B7-2 Antigen

"B7-2 Antigen" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A costimulatory ligand glycoprotein that contains a C2 and V-type IMMUNOGLOBULIN DOMAIN. It is expressed by ANTIGEN-PRESENTING CELLS and binds to CD28 ANTIGEN with high specificity and to CTLA-4 ANTIGEN with low specificity. The interaction of CD86 with CD28 ANTIGEN provides a stimulatory signal to T-LYMPHOCYTES, while its interaction with CTLA-4 ANTIGEN may play a role in inducing PERIPHERAL TOLERANCE.

Descriptor ID	D051940
MeSH Number(s)	D12.776.467.150.200 D12.776.543.095.200 D23.050.301.285.200 D23.529.168.200
Concept/Terms	B7-2 Antigen B7-2 Antigen B7 2 Antigen B7-2 Costimulatory Molecule Costimulatory Molecule, B7-2 B70 Costimulatory Molecule Costimulatory Molecule, B70 Early T Cell Costimulatory Molecule 1 CD86 Antigens Antigen, B7-2 Antigen, B7 2 Antigens, CD86 CD86 Antigen Antigen, CD86

Below are MeSH descriptors whose meaning is more general than "B7-2 Antigen".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Intercellular Signaling Peptides and Proteins [D12.776.467]
B7 Antigens [D12.776.467.150]
B7-2 Antigen [D12.776.467.150.200]
Membrane Proteins [D12.776.543]
B7 Antigens [D12.776.543.095]
B7-2 Antigen [D12.776.543.095.200]
Biological Factors [D23]
Antigens [D23.050]
Antigens, Surface [D23.050.301]
B7 Antigens [D23.050.301.285]
B7-2 Antigen [D23.050.301.285.200]
Intercellular Signaling Peptides and Proteins [D23.529]
B7 Antigens [D23.529.168]
B7-2 Antigen [D23.529.168.200]

Below are MeSH descriptors whose meaning is related to "B7-2 Antigen".

Below are MeSH descriptors whose meaning is more specific than "B7-2 Antigen".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "B7-2 Antigen" by people in this website by year, and whether "B7-2 Antigen" was a major or minor topic of these publications.

Bar chart showing 26 publications over 11 distinct years, with a maximum of 4 publications in 1998 and 2002

To see the data from this visualization as text, click here.

Year	Minor Topic	Total
1995	1	1
1997	3	3
1998	4	4
1999	1	1
2000	3	3
2001	3	3
2002	4	4
2003	1	1
2004	3	3
2005	1	1
2006	2	2

Below are the most recent publications written about "B7-2 Antigen" by people in Profiles.

Wang Q, McLoughlin RM, Cobb BA, Charrel-Dennis M, Zaleski KJ, Golenbock D, Tzianabos AO, Kasper DL. A bacterial carbohydrate links innate and adaptive responses through Toll-like receptor 2. J Exp Med. 2006 Dec 25; 203(13):2853-63.

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Colonna L, Dinnall JA, Shivers DK, Frisoni L, Caricchio R, Gallucci S. Abnormal costimulatory phenotype and function of dendritic cells before and after the onset of severe murine lupus. Arthritis Res Ther. 2006; 8(2):R49.

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Kandimalla ER, Bhagat L, Li Y, Yu D, Wang D, Cong YP, Song SS, Tang JX, Sullivan T, Agrawal S. Immunomodulatory oligonucleotides containing a cytosine-phosphate-2'-deoxy-7-deazaguanosine motif as potent toll-like receptor 9 agonists. Proc Natl Acad Sci U S A. 2005 May 10; 102(19):6925-30.

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Vivarelli MS, McDonald D, Miller M, Cusson N, Kelliher M, Geha RS. RIP links TLR4 to Akt and is essential for cell survival in response to LPS stimulation. J Exp Med. 2004 Aug 02; 200(3):399-404.

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Imitola J, Comabella M, Chandraker AK, Dangond F, Sayegh MH, Snyder EY, Khoury SJ. Neural stem/progenitor cells express costimulatory molecules that are differentially regulated by inflammatory and apoptotic stimuli. Am J Pathol. 2004 May; 164(5):1615-25.

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Zhu X, Coleman RA, Alber C, Ballas ZK, Waldschmidt TJ, Ray NB, Krieg AM, Cook RT. Chronic ethanol ingestion by mice increases expression of CD80 and CD86 by activated macrophages. Alcohol. 2004 Feb; 32(2):91-100.

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Pearson T, Markees TG, Serreze DV, Pierce MA, Marron MP, Wicker LS, Peterson LB, Shultz LD, Mordes JP, Rossini AA, Greiner DL. Genetic disassociation of autoimmunity and resistance to costimulation blockade-induced transplantation tolerance in nonobese diabetic mice. J Immunol. 2003 Jul 01; 171(1):185-95.

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Liu Z, Liu Q, Pesce J, Whitmire J, Ekkens MJ, Foster A, VanNoy J, Sharpe AH, Urban JF, Gause WC. Nippostrongylus brasiliensis can induce B7-independent antigen-specific development of IL-4-producing T cells from naive CD4 T cells in vivo. J Immunol. 2002 Dec 15; 169(12):6959-68.

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Montgomery SP, Xu H, Tadaki DK, Celniker A, Burkly LC, Berning JD, Cruzata F, Elster EA, Gray G, Kampen RL, Swanson SJ, Harlan DM, Kirk AD. Combination induction therapy with monoclonal antibodies specific for CD80, CD86, and CD154 in nonhuman primate renal transplantation. Transplantation. 2002 Nov 27; 74(10):1365-9.

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Yen MH, Lepak N, Swain SL. Induction of CD4 T cell changes in murine AIDS is dependent on costimulation and involves a dysregulation of homeostasis. J Immunol. 2002 Jul 15; 169(2):722-31.

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