Protein Prenylation

"Protein Prenylation" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A post-translational modification of proteins by the attachment of an isoprenoid to the C-terminal cysteine residue. The isoprenoids used, farnesyl diphosphate or geranylgeranyl diphosphate, are derived from the same biochemical pathway that produces cholesterol.

Descriptor ID	D017368
MeSH Number(s)	G02.111.660.871.790.600.400 G02.111.672.500 G02.111.691.600.400 G03.734.871.790.600.400 G03.804.500 G05.308.670.600.400
Concept/Terms	Protein Prenylation Protein Prenylation Prenylation, Protein Protein Polyisoprenylation Protein Polyisoprenylation Polyisoprenylation, Protein Protein Isoprenylation Protein Isoprenylation Post-Translational Isoprenylation Protein Farnesylation Protein Farnesylation Farnesylation, Protein Protein Geranylgeranylation Protein Geranylgeranylation Geranylgeranylation, Protein

Below are MeSH descriptors whose meaning is more general than "Protein Prenylation".

Biological Sciences [G]
Chemical Phenomena [G02]
Biochemical Phenomena [G02.111]
Peptide Biosynthesis [G02.111.660]
Protein Biosynthesis [G02.111.660.871]
Protein Modification, Translational [G02.111.660.871.790]
Protein Processing, Post-Translational [G02.111.660.871.790.600]
Protein Prenylation [G02.111.660.871.790.600.400]
Prenylation [G02.111.672]
Protein Prenylation [G02.111.672.500]
Protein Modification, Translational [G02.111.691]
Protein Processing, Post-Translational [G02.111.691.600]
Protein Prenylation [G02.111.691.600.400]
Metabolism [G03]
Peptide Biosynthesis [G03.734]
Protein Biosynthesis [G03.734.871]
Protein Modification, Translational [G03.734.871.790]
Protein Processing, Post-Translational [G03.734.871.790.600]
Protein Prenylation [G03.734.871.790.600.400]
Prenylation [G03.804]
Protein Prenylation [G03.804.500]
Genetic Phenomena [G05]
Gene Expression Regulation [G05.308]
Protein Modification, Translational [G05.308.670]
Protein Processing, Post-Translational [G05.308.670.600]
Protein Prenylation [G05.308.670.600.400]

Below are MeSH descriptors whose meaning is related to "Protein Prenylation".

Below are MeSH descriptors whose meaning is more specific than "Protein Prenylation".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Protein Prenylation" by people in this website by year, and whether "Protein Prenylation" was a major or minor topic of these publications.

Bar chart showing 7 publications over 6 distinct years, with a maximum of 2 publications in 2010

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2002	0	1	1
2007	0	1	1
2010	1	1	2
2012	0	1	1
2019	1	0	1
2021	0	1	1

Below are the most recent publications written about "Protein Prenylation" by people in Profiles.

Wickenhagen A, Sugrue E, Lytras S, Kuchi S, Noerenberg M, Turnbull ML, Loney C, Herder V, Allan J, Jarmson I, Cameron-Ruiz N, Varjak M, Pinto RM, Lee JY, Iselin L, Palmalux N, Stewart DG, Swingler S, Greenwood EJD, Crozier TWM, Gu Q, Davies EL, Clohisey S, Wang B, Trindade Maranh?o Costa F, Freire Santana M, de Lima Ferreira LC, Murphy L, Fawkes A, Meynert A, Grimes G, Da Silva Filho JL, Marti M, Hughes J, Stanton RJ, Wang ECY, Ho A, Davis I, Jarrett RF, Castello A, Robertson DL, Semple MG, Openshaw PJM, Palmarini M, Lehner PJ, Baillie JK, Rihn SJ, Wilson SJ. A prenylated dsRNA sensor protects against severe COVID-19. Science. 2021 Oct 29; 374(6567):eabj3624.

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Yang S, Harding AT, Sweeney C, Miao D, Swan G, Zhou C, Jiang Z, Fitzgerald KA, Hammer G, Bergo MO, Kroh HK, Lacy DB, Sun C, Glogauer M, Que LG, Heaton NS, Wang D. Control of antiviral innate immune response by protein geranylgeranylation. Sci Adv. 2019 05; 5(5):eaav7999.

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Rao KN, Zhang W, Li L, Anand M, Khanna H. Prenylated retinal ciliopathy protein RPGR interacts with PDE6d and regulates ciliary localization of Joubert syndrome-associated protein INPP5E. Hum Mol Genet. 2016 10 15; 25(20):4533-4545.

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Albadawi H, Haurani MJ, Oklu R, Trubiano JP, Laub PJ, Yoo HJ, Watkins MT. Differential effect of zoledronic acid on human vascular smooth muscle cells. J Surg Res. 2013 Jun 15; 182(2):339-46.

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Moriceau G, Ory B, Mitrofan L, Riganti C, Blanchard F, Brion R, Charrier C, Battaglia S, Pilet P, Denis MG, Shultz LD, M?nkk?nen J, R?dini F, Heymann D. Zoledronic acid potentiates mTOR inhibition and abolishes the resistance of osteosarcoma cells to RAD001 (Everolimus): pivotal role of the prenylation process. Cancer Res. 2010 Dec 15; 70(24):10329-39.

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Balasubramanian S, Messmer-Blust AF, Jeyaratnam JA, Vestal DJ. Role of GTP binding, isoprenylation, and the C-terminal a-helices in the inhibition of cell spreading by the interferon-induced GTPase, mouse guanylate-binding protein-2. J Interferon Cytokine Res. 2011 Mar; 31(3):291-8.

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Seres I, F?ris G, Varga Z, Koszt?czky B, Kassai A, Balogh Z, F?l?p P, Paragh G. The association between angiotensin II-induced free radical generation and membrane fluidity in neutrophils of patients with metabolic syndrome. J Membr Biol. 2006; 214(2):91-8.

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Jang DS, Cuendet M, Hawthorne ME, Kardono LB, Kawanishi K, Fong HH, Mehta RG, Pezzuto JM, Kinghorn AD. Prenylated flavonoids of the leaves of Macaranga conifera with inhibitory activity against cyclooxygenase-2. Phytochemistry. 2002 Dec; 61(7):867-72.

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Yanachkov I, Pan JY, Wessling-Resnick M, Wright GE. Synthesis and effect of nonhydrolyzable xanthosine triphosphate derivatives on prenylation of Rab5D136N. Mol Pharmacol. 1997 Jan; 51(1):47-51.

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