Ribonucleoprotein, U2 Small Nuclear
"Ribonucleoprotein, U2 Small Nuclear" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A nuclear RNA-protein complex that plays a role in RNA processing. In the nucleoplasm, the U2 snRNP along with other small nuclear ribonucleoproteins (U1, U4-U6, and U5) assemble into SPLICEOSOMES that remove introns from pre-mRNA by splicing. The U2 snRNA forms base pairs with conserved sequence motifs at the branch point, which associates with a heat- and RNAase-sensitive factor in an early step of splicing.
| Descriptor ID |
D017413
|
| MeSH Number(s) |
D12.776.157.725.500.875.605 D12.776.157.725.829.344 D12.776.664.962.500.875.605 D12.776.664.962.829.344
|
| Concept/Terms |
Ribonucleoprotein, U2 Small Nuclear- Ribonucleoprotein, U2 Small Nuclear
- U2 Small Nuclear Ribonucleoproteins
- Ribonucleoproteins, Small, U2
- Small Nuclear Ribonucleoproteins, U2
- U2 snRNP
|
Below are MeSH descriptors whose meaning is more general than "Ribonucleoprotein, U2 Small Nuclear".
Below are MeSH descriptors whose meaning is more specific than "Ribonucleoprotein, U2 Small Nuclear".
This graph shows the total number of publications written about "Ribonucleoprotein, U2 Small Nuclear" by people in this website by year, and whether "Ribonucleoprotein, U2 Small Nuclear" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2004 | 0 | 1 | 1 |
| 2011 | 0 | 1 | 1 |
| 2012 | 1 | 0 | 1 |
| 2017 | 0 | 1 | 1 |
To return to the timeline,
click here.
Below are the most recent publications written about "Ribonucleoprotein, U2 Small Nuclear" by people in Profiles.
-
Yin S, Lopez-Gonzalez R, Kunz RC, Gangopadhyay J, Borufka C, Gygi SP, Gao FB, Reed R. Evidence that C9ORF72 Dipeptide Repeat Proteins Associate with U2 snRNP to Cause Mis-splicing in ALS/FTD Patients. Cell Rep. 2017 06 13; 19(11):2244-2256.
-
Loerch S, Maucuer A, Manceau V, Green MR, Kielkopf CL. Cancer-relevant splicing factor CAPERa engages the essential splicing factor SF3b155 in a specific ternary complex. J Biol Chem. 2014 Jun 20; 289(25):17325-37.
-
Maserati M, Dai X, Walentuk M, Mager J. Identification of four genes required for mammalian blastocyst formation. Zygote. 2014 Aug; 22(3):331-9.
-
Hoskins AA, Friedman LJ, Gallagher SS, Crawford DJ, Anderson EG, Wombacher R, Ramirez N, Cornish VW, Gelles J, Moore MJ. Ordered and dynamic assembly of single spliceosomes. Science. 2011 Mar 11; 331(6022):1289-95.
-
Jurica MS, Sousa D, Moore MJ, Grigorieff N. Three-dimensional structure of C complex spliceosomes by electron microscopy. Nat Struct Mol Biol. 2004 Mar; 11(3):265-9.
-
Kan JL, Green MR. Pre-mRNA splicing of IgM exons M1 and M2 is directed by a juxtaposed splicing enhancer and inhibitor. Genes Dev. 1999 Feb 15; 13(4):462-71.
-
Fleckner J, Zhang M, Valc?rcel J, Green MR. U2AF65 recruits a novel human DEAD box protein required for the U2 snRNP-branchpoint interaction. Genes Dev. 1997 Jul 15; 11(14):1864-72.