RNA, Small Interfering

"RNA, Small Interfering" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Small double-stranded, non-protein coding RNAs (21-31 nucleotides) involved in GENE SILENCING functions, especially RNA INTERFERENCE (RNAi). Endogenously, siRNAs are generated from dsRNAs (RNA, DOUBLE-STRANDED) by the same ribonuclease, Dicer, that generates miRNAs (MICRORNAS). The perfect match of the siRNAs' antisense strand to their target RNAs mediates RNAi by siRNA-guided RNA cleavage. siRNAs fall into different classes including trans-acting siRNA (tasiRNA), repeat-associated RNA (rasiRNA), small-scan RNA (scnRNA), and Piwi protein-interacting RNA (piRNA) and have different specific gene silencing functions.

Descriptor ID	D034741
MeSH Number(s)	D13.150.650.700 D13.444.735.150.700 D13.444.735.790.552.875
Concept/Terms	RNA, Small Interfering RNA, Small Interfering Interfering RNA, Small Short Interfering RNA Interfering RNA, Short RNA, Short Interfering Small Interfering RNA siRNA Piwi-Interacting RNA Piwi-Interacting RNA Piwi Interacting RNA RNA, Piwi-Interacting RNA, Piwi Interacting piRNA Short Hairpin RNA Short Hairpin RNA Hairpin RNA, Short RNA, Short Hairpin Small Hairpin RNA Hairpin RNA, Small RNA, Small Hairpin shRNA Repeat-Associated siRNA Repeat-Associated siRNA Repeat Associated siRNA siRNA, Repeat-Associated siRNA, Repeat Associated Scan RNA Scan RNA scnRNA Small Scan RNA RNA, Small Scan Scan RNA, Small RNA, Scan Trans-Acting siRNA Trans-Acting siRNA Trans Acting siRNA tasiRNA siRNA, Trans-Acting siRNA, Trans Acting

Below are MeSH descriptors whose meaning is more general than "RNA, Small Interfering".

Chemicals and Drugs [D]
Nucleic Acids, Nucleotides, and Nucleosides [D13]
Antisense Elements (Genetics) [D13.150]
RNA, Antisense [D13.150.650]
RNA, Small Interfering [D13.150.650.700]
Nucleic Acids [D13.444]
RNA [D13.444.735]
RNA, Antisense [D13.444.735.150]
RNA, Small Interfering [D13.444.735.150.700]
RNA, Untranslated [D13.444.735.790]
RNA, Small Untranslated [D13.444.735.790.552]
RNA, Small Interfering [D13.444.735.790.552.875]

Below are MeSH descriptors whose meaning is related to "RNA, Small Interfering".

Below are MeSH descriptors whose meaning is more specific than "RNA, Small Interfering".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "RNA, Small Interfering" by people in this website by year, and whether "RNA, Small Interfering" was a major or minor topic of these publications.

Bar chart showing 512 publications over 24 distinct years, with a maximum of 34 publications in 2005 and 2009 and 2014

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2000	0	1	1
2001	0	1	1
2002	0	3	3
2003	9	9	18
2004	13	19	32
2005	14	20	34
2006	13	11	24
2007	12	9	21
2008	11	21	32
2009	15	19	34
2010	10	15	25
2011	11	17	28
2012	9	21	30
2013	12	19	31
2014	9	25	34
2015	10	18	28
2016	10	18	28
2017	10	8	18
2018	18	10	28
2019	18	9	27
2020	6	3	9
2021	7	7	14
2022	1	6	7
2023	1	4	5

Below are the most recent publications written about "RNA, Small Interfering" by people in Profiles.

Khvorova A. siRNAs-A New Class of Medicines. JAMA. 2023 06 27; 329(24):2185-2186.

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O'Reilly D, Belgrad J, Ferguson C, Summers A, Sapp E, McHugh C, Mathews E, Boudi A, Buchwald J, Ly S, Moreno D, Furgal R, Luu E, Kennedy Z, Hariharan V, Monopoli K, Yang XW, Carroll J, DiFiglia M, Aronin N, Khvorova A. Di-valent siRNA-mediated silencing of MSH3 blocks somatic repeat expansion in mouse models of Huntington's disease. Mol Ther. 2023 Jun 07; 31(6):1661-1674.

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Ding YH, Ochoa HJ, Ishidate T, Shirayama M, Mello CC. The nuclear Argonaute HRDE-1 directs target gene re-localization and shuttles to nuage to promote small RNA-mediated inherited silencing. Cell Rep. 2023 05 30; 42(5):112408.

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Hariharan VN, Shin M, Chang CW, O'Reilly D, Biscans A, Yamada K, Guo Z, Somasundaran M, Tang Q, Monopoli K, Krishnamurthy PM, Devi G, McHugh N, Cooper DA, Echeverria D, Cruz J, Chan IL, Liu P, Lim SY, McConnell J, Singh SP, Hildebrand S, Sousa J, Davis SM, Kennedy Z, Ferguson C, Godinho BMDC, Thillier Y, Caiazzi J, Ly S, Muhuri M, Kelly K, Humphries F, Cousineau A, Parsi KM, Li Q, Wang Y, Maehr R, Gao G, Korkin D, McDougall WM, Finberg RW, Fitzgerald KA, Wang JP, Watts JK, Khvorova A. Divalent siRNAs are bioavailable in the lung and efficiently block SARS-CoV-2 infection. Proc Natl Acad Sci U S A. 2023 03 14; 120(11):e2219523120.

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Jeon T, Luther DC, Goswami R, Bell C, Nagaraj H, Cicek YA, Huang R, Mas-Rosario JA, Elia JL, Im J, Lee YW, Liu Y, Scaletti F, Farkas ME, Mager J, Rotello VM. Engineered Polymer-siRNA Polyplexes Provide Effective Treatment of Lung Inflammation. ACS Nano. 2023 03 14; 17(5):4315-4326.

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Bugide S, Edwards YJK, Gupta R, Green MR, Wajapeyee N. CBX5 loss drives EGFR inhibitor resistance and results in therapeutically actionable vulnerabilities in lung cancer. Proc Natl Acad Sci U S A. 2023 01 24; 120(4):e2218118120.

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Conroy F, Miller R, Alterman JF, Hassler MR, Echeverria D, Godinho BMDC, Knox EG, Sapp E, Sousa J, Yamada K, Mahmood F, Boudi A, Kegel-Gleason K, DiFiglia M, Aronin N, Khvorova A, Pfister EL. Chemical engineering of therapeutic siRNAs for allele-specific gene silencing in Huntington's disease models. Nat Commun. 2022 10 03; 13(1):5802.

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Ventura P, Sardh E, Longo N, Balwani M, Plutzky J, Gouya L, Phillips J, Rhyee S, Fanelli MJ, Sweetser MT, Petrides PE. Hyperhomocysteinemia in acute hepatic porphyria (AHP) and implications for treatment with givosiran. Expert Rev Gastroenterol Hepatol. 2022 Sep; 16(9):879-894.

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Biscans A, Ly S, McHugh N, Cooper DA, Khvorova A. Engineered ionizable lipid siRNA conjugates enhance endosomal escape but induce toxicity in vivo. J Control Release. 2022 09; 349:831-843.

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Arif A, Bailey S, Izumi N, Anzelon TA, Ozata DM, Andersson C, Gainetdinov I, MacRae IJ, Tomari Y, Zamore PD. GTSF1 accelerates target RNA cleavage by PIWI-clade Argonaute proteins. Nature. 2022 08; 608(7923):618-625.

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