Ubiquitin-Protein Ligases

"Ubiquitin-Protein Ligases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A diverse class of enzymes that interact with UBIQUITIN-CONJUGATING ENZYMES and ubiquitination-specific protein substrates. Each member of this enzyme group has its own distinct specificity for a substrate and ubiquitin-conjugating enzyme. Ubiquitin-protein ligases exist as both monomeric proteins multiprotein complexes.

Descriptor ID	D044767
MeSH Number(s)	D08.811.464.938.750
Concept/Terms	Ubiquitin-Protein Ligases Ubiquitin-Protein Ligases Ligases, Ubiquitin-Protein Ubiquitin Protein Ligases E3 Ubiquitin Ligase Ligase, E3 Ubiquitin Ubiquitin Ligase, E3 Ubiquitin-Protein Ligase E3 Ligase E3, Ubiquitin-Protein Ubiquitin Protein Ligase E3 Ubiquitin Ligase E3 Ligase E3, Ubiquitin Ubiquitin-Protein Ligase Ligase, Ubiquitin-Protein Ubiquitin Protein Ligase E3 Ligase Ligase, E3

Below are MeSH descriptors whose meaning is more general than "Ubiquitin-Protein Ligases".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Ligases [D08.811.464]
Ubiquitin-Protein Ligase Complexes [D08.811.464.938]
Ubiquitin-Protein Ligases [D08.811.464.938.750]

Below are MeSH descriptors whose meaning is related to "Ubiquitin-Protein Ligases".

Below are MeSH descriptors whose meaning is more specific than "Ubiquitin-Protein Ligases".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Ubiquitin-Protein Ligases" by people in this website by year, and whether "Ubiquitin-Protein Ligases" was a major or minor topic of these publications.

Bar chart showing 48 publications over 21 distinct years, with a maximum of 9 publications in 2014

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1999	0	2	2
2000	0	1	1
2001	1	0	1
2002	0	1	1
2003	0	1	1
2006	0	1	1
2007	1	0	1
2008	1	1	2
2009	2	4	6
2010	2	1	3
2011	2	1	3
2012	4	0	4
2013	2	1	3
2014	6	3	9
2016	2	1	3
2017	1	0	1
2018	1	0	1
2019	1	1	2
2021	1	0	1
2022	1	0	1
2024	1	0	1

Below are the most recent publications written about "Ubiquitin-Protein Ligases" by people in Profiles.

Wang F, Mehta P, Bach I. How does the Xist activator Rlim/Rnf12 regulate Xist expression? Biochem Soc Trans. 2024 Jun 26; 52(3):1099-1107.

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Segarra-Fas A, Espejo-Serrano C, Bustos F, Zhou H, Wang F, Toth R, Macartney T, Bach I, Nardocci G, Findlay GM. An RNF12-USP26 amplification loop drives germ cell specification and is disrupted by disease-associated mutations. Sci Signal. 2022 07 12; 15(742):eabm5995.

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Rushton MD, Saunderson EA, Patani H, Green MR, Ficz G. An shRNA kinase screen identifies regulators of UHRF1 stability and activity in mouse embryonic stem cells. Epigenetics. 2022 12; 17(12):1590-1607.

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Wang F, Gervasi MG, Bo?kovic A, Sun F, Rinaldi VD, Yu J, Wallingford MC, Tourzani DA, Mager J, Zhu LJ, Rando OJ, Visconti PE, Strittmatter L, Bach I. Deficient spermiogenesis in mice lacking Rlim. Elife. 2021 02 23; 10.

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Wu PH, Zamore PD. To Degrade a MicroRNA, Destroy Its Argonaute Protein. Mol Cell. 2021 01 21; 81(2):223-225.

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Swenson SA, Gilbreath TJ, Vahle H, Hynes-Smith RW, Graham JH, Law HC, Amador C, Woods NT, Green MR, Buckley SM. UBR5 HECT domain mutations identified in mantle cell lymphoma control maturation of B cells. Blood. 2020 07 16; 136(3):299-312.

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Park CS, Lewis AH, Chen TJ, Bridges CS, Shen Y, Suppipat K, Puppi M, Tomolonis JA, Pang PD, Mistretta TA, Ma L, Green MR, Rau R, Lacorazza HD. A KLF4-DYRK2-mediated pathway regulating self-renewal in CML stem cells. Blood. 2019 11 28; 134(22):1960-1972.

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Kim K, Dauphin A, Komurlu S, McCauley SM, Yurkovetskiy L, Carbone C, Diehl WE, Strambio-De-Castillia C, Campbell EM, Luban J. Cyclophilin A protects HIV-1 from restriction by human TRIM5a. Nat Microbiol. 2019 12; 4(12):2044-2051.

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Kim MJ, Min Y, Shim JH, Chun E, Lee KY. CRBN Is a Negative Regulator of Bactericidal Activity and Autophagy Activation Through Inhibiting the Ubiquitination of ECSIT and BECN1. Front Immunol. 2019; 10:2203.

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Deng P, Uma Naresh N, Du Y, Lamech LT, Yu J, Zhu LJ, Pukkila-Worley R, Haynes CM. Mitochondrial UPR repression during Pseudomonas aeruginosa infection requires the bZIP protein ZIP-3. Proc Natl Acad Sci U S A. 2019 03 26; 116(13):6146-6151.

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