.111.660.871.790]
Protein Processing, Post-Translational [G02.111.660.871.790.600]
Unfolded Protein Response [G02.111.660.871.790.600.962]
Protein Modification, Translational [G02.111.691]
Protein Processing, Post-Translational [G02.111.691.600]
Unfolded Protein Response [G02.111.691.600.850]
Metabolism [G03]
Peptide Biosynthesis [G03.734]
Protein Biosynthesis [G03.734.871]
Protein Modification, Translational [G03.734.871.790]
Protein Processing, Post-Translational [G03.734.871.790.600]
Unfolded Protein Response [G03.734.871.790.600.850]
Genetic Phenomena [G05]
Gene Expression Regulation [G05.308]
Protein Modification, Translational [G05.308.670]
Protein Processing, Post-Translational [G05.308.670.600]
Unfolded Protein Response [G05.308.670.600.850]

Below are MeSH descriptors whose meaning is related to "Unfolded Protein Response".

Below are MeSH descriptors whose meaning is more specific than "Unfolded Protein Response".

Unfolded Protein Response
Endoplasmic Reticulum-Associated Degradation

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Unfolded Protein Response" by people in this website by year, and whether "Unfolded Protein Response" was a major or minor topic of these publications.

Bar chart showing 52 publications over 17 distinct years, with a maximum of 6 publications in 2010 and 2015 and 2016 and 2017

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2009	2	0	2
2010	4	2	6
2011	1	1	2
2012	2	1	3
2013	2	1	3
2014	1	0	1
2015	5	1	6
2016	3	3	6
2017	6	0	6
2018	2	2	4
2019	3	0	3
2020	1	0	1
2021	0	1	1
2022	0	2	2
2024	1	1	2
2025	2	1	3
2026	0	1	1

Below are the most recent publications written about "Unfolded Protein Response" by people in Profiles.

Valenzuela-Villatoro M, de la Cruz-Ruiz P, Guerrero-G?mez D, G?mez-Orte E, Schiavi A, Maglioni S, Montero M, Fonteriz RI, Casas-Mart?nez JC, Briand NE, Xu J, Rodriguez-Palero MJ, Artal-Sanz M, Olek K, Polaczyk J, Turek M, Pokrzywa W, Xu S, Irazoqui JE, McDonagh B, ?lvarez J, Olmedo M, Ventura N, Cabello J, Miranda-Vizuete A. Mitochondrial redox homeostasis links organellar stress surveillance to germline and somatic integrity in Caenorhabditis elegans. Redox Biol. 2026 Jun; 93:104115.

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Tolomeo M, Magliocca V, Petrini S, Nisco A, Barbaro R, Lanza M, Piccione M, Giudetti AM, Massey K, Console L, Indiveri C, Zanier K, Bertini E, Persichini T, Compagnucci C, Colella M, Barile M. Altered dimerization of certain riboflavin transporter 2 mutants: a possible source of UPR, altered calcium signalling and mitochondrial derangements in RTD2. Arch Biochem Biophys. 2026 Jan; 775:110675.

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Yin X, Wang R, Thackeray A, Baehrecke EH, Alkema MJ. VPS13D mutations affect mitochondrial homeostasis and locomotion in Caenorhabditis elegans. G3 (Bethesda). 2025 04 17; 15(4).

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Pullen KM, Finethy R, Ko SB, Reames CJ, Sassetti CM, Lauffenburger DA. Cross-species transcriptomics translation reveals a role for the unfolded protein response in Mycobacterium tuberculosis infection. NPJ Syst Biol Appl. 2025 Feb 15; 11(1):19.

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Mallick A, Haynes CM. Methods to analyze the mitochondrial unfolded protein response (UPRmt). Methods Enzymol. 2024; 707:543-564.

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Kim S, Ramalho TR, Haynes CM. Regulation of proteostasis and innate immunity via mitochondria-nuclear communication. J Cell Biol. 2024 03 04; 223(3).

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Uma Naresh N, Kim S, Shpilka T, Yang Q, Du Y, Haynes CM. Mitochondrial genome recovery by ATFS-1 is essential for development after starvation. Cell Rep. 2022 12 27; 41(13):111875.

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Haynes CM, Hekimi S. Mitochondrial dysfunction, aging, and the mitochondrial unfolded protein response in Caenorhabditis elegans. Genetics. 2022 11 30; 222(4).

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Sharma RB, Landa-Galv?n HV, Alonso LC. Living Dangerously: Protective and Harmful ER Stress Responses in Pancreatic ?-Cells. Diabetes. 2021 11; 70(11):2431-2443.

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Charbord J, Ren L, Sharma RB, Johansson A, ?gren R, Chu L, Tworus D, Schulz N, Charbord P, Stewart AF, Wang P, Alonso LC, Andersson O. In vivo screen identifies a SIK inhibitor that induces ? cell proliferation through a transient UPR. Nat Metab. 2021 05; 3(5):682-700.

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