"Transducin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A heterotrimeric GTP-binding protein that mediates the light activation signal from photolyzed rhodopsin to cyclic GMP phosphodiesterase and is pivotal in the visual excitation process. Activation of rhodopsin on the outer membrane of rod and cone cells causes GTP to bind to transducin followed by dissociation of the alpha subunit-GTP complex from the beta/gamma subunits of transducin. The alpha subunit-GTP complex activates the cyclic GMP phosphodiesterase which catalyzes the hydrolysis of cyclic GMP to 5'-GMP. This leads to closure of the sodium and calcium channels and therefore hyperpolarization of the rod cells.
| Descriptor ID |
D015293
|
| MeSH Number(s) |
D08.811.277.040.330.300.200.800 D12.644.360.360.940 D12.776.157.325.332.940 D12.776.476.375.940 D12.776.543.325.800
|
| Concept/Terms |
Transducin- Transducin
- Transducin G-Protein (Gt)
- Gt, Transducin G-Protein
- G-Protein Gt, Transducin
- Gt, Transducin G Protein
- Transducin G-Protein Gt
- G-Protein, Inhibitory Gt
- G Protein, Inhibitory Gt
- Gt G-Protein, Inhibitory
- Inhibitory Gt G-Protein
gamma-Transducin- gamma-Transducin
- gamma Transducin
- Transducin, gamma Subunit
- gamma Subunit Transducin
beta-Transducin- beta-Transducin
- beta Transducin
- Transducin, beta Subunit
- beta Subunit Transducin
alpha-Transducin- alpha-Transducin
- alpha Transducin
- Transducin, alpha Subunit
- alpha Subunit Transducin
|
Below are MeSH descriptors whose meaning is more general than "Transducin".
Below are MeSH descriptors whose meaning is more specific than "Transducin".
This graph shows the total number of publications written about "Transducin" by people in this website by year, and whether "Transducin" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 1 | 0 | 1 |
| 2017 | 0 | 1 | 1 |
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Below are the most recent publications written about "Transducin" by people in Profiles.
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Zheng K, Lu P, Delpapa E, Bellve K, Deng R, Condon JC, Fogarty K, Lifshitz LM, Simas TAM, Shi F, ZhuGe R. Bitter taste receptors as targets for tocolytics in preterm labor therapy. FASEB J. 2017 09; 31(9):4037-4052.
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Li TF, Chen D, Wu Q, Chen M, Sheu TJ, Schwarz EM, Drissi H, Zuscik M, O'Keefe RJ. Transforming growth factor-beta stimulates cyclin D1 expression through activation of beta-catenin signaling in chondrocytes. J Biol Chem. 2006 Jul 28; 281(30):21296-21304.
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Nishiguchi KM, Sandberg MA, Gorji N, Berson EL, Dryja TP. Cone cGMP-gated channel mutations and clinical findings in patients with achromatopsia, macular degeneration, and other hereditary cone diseases. Hum Mutat. 2005 Mar; 25(3):248-58.
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Cheng H, Khanna H, Oh EC, Hicks D, Mitton KP, Swaroop A. Photoreceptor-specific nuclear receptor NR2E3 functions as a transcriptional activator in rod photoreceptors. Hum Mol Genet. 2004 Aug 01; 13(15):1563-75.
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Struthers M, Yu H, Kono M, Oprian DD. Tertiary interactions between the fifth and sixth transmembrane segments of rhodopsin. Biochemistry. 1999 May 18; 38(20):6597-603.
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Kono M, Yu H, Oprian DD. Disulfide bond exchange in rhodopsin. Biochemistry. 1998 Feb 03; 37(5):1302-5.
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Sondek J, Bohm A, Lambright DG, Hamm HE, Sigler PB. Crystal structure of a G-protein beta gamma dimer at 2.1A resolution. Nature. 1996 Jan 25; 379(6563):369-74.
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Yu H, Kono M, McKee TD, Oprian DD. A general method for mapping tertiary contacts between amino acid residues in membrane-embedded proteins. Biochemistry. 1995 Nov 21; 34(46):14963-9.
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Sondek J, Lambright DG, Noel JP, Hamm HE, Sigler PB. GTPase mechanism of Gproteins from the 1.7-A crystal structure of transducin alpha-GDP-AIF-4. Nature. 1994 Nov 17; 372(6503):276-9.
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Lambright DG, Noel JP, Hamm HE, Sigler PB. Structural determinants for activation of the alpha-subunit of a heterotrimeric G protein. Nature. 1994 Jun 23; 369(6482):621-8.