Sterol Regulatory Element Binding Protein 2

"Sterol Regulatory Element Binding Protein 2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A sterol regulatory element binding protein that regulates GENES involved in CHOLESTEROL synthesis and uptake.

Descriptor ID	D051782
MeSH Number(s)	D12.776.260.103.500.750.750 D12.776.260.108.092.750.750 D12.776.930.125.500.750.750 D12.776.930.127.092.750.750
Concept/Terms	Sterol Regulatory Element Binding Protein 2 Sterol Regulatory Element Binding Protein 2 SREBP2 Protein Sterol-Regulatory Element-Binding Protein 2 SRE-2 Binding Protein SRE 2 Binding Protein

Below are MeSH descriptors whose meaning is more general than "Sterol Regulatory Element Binding Protein 2".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
DNA-Binding Proteins [D12.776.260]
Basic Helix-Loop-Helix Transcription Factors [D12.776.260.103]
Basic Helix-Loop-Helix Leucine Zipper Transcription Factors [D12.776.260.103.500]
Sterol Regulatory Element Binding Proteins [D12.776.260.103.500.750]
Sterol Regulatory Element Binding Protein 2 [D12.776.260.103.500.750.750]
Basic-Leucine Zipper Transcription Factors [D12.776.260.108]
Basic Helix-Loop-Helix Leucine Zipper Transcription Factors [D12.776.260.108.092]
Sterol Regulatory Element Binding Proteins [D12.776.260.108.092.750]
Sterol Regulatory Element Binding Protein 2 [D12.776.260.108.092.750.750]
Transcription Factors [D12.776.930]
Basic Helix-Loop-Helix Transcription Factors [D12.776.930.125]
Basic Helix-Loop-Helix Leucine Zipper Transcription Factors [D12.776.930.125.500]
Sterol Regulatory Element Binding Proteins [D12.776.930.125.500.750]
Sterol Regulatory Element Binding Protein 2 [D12.776.930.125.500.750.750]
Basic-Leucine Zipper Transcription Factors [D12.776.930.127]
Basic Helix-Loop-Helix Leucine Zipper Transcription Factors [D12.776.930.127.092]
Sterol Regulatory Element Binding Proteins [D12.776.930.127.092.750]
Sterol Regulatory Element Binding Protein 2 [D12.776.930.127.092.750.750]

Below are MeSH descriptors whose meaning is related to "Sterol Regulatory Element Binding Protein 2".

Below are MeSH descriptors whose meaning is more specific than "Sterol Regulatory Element Binding Protein 2".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Sterol Regulatory Element Binding Protein 2" by people in this website by year, and whether "Sterol Regulatory Element Binding Protein 2" was a major or minor topic of these publications.

Bar chart showing 5 publications over 5 distinct years, with a maximum of 1 publications in 2004 and 2010 and 2011 and 2018 and 2021

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2004	0	1	1
2010	1	0	1
2011	1	0	1
2018	0	1	1
2021	1	0	1

Below are the most recent publications written about "Sterol Regulatory Element Binding Protein 2" by people in Profiles.

Trindade BC, Ceglia S, Berthelette A, Raso F, Howley K, Muppidi JR, Reboldi A. The cholesterol metabolite 25-hydroxycholesterol restrains the transcriptional regulator SREBP2 and limits intestinal IgA plasma cell differentiation. Immunity. 2021 10 12; 54(10):2273-2287.e6.

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Moon SH, Huang CH, Houlihan SL, Regunath K, Freed-Pastor WA, Morris JP, Tschaharganeh DF, Kastenhuber ER, Barsotti AM, Culp-Hill R, Xue W, Ho YJ, Baslan T, Li X, Mayle A, de Stanchina E, Zender L, Tong DR, D'Alessandro A, Lowe SW, Prives C. p53 Represses the Mevalonate Pathway to Mediate Tumor Suppression. Cell. 2019 01 24; 176(3):564-580.e19.

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Tsoi H, Chu ESH, Zhang X, Sheng J, Nakatsu G, Ng SC, Chan AWH, Chan FKL, Sung JJY, Yu J. Peptostreptococcus anaerobius Induces Intracellular Cholesterol Biosynthesis in Colon Cells to Induce Proliferation and Causes Dysplasia in Mice. Gastroenterology. 2017 05; 152(6):1419-1433.e5.

View in: PubMed
Peterson TR, Sengupta SS, Harris TE, Carmack AE, Kang SA, Balderas E, Guertin DA, Madden KL, Carpenter AE, Finck BN, Sabatini DM. mTOR complex 1 regulates lipin 1 localization to control the SREBP pathway. Cell. 2011 Aug 05; 146(3):408-20.

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Walker AK, Yang F, Jiang K, Ji JY, Watts JL, Purushotham A, Boss O, Hirsch ML, Ribich S, Smith JJ, Israelian K, Westphal CH, Rodgers JT, Shioda T, Elson SL, Mulligan P, Najafi-Shoushtari H, Black JC, Thakur JK, Kadyk LC, Whetstine JR, Mostoslavsky R, Puigserver P, Li X, Dyson NJ, Hart AC, N??r AM. Conserved role of SIRT1 orthologs in fasting-dependent inhibition of the lipid/cholesterol regulator SREBP. Genes Dev. 2010 Jul 01; 24(13):1403-17.

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Wang H, Sartini BL, Millette CF, Kilpatrick DL. A developmental switch in transcription factor isoforms during spermatogenesis controlled by alternative messenger RNA 3'-end formation. Biol Reprod. 2006 Sep; 75(3):318-23.

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Wang H, San Agustin JT, Witman GB, Kilpatrick DL. Novel role for a sterol response element binding protein in directing spermatogenic cell-specific gene expression. Mol Cell Biol. 2004 Dec; 24(24):10681-8.

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