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Multiple proteolytic events in caspase-6 self-activation impact conformations of discrete structural regions.
Allosteric inhibition of the NS2B-NS3 protease from dengue virus.
Caspase-9 CARD?:?core domain interactions require a properly formed active site.
Tri-arginine exosite patch of caspase-6 recruits substrates for hydrolysis.
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Tri-arginine exosite patch of caspase-6 recruits substrates for hydrolysis.
MacPherson DJ, Mills CL, Ondrechen MJ, Hardy JA. Tri-arginine exosite patch of caspase-6 recruits substrates for hydrolysis. J Biol Chem. 2019 01 04; 294(1):71-88.
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PubMed
subject areas
Amino Acid Substitution
Arginine
Caspase 6
Humans
Hydrolysis
Mutation, Missense
Neoplasm Proteins
Neoplasms
Neurodegenerative Diseases
Protein Domains
authors with profiles
Jeanne A Hardy BS, PhD