Notch signaling mediates G1/S cell-cycle progression in T cells via cyclin D3 and its dependent kinases.
Joshi I, Minter LM, Telfer J, Demarest RM, Capobianco AJ, Aster JC, Sicinski P, Fauq A, Golde TE, Osborne BA. Notch signaling mediates G1/S cell-cycle progression in T cells via cyclin D3 and its dependent kinases. Blood. 2009 Feb 19; 113(8):1689-98.
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Animals
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CD4-Positive T-Lymphocytes
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Cell Line, Tumor
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Cyclin D3
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Cyclin-Dependent Kinase 4
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Cyclin-Dependent Kinase 6
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Cyclins
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G1 Phase
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Gene Expression Regulation, Leukemic
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Gene Expression Regulation, Neoplastic
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Humans
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Lymphoma, T-Cell
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Mice
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Mice, Inbred C57BL
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NF-kappa B
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Phosphorylation
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Precursor Cell Lymphoblastic Leukemia-Lymphoma
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Promoter Regions, Genetic
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Proto-Oncogene Proteins
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Receptor, Notch1
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Receptor, Notch2
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Receptor, Notch3
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Receptor, Notch4
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Receptors, Notch
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Retinoblastoma Protein
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S Phase
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Signal Transduction