B7-1 Antigen

"B7-1 Antigen" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A costimulatory ligand membrane glycoprotein that contains a V2 type and C2 IMMUNOGLOBULIN DOMAIN and is expressed by ANTIGEN-PRESENTING CELLS. It binds to CTLA-4 ANTIGEN with high specificity and to CD28 ANTIGEN with low specificity. The interaction of CD80 with CD28 ANTIGEN provides a costimulatory signal to T-LYMPHOCYTES, while its interaction with CTLA-4 ANTIGEN may play a role in inducing PERIPHERAL TOLERANCE.

Descriptor ID	D018122
MeSH Number(s)	D12.776.467.150.100 D12.776.543.095.100 D23.050.301.285.100 D23.529.168.100
Concept/Terms	B7-1 Antigen B7-1 Antigen B7 1 Antigen CD80 Antigen CD80 Antigens B7-1 Ligand B7 1 Ligand Ligand, B7-1 B7-1 Costimulatory Molecule B7 1 Costimulatory Molecule Costimulatory Molecule, B7-1 Antigen, B7-1 Antigen, B7 1 B-Cell Activation Antigen B Cell Activation Antigen Antigens, CD80

Below are MeSH descriptors whose meaning is more general than "B7-1 Antigen".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Intercellular Signaling Peptides and Proteins [D12.776.467]
B7 Antigens [D12.776.467.150]
B7-1 Antigen [D12.776.467.150.100]
Membrane Proteins [D12.776.543]
B7 Antigens [D12.776.543.095]
B7-1 Antigen [D12.776.543.095.100]
Biological Factors [D23]
Antigens [D23.050]
Antigens, Surface [D23.050.301]
B7 Antigens [D23.050.301.285]
B7-1 Antigen [D23.050.301.285.100]
Intercellular Signaling Peptides and Proteins [D23.529]
B7 Antigens [D23.529.168]
B7-1 Antigen [D23.529.168.100]

Below are MeSH descriptors whose meaning is related to "B7-1 Antigen".

Below are MeSH descriptors whose meaning is more specific than "B7-1 Antigen".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "B7-1 Antigen" by people in this website by year, and whether "B7-1 Antigen" was a major or minor topic of these publications.

Bar chart showing 62 publications over 18 distinct years, with a maximum of 8 publications in 1997

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1995	4	2	6
1996	1	2	3
1997	8	0	8
1998	3	3	6
1999	0	2	2
2000	1	5	6
2001	4	2	6
2002	1	3	4
2003	3	2	5
2004	1	2	3
2005	0	1	1
2006	0	1	1
2007	1	0	1
2009	3	1	4
2011	3	0	3
2012	0	1	1
2014	0	1	1
2015	0	1	1

Below are the most recent publications written about "B7-1 Antigen" by people in Profiles.

Wongchana W, Lawlor RG, Osborne BA, Palaga T. Impact of Notch1 Deletion in Macrophages on Proinflammatory Cytokine Production and the Outcome of Experimental Autoimmune Encephalomyelitis. J Immunol. 2015 Dec 01; 195(11):5337-46.

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Fuchs YF, Adler K, Lindner A, Karasinsky A, Wilhelm C, Weigelt M, Balke H, F?rtsch K, Mortler-Hildebrandt LF, Harlan DM, Pechhold K, Ziegler AG, Bonifacio E. IGRP and insulin vaccination induce CD8+ T cell-mediated autoimmune diabetes in the RIP-CD80GP mouse. Clin Exp Immunol. 2014 May; 176(2):199-206.

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Riella LV, Liu T, Yang J, Chock S, Shimizu T, Mfarrej B, Batal I, Xiao X, Sayegh MH, Chandraker A. Deleterious effect of CTLA4-Ig on a Treg-dependent transplant model. Am J Transplant. 2012 Apr; 12(4):846-55.

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Yang J, Riella LV, Chock S, Liu T, Zhao X, Yuan X, Paterson AM, Watanabe T, Vanguri V, Yagita H, Azuma M, Blazar BR, Freeman GJ, Rodig SJ, Sharpe AH, Chandraker A, Sayegh MH. The novel costimulatory programmed death ligand 1/B7.1 pathway is functional in inhibiting alloimmune responses in vivo. J Immunol. 2011 Aug 01; 187(3):1113-9.

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Paterson AM, Brown KE, Keir ME, Vanguri VK, Riella LV, Chandraker A, Sayegh MH, Blazar BR, Freeman GJ, Sharpe AH. The programmed death-1 ligand 1:B7-1 pathway restrains diabetogenic effector T cells in vivo. J Immunol. 2011 Aug 01; 187(3):1097-105.

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Riella LV, Watanabe T, Sage PT, Yang J, Yeung M, Azzi J, Vanguri V, Chandraker A, Sharpe AH, Sayegh MH, Najafian N. Essential role of PDL1 expression on nonhematopoietic donor cells in acquired tolerance to vascularized cardiac allografts. Am J Transplant. 2011 Apr; 11(4):832-40.

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Francisco LM, Salinas VH, Brown KE, Vanguri VK, Freeman GJ, Kuchroo VK, Sharpe AH. PD-L1 regulates the development, maintenance, and function of induced regulatory T cells. J Exp Med. 2009 Dec 21; 206(13):3015-29.

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Driver JP, Scheuplein F, Chen YG, Grier AE, Wilson SB, Serreze DV. Invariant natural killer T-cell control of type 1 diabetes: a dendritic cell genetic decision of a silver bullet or Russian roulette. Diabetes. 2010 Feb; 59(2):423-32.

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Yang J, Riella LV, Boenisch O, Popoola J, Robles S, Watanabe T, Vanguri V, Yuan X, Guleria I, Turka LA, Sayegh MH, Chandraker A. Paradoxical functions of B7: CD28 costimulation in a MHC class II-mismatched cardiac transplant model. Am J Transplant. 2009 Dec; 9(12):2837-44.

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Paterson AM, Vanguri VK, Sharpe AH. SnapShot: B7/CD28 costimulation. Cell. 2009 May 29; 137(5):974-4.e1.

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