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Cytokine gene expression in islets and thyroids of BB rats. IFN-gamma and IL-12p40 mRNA increase with age in both diabetic and insulin-treated nondiabetic BB rats.
Human insulin as both antigen and protector in type 1 diabetes.
Levels of Art2+ cells but not soluble Art2 protein correlate with expression of autoimmune diabetes in the BB rat.
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Human insulin as both antigen and protector in type 1 diabetes.
Amdare NP, Shultz LD, Greiner DL, DiLorenzo TP. Human insulin as both antigen and protector in type 1 diabetes. Eur J Immunol. 2024 Sep; 54(9):e2350949.
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PubMed
subject areas
Animals
Autoantigens
CD4-Positive T-Lymphocytes
CD8-Positive T-Lymphocytes
Diabetes Mellitus, Type 1
Epitopes, T-Lymphocyte
Female
Humans
Insulin
Islets of Langerhans
Mice
Mice, Inbred NOD
Mice, Transgenic
Thymus Gland
authors with profiles
Dale L Greiner PhD
Leonard Donald Shultz PhD