 Transforming Growth Factor beta
"Transforming Growth Factor beta" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A factor synthesized in a wide variety of tissues. It acts synergistically with TGF-alpha in inducing phenotypic transformation and can also act as a negative autocrine growth factor. TGF-beta has a potential role in embryonal development, cellular differentiation, hormone secretion, and immune function. TGF-beta is found mostly as homodimer forms of separate gene products TGF-beta1, TGF-beta2 or TGF-beta3. Heterodimers composed of TGF-beta1 and 2 (TGF-beta1.2) or of TGF-beta2 and 3 (TGF-beta2.3) have been isolated. The TGF-beta proteins are synthesized as precursor proteins.
| Descriptor ID |
D016212
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| MeSH Number(s) |
D12.644.276.374.687 D12.644.276.954.800.720 D12.644.276.963.720 D12.776.467.374.687 D12.776.467.942.800.720 D12.776.467.960.720 D23.529.374.687 D23.529.942.800.720 D23.529.960.720
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| Concept/Terms |
Transforming Growth Factor beta- Transforming Growth Factor beta
- Milk Growth Factor
- Factor, Milk Growth
- Growth Factor, Milk
- TGF-beta
- TGFbeta
- Platelet Transforming Growth Factor
- Bone-Derived Transforming Growth Factor
- Bone Derived Transforming Growth Factor
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Below are MeSH descriptors whose meaning is more general than "Transforming Growth Factor beta".
Below are MeSH descriptors whose meaning is more specific than "Transforming Growth Factor beta".
This graph shows the total number of publications written about "Transforming Growth Factor beta" by people in this website by year, and whether "Transforming Growth Factor beta" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1991 | 2 | 2 | 4 | | 1992 | 1 | 0 | 1 | | 1993 | 1 | 1 | 2 | | 1994 | 1 | 2 | 3 | | 1995 | 2 | 1 | 3 | | 1996 | 1 | 1 | 2 | | 1997 | 1 | 2 | 3 | | 1999 | 2 | 1 | 3 | | 2002 | 3 | 3 | 6 | | 2003 | 2 | 2 | 4 | | 2004 | 4 | 5 | 9 | | 2005 | 6 | 6 | 12 | | 2006 | 5 | 3 | 8 | | 2007 | 5 | 1 | 6 | | 2008 | 4 | 3 | 7 | | 2009 | 3 | 4 | 7 | | 2010 | 3 | 5 | 8 | | 2011 | 5 | 3 | 8 | | 2012 | 2 | 0 | 2 | | 2013 | 3 | 4 | 7 | | 2014 | 1 | 4 | 5 | | 2015 | 0 | 6 | 6 | | 2016 | 0 | 1 | 1 | | 2017 | 1 | 3 | 4 | | 2018 | 2 | 0 | 2 | | 2019 | 1 | 0 | 1 | | 2021 | 0 | 1 | 1 |
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Below are the most recent publications written about "Transforming Growth Factor beta" by people in Profiles.
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Kim K, Wang X, Ragonnaud E, Bodogai M, Illouz T, DeLuca M, McDevitt RA, Gusev F, Okun E, Rogaev E, Biragyn A. Therapeutic B-cell depletion reverses progression of Alzheimer's disease. Nat Commun. 2021 04 12; 12(1):2185.
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Hang L, Kumar S, Blum AM, Urban JF, Fantini MC, Weinstock JV. Heligmosomoides polygyrus bakeri Infection Decreases Smad7 Expression in Intestinal CD4+ T Cells, Which Allows TGF-ß to Induce IL-10-Producing Regulatory T Cells That Block Colitis. J Immunol. 2019 04 15; 202(8):2473-2481.
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Li Y, Guan X, Liu W, Chen HL, Truscott J, Beyatli S, Metwali A, Weiner GJ, Zavazava N, Blumberg RS, Urban JF, Blazar BR, Elliott DE, Ince MN. Helminth-Induced Production of TGF-ß and Suppression of Graft-versus-Host Disease Is Dependent on IL-4 Production by Host Cells. J Immunol. 2018 11 15; 201(10):2910-2922.
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Li Y, Liu W, Guan X, Truscott J, Creemers JW, Chen HL, Pesu M, El Abiad RG, Karacay B, Urban JF, Elliott DE, Kaplan MH, Blazar BR, Ince MN. STAT6 and Furin Are Successive Triggers for the Production of TGF-ß by T Cells. J Immunol. 2018 11 01; 201(9):2612-2623.
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Woods K, Thigpen C, Wang JP, Park H, Hielscher A. Mechanically tuned 3 dimensional hydrogels support human mammary fibroblast growth and viability. BMC Cell Biol. 2017 Dec 16; 18(1):35.
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Tan TY, Gonzaga-Jauregui C, Bhoj EJ, Strauss KA, Brigatti K, Puffenberger E, Li D, Xie L, Das N, Skubas I, Deckelbaum RA, Hughes V, Brydges S, Hatsell S, Siao CJ, Dominguez MG, Economides A, Overton JD, Mayne V, Simm PJ, Jones BO, Eggers S, Le Guyader G, Pelluard F, Haack TB, Sturm M, Riess A, Waldmueller S, Hofbeck M, Steindl K, Joset P, Rauch A, Hakonarson H, Baker NL, Farlie PG. Monoallelic BMP2 Variants Predicted to Result in Haploinsufficiency Cause Craniofacial, Skeletal, and Cardiac Features Overlapping Those of 20p12 Deletions. Am J Hum Genet. 2017 Dec 07; 101(6):985-994.
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Gregory KJ, Morin SM, Schneider SS. Regulation of early growth response 2 expression by secreted frizzled related protein 1. BMC Cancer. 2017 Jul 07; 17(1):473.
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Gonzalez D, Contreras O, Rebolledo DL, Espinoza JP, van Zundert B, Brandan E. ALS skeletal muscle shows enhanced TGF-ß signaling, fibrosis and induction of fibro/adipogenic progenitor markers. PLoS One. 2017; 12(5):e0177649.
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Barouch DH, Ghneim K, Bosche WJ, Li Y, Berkemeier B, Hull M, Bhattacharyya S, Cameron M, Liu J, Smith K, Borducchi E, Cabral C, Peter L, Brinkman A, Shetty M, Li H, Gittens C, Baker C, Wagner W, Lewis MG, Colantonio A, Kang HJ, Li W, Lifson JD, Piatak M, Sekaly RP. Rapid Inflammasome Activation following Mucosal SIV Infection of Rhesus Monkeys. Cell. 2016 Apr 21; 165(3):656-67.
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Camci-Unal G, Newsome D, Eustace BK, Whitesides GM. Fibroblasts Enhance Migration of Human Lung Cancer Cells in a Paper-Based Coculture System. Adv Healthc Mater. 2016 Mar; 5(6):641-7, 626.
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