Synthesis and pharmacological characterization of a series of geometrically constrained 5-HT(2A/2C) receptor ligands.
Chambers JJ, Parrish JC, Jensen NH, Kurrasch-Orbaugh DM, Marona-Lewicka D, Nichols DE. Synthesis and pharmacological characterization of a series of geometrically constrained 5-HT(2A/2C) receptor ligands. J Med Chem. 2003 Jul 31; 46(16):3526-35.
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Animals
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Binding, Competitive
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Cells, Cultured
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Discrimination Learning
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Furans
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Heterocyclic Compounds, 3-Ring
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Inositol Phosphates
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Ligands
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Lysergic Acid Diethylamide
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Male
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Molecular Conformation
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Radioligand Assay
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Rats
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Rats, Sprague-Dawley
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Receptor, Serotonin, 5-HT2A
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Receptor, Serotonin, 5-HT2C
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Receptors, Serotonin
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Receptors, Serotonin, 5-HT1
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Serotonin Receptor Agonists
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Stereoisomerism
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Structure-Activity Relationship