Targeting gastrin-releasing peptide receptors on small cell lung cancer cells with a bispecific molecule that activates polyclonal T lymphocytes.
Zhou J, Chen J, Zhong R, Mokotoff M, Shultz LD, Ball ED. Targeting gastrin-releasing peptide receptors on small cell lung cancer cells with a bispecific molecule that activates polyclonal T lymphocytes. Clin Cancer Res. 2006 Apr 01; 12(7 Pt 1):2224-31.
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Animals
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Antibodies, Bispecific
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Antibodies, Monoclonal
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Antineoplastic Agents
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Apoptosis
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Binding Sites
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Carcinoma, Small Cell
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Cell Line, Tumor
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Cell Proliferation
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Cytotoxicity Tests, Immunologic
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Disease Models, Animal
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Humans
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Immunoconjugates
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Immunotherapy
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Interferon-gamma
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Lung Neoplasms
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Mice
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Mice, Inbred NOD
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Muromonab-CD3
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Oxytocin
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Receptors, Bombesin
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Structure-Activity Relationship
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T-Lymphocytes
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Transplantation, Heterologous
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Tumor Cells, Cultured
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Xenograft Model Antitumor Assays