Interferon-Induced Helicase, IFIH1

"Interferon-Induced Helicase, IFIH1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A DEAD box RNA helicase that contains two N-terminal CASPASE ACTIVATION AND RECRUITMENT DOMAINS. It functions as a sensor of viral NUCLEIC ACIDS such as DOUBLE-STRANDED RNA and activates the INNATE IMMUNE RESPONSE by inducing the expression of INTERFERON-ALPHA and INTERFERON-BETA. It may also regulate cell growth and APOPTOSIS.

Descriptor ID	D000072640
MeSH Number(s)	D08.811.913.696.445.735.720.249.875
Concept/Terms	Interferon-Induced Helicase, IFIH1 Interferon-Induced Helicase, IFIH1 Helicase, IFIH1 Interferon-Induced IFIH1 Interferon-Induced Helicase Interferon Induced Helicase, IFIH1 Helicard Melanoma Differentiation-Associated Protein 5 Melanoma Differentiation Associated Protein 5 CADM-140 Autoantigen Autoantigen, CADM-140 CADM 140 Autoantigen Interferon Induced with Helicase C Domain 1 Interferon-Induced Helicase C Domain-Containing Protein 1 Interferon Induced Helicase C Domain Containing Protein 1 IFIH1 Protein

Below are MeSH descriptors whose meaning is more general than "Interferon-Induced Helicase, IFIH1".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Transferases [D08.811.913]
Phosphotransferases [D08.811.913.696]
Nucleotidyltransferases [D08.811.913.696.445]
RNA Nucleotidyltransferases [D08.811.913.696.445.735]
RNA Helicases [D08.811.913.696.445.735.720]
DEAD-box RNA Helicases [D08.811.913.696.445.735.720.249]
Interferon-Induced Helicase, IFIH1 [D08.811.913.696.445.735.720.249.875]

Below are MeSH descriptors whose meaning is related to "Interferon-Induced Helicase, IFIH1".

Below are MeSH descriptors whose meaning is more specific than "Interferon-Induced Helicase, IFIH1".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Interferon-Induced Helicase, IFIH1" by people in this website by year, and whether "Interferon-Induced Helicase, IFIH1" was a major or minor topic of these publications.

Bar chart showing 7 publications over 4 distinct years, with a maximum of 2 publications in 2010 and 2013 and 2024

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2010	0	2	2
2013	0	2	2
2014	0	1	1
2024	2	0	2

Below are the most recent publications written about "Interferon-Induced Helicase, IFIH1" by people in Profiles.

Guney MH, Nagalekshmi K, McCauley SM, Carbone C, Aydemir O, Luban J. IFIH1 (MDA5) is required for innate immune detection of intron-containing RNA expressed from the HIV-1 provirus. Proc Natl Acad Sci U S A. 2024 Jul 16; 121(29):e2404349121.

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Bazzone LE, Zhu J, King M, Liu G, Guo Z, MacKay CR, Kyawe PP, Qaisar N, Rojas-Quintero J, Owen CA, Brass AL, McDougall W, Baer CE, Cashman T, Trivedi CM, Gack MU, Finberg RW, Kurt-Jones EA. ADAM9 promotes type I interferon-mediated innate immunity during encephalomyocarditis virus infection. Nat Commun. 2024 May 16; 15(1):4153.

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Narayan K, Waggoner L, Pham ST, Hendricks GL, Waggoner SN, Conlon J, Wang JP, Fitzgerald KA, Kang J. TRIM13 is a negative regulator of MDA5-mediated type I interferon production. J Virol. 2014 Sep; 88(18):10748-57.

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Liehl P, Zuzarte-Lu?s V, Chan J, Zillinger T, Baptista F, Carapau D, Konert M, Hanson KK, Carret C, Lassnig C, M?ller M, Kalinke U, Saeed M, Chora AF, Golenbock DT, Strobl B, Prud?ncio M, Coelho LP, Kappe SH, Superti-Furga G, Pichlmair A, Vig?rio AM, Rice CM, Fitzgerald KA, Barchet W, Mota MM. Host-cell sensors for Plasmodium activate innate immunity against liver-stage infection. Nat Med. 2014 Jan; 20(1):47-53.

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Wies E, Wang MK, Maharaj NP, Chen K, Zhou S, Finberg RW, Gack MU. Dephosphorylation of the RNA sensors RIG-I and MDA5 by the phosphatase PP1 is essential for innate immune signaling. Immunity. 2013 Mar 21; 38(3):437-49.

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Robinson T, Kariuki SN, Franek BS, Kumabe M, Kumar AA, Badaracco M, Mikolaitis RA, Guerrero G, Utset TO, Drevlow BE, Zaacks LS, Grober JS, Cohen LM, Kirou KA, Crow MK, Jolly M, Niewold TB. Autoimmune disease risk variant of IFIH1 is associated with increased sensitivity to IFN-a and serologic autoimmunity in lupus patients. J Immunol. 2011 Aug 01; 187(3):1298-303.

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Zhou S, Cerny AM, Zacharia A, Fitzgerald KA, Kurt-Jones EA, Finberg RW. Induction and inhibition of type I interferon responses by distinct components of lymphocytic choriomeningitis virus. J Virol. 2010 Sep; 84(18):9452-62.

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Wang JP, Cerny A, Asher DR, Kurt-Jones EA, Bronson RT, Finberg RW. MDA5 and MAVS mediate type I interferon responses to coxsackie B virus. J Virol. 2010 Jan; 84(1):254-60.

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