DEAD Box Protein 58

"DEAD Box Protein 58" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A DEAD-box RNA helicase that contains an N-terminal DEATH-LIKE DOMAIN, AAA+ ATPase domain, and C-terminal RNA HELICASE activity. It functions as an innate immune receptor through its recognition of viral nucleic acids. It also induces the expression of INTERFERON TYPE I and proinflammatory CYTOKINES. Its ligands include: 5'-triphosphorylated SINGLE-STRANDED RNA, DOUBLE-STRANDED RNA (dsRNA), and short dsRNA (less than 1 kb in length).

Descriptor ID	D000071457
MeSH Number(s)	D08.811.913.696.445.735.720.249.750
Concept/Terms	DEAD Box Protein 58 DEAD Box Protein 58 DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 58 Probable ATP-Dependent RNA Helicase DDX58 Probable ATP Dependent RNA Helicase DDX58 RIG-I-like Receptor 1 RIG I like Receptor 1

Below are MeSH descriptors whose meaning is more general than "DEAD Box Protein 58".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Transferases [D08.811.913]
Phosphotransferases [D08.811.913.696]
Nucleotidyltransferases [D08.811.913.696.445]
RNA Nucleotidyltransferases [D08.811.913.696.445.735]
RNA Helicases [D08.811.913.696.445.735.720]
DEAD-box RNA Helicases [D08.811.913.696.445.735.720.249]
DEAD Box Protein 58 [D08.811.913.696.445.735.720.249.750]

Below are MeSH descriptors whose meaning is related to "DEAD Box Protein 58".

Below are MeSH descriptors whose meaning is more specific than "DEAD Box Protein 58".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "DEAD Box Protein 58" by people in this website by year, and whether "DEAD Box Protein 58" was a major or minor topic of these publications.

Bar chart showing 13 publications over 6 distinct years, with a maximum of 4 publications in 2009

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Year	Minor Topic	Total
2007	1	1
2009	4	4
2010	2	2
2011	2	2
2012	1	1
2013	3	3

Below are the most recent publications written about "DEAD Box Protein 58" by people in Profiles.

Hou J, Zhou Y, Zheng Y, Fan J, Zhou W, Ng IO, Sun H, Qin L, Qiu S, Lee JM, Lo CM, Man K, Yang Y, Yang Y, Yang Y, Zhang Q, Zhu X, Li N, Wang Z, Ding G, Zhuang SM, Zheng L, Luo X, Xie Y, Liang A, Wang Z, Zhang M, Xia Q, Liang T, Yu Y, Cao X. Hepatic RIG-I predicts survival and interferon-a therapeutic response in hepatocellular carcinoma. Cancer Cell. 2014 Jan 13; 25(1):49-63.

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Wies E, Wang MK, Maharaj NP, Chen K, Zhou S, Finberg RW, Gack MU. Dephosphorylation of the RNA sensors RIG-I and MDA5 by the phosphatase PP1 is essential for innate immune signaling. Immunity. 2013 Mar 21; 38(3):437-49.

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Ermler ME, Yerukhim E, Schriewer J, Schattgen S, Traylor Z, Wespiser AR, Caffrey DR, Chen ZJ, King CH, Gale M, Colonna M, Fitzgerald KA, Buller RM, Hise AG. RNA helicase signaling is critical for type i interferon production and protection against Rift Valley fever virus during mucosal challenge. J Virol. 2013 May; 87(9):4846-60.

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Rajsbaum R, Albrecht RA, Wang MK, Maharaj NP, Versteeg GA, Nistal-Vill?n E, Garc?a-Sastre A, Gack MU. Species-specific inhibition of RIG-I ubiquitination and IFN induction by the influenza A virus NS1 protein. PLoS Pathog. 2012; 8(11):e1003059.

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Maharaj NP, Wies E, Stoll A, Gack MU. Conventional protein kinase C-a (PKC-a) and PKC-? negatively regulate RIG-I antiviral signal transduction. J Virol. 2012 Feb; 86(3):1358-71.

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Stutz A, Bertheloot D, Latz E. Innate immune receptors for nucleic acids. Methods Mol Biol. 2011; 748:69-82.

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Zhou S, Cerny AM, Zacharia A, Fitzgerald KA, Kurt-Jones EA, Finberg RW. Induction and inhibition of type I interferon responses by distinct components of lymphocytic choriomeningitis virus. J Virol. 2010 Sep; 84(18):9452-62.

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Nistal-Vill?n E, Gack MU, Mart?nez-Delgado G, Maharaj NP, Inn KS, Yang H, Wang R, Aggarwal AK, Jung JU, Garc?a-Sastre A. Negative role of RIG-I serine 8 phosphorylation in the regulation of interferon-beta production. J Biol Chem. 2010 Jun 25; 285(26):20252-61.

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Goutagny N, Jiang Z, Tian J, Parroche P, Schickli J, Monks BG, Ulbrandt N, Ji H, Kiener PA, Coyle AJ, Fitzgerald KA. Cell type-specific recognition of human metapneumoviruses (HMPVs) by retinoic acid-inducible gene I (RIG-I) and TLR7 and viral interference of RIG-I ligand recognition by HMPV-B1 phosphoprotein. J Immunol. 2010 Feb 01; 184(3):1168-79.

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Ablasser A, Bauernfeind F, Hartmann G, Latz E, Fitzgerald KA, Hornung V. RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III-transcribed RNA intermediate. Nat Immunol. 2009 Oct; 10(10):1065-72.

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