Transcription Factor CHOP

"Transcription Factor CHOP" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A CCAAT-enhancer binding protein that is induced by DNA DAMAGE and growth arrest. It serves as a dominant negative inhibitor of other CCAAT-enhancer binding proteins.

Descriptor ID	D051742
MeSH Number(s)	D12.776.260.108.124.875 D12.776.660.167.875 D12.776.930.127.124.875
Concept/Terms	Transcription Factor CHOP Transcription Factor CHOP CHOP, Transcription Factor Growth Arrest And DNA Damage-Inducible Protein 153 Growth Arrest And DNA Damage Inducible Protein 153 DNA Damage-Inducible Transcript 3 Protein DNA Damage Inducible Transcript 3 Protein GADD153 Protein C-EBP Homologous Protein C EBP Homologous Protein Homologous Protein, C-EBP DDIT3 Protein

Below are MeSH descriptors whose meaning is more general than "Transcription Factor CHOP".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
DNA-Binding Proteins [D12.776.260]
Basic-Leucine Zipper Transcription Factors [D12.776.260.108]
CCAAT-Enhancer-Binding Proteins [D12.776.260.108.124]
Transcription Factor CHOP [D12.776.260.108.124.875]
Nuclear Proteins [D12.776.660]
CCAAT-Enhancer-Binding Proteins [D12.776.660.167]
Transcription Factor CHOP [D12.776.660.167.875]
Transcription Factors [D12.776.930]
Basic-Leucine Zipper Transcription Factors [D12.776.930.127]
CCAAT-Enhancer-Binding Proteins [D12.776.930.127.124]
Transcription Factor CHOP [D12.776.930.127.124.875]

Below are MeSH descriptors whose meaning is related to "Transcription Factor CHOP".

Below are MeSH descriptors whose meaning is more specific than "Transcription Factor CHOP".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Transcription Factor CHOP" by people in this website by year, and whether "Transcription Factor CHOP" was a major or minor topic of these publications.

Bar chart showing 6 publications over 5 distinct years, with a maximum of 2 publications in 2009

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2009	2	0	2
2014	1	0	1
2016	1	0	1
2018	0	1	1
2025	0	1	1

Below are the most recent publications written about "Transcription Factor CHOP" by people in Profiles.

Cai Y, Wang X, Xiang Y, Wang Z, Long Q, Zeng C. Codonopsis pilosula polysaccharides alleviate neuronal apoptosis induced by endoplasmic reticulum stress-activated PERK-ATF4-CHOP signaling in APP/PS1 mice. J Alzheimers Dis. 2025 Jul; 106(1):317-330.

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Huiting LN, Samaha Y, Zhang GL, Roderick JE, Li B, Anderson NM, Wang YW, Wang L, Laroche F, Choi JW, Liu CT, Kelliher MA, Feng H. UFD1 contributes to MYC-mediated leukemia aggressiveness through suppression of the proapoptotic unfolded protein response. Leukemia. 2018 11; 32(11):2339-2351.

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Valderrama C, Clark A, Urano F, Unanue ER, Carrero JA. Listeria monocytogenes induces an interferon-enhanced activation of the integrated stress response that is detrimental for resolution of infection in mice. Eur J Immunol. 2017 05; 47(5):830-840.

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Ayaub EA, Kolb PS, Mohammed-Ali Z, Tat V, Murphy J, Bellaye PS, Shimbori C, Boivin FJ, Lai R, Lynn EG, Lhot?k ?, Bridgewater D, Kolb MR, Inman MD, Dickhout JG, Austin RC, Ask K. GRP78 and CHOP modulate macrophage apoptosis and the development of bleomycin-induced pulmonary fibrosis. J Pathol. 2016 08; 239(4):411-25.

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Vomund AN, Zinselmeyer BH, Hughes J, Calderon B, Valderrama C, Ferris ST, Wan X, Kanekura K, Carrero JA, Urano F, Unanue ER. Beta cells transfer vesicles containing insulin to phagocytes for presentation to T cells. Proc Natl Acad Sci U S A. 2015 Oct 06; 112(40):E5496-502.

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Dong B, Zhou H, Han C, Yao J, Xu L, Zhang M, Fu Y, Xia Q. Ischemia/reperfusion-induced CHOP expression promotes apoptosis and impairs renal function recovery: the role of acidosis and GPR4. PLoS One. 2014; 9(10):e110944.

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Yang C, Diiorio P, Jurczyk A, O'Sullivan-Murphy B, Urano F, Bortell R. Pathological endoplasmic reticulum stress mediated by the IRE1 pathway contributes to pre-insulitic beta cell apoptosis in a virus-induced rat model of type 1 diabetes. Diabetologia. 2013 Dec; 56(12):2638-46.

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Woo CW, Cui D, Arellano J, Dorweiler B, Harding H, Fitzgerald KA, Ron D, Tabas I. Adaptive suppression of the ATF4-CHOP branch of the unfolded protein response by toll-like receptor signalling. Nat Cell Biol. 2009 Dec; 11(12):1473-80.

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Pino SC, O'Sullivan-Murphy B, Lidstone EA, Yang C, Lipson KL, Jurczyk A, diIorio P, Brehm MA, Mordes JP, Greiner DL, Rossini AA, Bortell R. CHOP mediates endoplasmic reticulum stress-induced apoptosis in Gimap5-deficient T cells. PLoS One. 2009; 4(5):e5468.

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Kubota K, Lee DH, Tsuchiya M, Young CS, Everett ET, Martinez-Mier EA, Snead ML, Nguyen L, Urano F, Bartlett JD. Fluoride induces endoplasmic reticulum stress in ameloblasts responsible for dental enamel formation. J Biol Chem. 2005 Jun 17; 280(24):23194-202.

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