Codon, Terminator

"Codon, Terminator" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Any codon that signals the termination of genetic translation (TRANSLATION, GENETIC). PEPTIDE TERMINATION FACTORS bind to the stop codon and trigger the hydrolysis of the aminoacyl bond connecting the completed polypeptide to the tRNA. Terminator codons do not specify amino acids.

Descriptor ID	D018388
MeSH Number(s)	D13.444.735.544.355.250 G05.360.335.355.250 G05.360.340.024.340.137.190.250
Concept/Terms	Codon, Terminator Codon, Terminator Codons, Terminator Terminator Codons Codon, Termination Codons, Termination Termination Codon Termination Codons Stop Codon Codon, Stop Codons, Stop Stop Codons Terminator Codon Stop Signal, Translation Stop Signals, Translation Translation Stop Signal Translation Stop Signals Ochre Stop Codon Ochre Stop Codon Codons, Ochre Stop Ochre Stop Codons Stop Codon, Ochre Stop Codons, Ochre Stop Codon UAA Codon UAA, Stop UAA, Stop Codon Ochre Codon Codon, Ochre Codons, Ochre Ochre Codons UAA Codon Codon, UAA Codons, UAA UAA Codons Codon, Ochre Stop UAA Stop Codon Codon, UAA Stop Codons, UAA Stop Stop Codon, UAA Stop Codons, UAA UAA Stop Codons TAA Codon Codon, TAA Codons, TAA TAA Codons Opal Stop Codon Opal Stop Codon Codons, Opal Stop Opal Stop Codons Stop Codon, Opal Stop Codons, Opal Stop Codon UGA Codon UGA, Stop Stop Codon UGAs UGA, Stop Codon Opal Codon Codon, Opal Codons, Opal Opal Codons UGA Codon Codon, UGA Codons, UGA UGA Codons Codon, Opal Stop UGA Stop Codon Codon, UGA Stop Codons, UGA Stop Stop Codon, UGA Stop Codons, UGA UGA Stop Codons TGA Codon Codon, TGA Codons, TGA TGA Codons Amber Stop Codon Amber Stop Codon Amber Stop Codons Codons, Amber Stop Stop Codon, Amber Stop Codons, Amber Stop Codon UAG Codon UAG, Stop UAG, Stop Codon Amber Codon Amber Codons Codon, Amber Codons, Amber TAG Codon Codon, TAG Codons, TAG TAG Codons UAG Codon Codon, UAG Codons, UAG UAG Codons Codon, Amber Stop UAG Stop Codon Codon, UAG Stop Codons, UAG Stop Stop Codon, UAG Stop Codons, UAG UAG Stop Codons Amber Terminator Codon Amber Terminator Codons Codon, Amber Terminator Codons, Amber Terminator Terminator Codon, Amber Terminator Codons, Amber

Below are MeSH descriptors whose meaning is more general than "Codon, Terminator".

Chemicals and Drugs [D]
Nucleic Acids, Nucleotides, and Nucleosides [D13]
Nucleic Acids [D13.444]
RNA [D13.444.735]
RNA, Messenger [D13.444.735.544]
Codon [D13.444.735.544.355]
Codon, Terminator [D13.444.735.544.355.250]
Biological Sciences [G]
Genetic Phenomena [G05]
Genetic Structures [G05.360]
Genetic Code [G05.360.335]
Codon [G05.360.335.355]
Codon, Terminator [G05.360.335.355.250]
Genome [G05.360.340]
Genome Components [G05.360.340.024]
Genes [G05.360.340.024.340]
Gene Components [G05.360.340.024.340.137]
Codon [G05.360.340.024.340.137.190]
Codon, Terminator [G05.360.340.024.340.137.190.250]

Below are MeSH descriptors whose meaning is related to "Codon, Terminator".

Below are MeSH descriptors whose meaning is more specific than "Codon, Terminator".

Codon, Terminator
Codon, Nonsense

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Codon, Terminator" by people in this website by year, and whether "Codon, Terminator" was a major or minor topic of these publications.

Bar chart showing 17 publications over 13 distinct years, with a maximum of 3 publications in 2018

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1998	0	1	1
1999	0	1	1
2004	0	1	1
2008	0	2	2
2009	1	0	1
2010	1	0	1
2011	0	2	2
2016	1	0	1
2018	1	2	3
2020	0	1	1
2021	1	0	1
2022	0	1	1
2024	0	1	1

Below are the most recent publications written about "Codon, Terminator" by people in Profiles.

Mangkalaphiban K, Fu L, Du M, Thrasher K, Keeling KM, Bedwell DM, Jacobson A. Extended stop codon context predicts nonsense codon readthrough efficiency in human cells. Nat Commun. 2024 Mar 20; 15(1):2486.

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Wang J, Zhang Y, Mendonca CA, Yukselen O, Muneeruddin K, Ren L, Liang J, Zhou C, Xie J, Li J, Jiang Z, Kucukural A, Shaffer SA, Gao G, Wang D. AAV-delivered suppressor tRNA overcomes a nonsense mutation in mice. Nature. 2022 04; 604(7905):343-348.

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Mangkalaphiban K, He F, Ganesan R, Wu C, Baker R, Jacobson A. Transcriptome-wide investigation of stop codon readthrough in Saccharomyces cerevisiae. PLoS Genet. 2021 04; 17(4):e1009538.

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Wu C, Roy B, He F, Yan K, Jacobson A. Poly(A)-Binding Protein Regulates the Efficiency of Translation Termination. Cell Rep. 2020 11 17; 33(7):108399.

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Svidritskiy E, Demo G, Korostelev AA. Mechanism of premature translation termination on a sense codon. J Biol Chem. 2018 08 10; 293(32):12472-12479.

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Svidritskiy E, Korostelev AA. Conformational Control of Translation Termination on the 70S Ribosome. Structure. 2018 06 05; 26(6):821-828.e3.

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Svidritskiy E, Korostelev AA. Mechanism of Inhibition of Translation Termination by Blasticidin S. J Mol Biol. 2018 03 02; 430(5):591-593.

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Svidritskiy E, Madireddy R, Korostelev AA. Structural Basis for Translation Termination on a Pseudouridylated Stop Codon. J Mol Biol. 2016 05 22; 428(10 Pt B):2228-36.

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Schleifman EB, Bindra R, Leif J, del Campo J, Rogers FA, Uchil P, Kutsch O, Shultz LD, Kumar P, Greiner DL, Glazer PM. Targeted disruption of the CCR5 gene in human hematopoietic stem cells stimulated by peptide nucleic acids. Chem Biol. 2011 Sep 23; 18(9):1189-98.

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Korostelev AA. Structural aspects of translation termination on the ribosome. RNA. 2011 Aug; 17(8):1409-21.

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