"Pepsin A" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Formed from pig pepsinogen by cleavage of one peptide bond. The enzyme is a single polypeptide chain and is inhibited by methyl 2-diaazoacetamidohexanoate. It cleaves peptides preferentially at the carbonyl linkages of phenylalanine or leucine and acts as the principal digestive enzyme of gastric juice.
| Descriptor ID |
D010434
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| MeSH Number(s) |
D08.811.277.656.074.500.700 D08.811.277.656.300.048.700
|
| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Pepsin A".
Below are MeSH descriptors whose meaning is more specific than "Pepsin A".
This graph shows the total number of publications written about "Pepsin A" by people in this website by year, and whether "Pepsin A" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 1 | 1 |
| 2007 | 0 | 1 | 1 |
| 2008 | 0 | 1 | 1 |
| 2012 | 0 | 1 | 1 |
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Below are the most recent publications written about "Pepsin A" by people in Profiles.
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Bobst CE, Wang S, Shen WC, Kaltashov IA. Mass spectrometry study of a transferrin-based protein drug reveals the key role of protein aggregation for successful oral delivery. Proc Natl Acad Sci U S A. 2012 Aug 21; 109(34):13544-8.
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Kaltashov IA, Abzalimov RR. Do ionic charges in ESI MS provide useful information on macromolecular structure? J Am Soc Mass Spectrom. 2008 Sep; 19(9):1239-46.
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Gu Z, Zitzewitz JA, Matthews CR. Mapping the structure of folding cores in TIM barrel proteins by hydrogen exchange mass spectrometry: the roles of motif and sequence for the indole-3-glycerol phosphate synthase from Sulfolobus solfataricus. J Mol Biol. 2007 Apr 27; 368(2):582-94.
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Carraway RE, Mitra SP, Cochrane DE. Pro-xenopsin(s) in vesicles of mammalian brain, liver, stomach and intestine is apparently released into blood and cerebral spinal fluid. Regul Pept. 2000 Nov 24; 95(1-3):115-24.
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Degolier TF, Duke GE, Carraway RE. Neurotensin decreases pepsin output and gastrointestinal motility in chickens. Poult Sci. 1997 Oct; 76(10):1435-9.
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Woods KL, Kiefe C, Graham DY. How accurate is the determination of blood in gastric juice? Comparison of peroxidase and porphyrin methods. Aliment Pharmacol Ther. 1996 Jun; 10(3):333-7.
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Yamauchi K, Tomita M, Giehl TJ, Ellison RT. Antibacterial activity of lactoferrin and a pepsin-derived lactoferrin peptide fragment. Infect Immun. 1993 Feb; 61(2):719-28.
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Thompson EW, Br?nner N, Torri J, Johnson MD, Boulay V, Wright A, Lippman ME, Steeg PS, Clarke R. The invasive and metastatic properties of hormone-independent but hormone-responsive variants of MCF-7 human breast cancer cells. Clin Exp Metastasis. 1993 Jan; 11(1):15-26.
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Carraway RE, Mitra SP, Salmonsen R. Pepsin-mediated processing of synthetic precursor-like sequence yields neurotensin-like peptide. Peptides. 1992 Mar-Apr; 13(2):319-22.
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Carraway RE, Mitra SP, Spaulding G. Posttranslational processing of the neurotensin/neuromedin-N precursor. Ann N Y Acad Sci. 1992; 668:1-16.