Core Binding Factor alpha Subunits

"Core Binding Factor alpha Subunits" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A family of transcription factors that bind to the cofactor CORE BINDING FACTOR BETA SUBUNIT to form core binding factor. Family members contain a highly conserved DNA-binding domain known as the runt domain. They can act as both activators and repressors of expression of GENES involved in CELL DIFFERENTIATION and CELL CYCLE progression.

Descriptor ID	D050657
MeSH Number(s)	D12.776.930.155.200
Concept/Terms	Core Binding Factor alpha Subunits Core Binding Factor alpha Subunits Core Binding Factor alpha Proteins Runx Proteins Polyomavirus Enhancer A Binding Protein 2 Polyomavirus Enhancer Binding Protein 2, Alpha Subunit Runt Domain Factor Acute Myeloid Leukemia Proteins PEBP2A Transcription Factors Transcription Factors, PEBP2A

Below are MeSH descriptors whose meaning is more general than "Core Binding Factor alpha Subunits".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Transcription Factors [D12.776.930]
Core Binding Factors [D12.776.930.155]
Core Binding Factor alpha Subunits [D12.776.930.155.200]

Below are MeSH descriptors whose meaning is related to "Core Binding Factor alpha Subunits".

Below are MeSH descriptors whose meaning is more specific than "Core Binding Factor alpha Subunits".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Core Binding Factor alpha Subunits" by people in this website by year, and whether "Core Binding Factor alpha Subunits" was a major or minor topic of these publications.

Bar chart showing 17 publications over 7 distinct years, with a maximum of 4 publications in 2003 and 2004

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2002	0	3	3
2003	0	4	4
2004	0	4	4
2005	0	2	2
2007	1	1	2
2016	1	0	1
2018	1	0	1

Below are the most recent publications written about "Core Binding Factor alpha Subunits" by people in Profiles.

Hong D, Fritz AJ, Zaidi SK, van Wijnen AJ, Nickerson JA, Imbalzano AN, Lian JB, Stein JL, Stein GS. Epithelial-to-mesenchymal transition and cancer stem cells contribute to breast cancer heterogeneity. J Cell Physiol. 2018 12; 233(12):9136-9144.

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Illendula A, Gilmour J, Grembecka J, Tirumala VSS, Boulton A, Kuntimaddi A, Schmidt C, Wang L, Pulikkan JA, Zong H, Parlak M, Kuscu C, Pickin A, Zhou Y, Gao Y, Mishra L, Adli M, Castilla LH, Rajewski RA, Janes KA, Guzman ML, Bonifer C, Bushweller JH. Small Molecule Inhibitor of CBF?-RUNX Binding for RUNX Transcription Factor Driven Cancers. EBioMedicine. 2016 Jun; 8:117-131.

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Stein GS. Gene expression in nuclear microenvironments for biological control and cancer. Cancer Biol Ther. 2007 Nov; 6(11):1817-21.

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Kuo YH, Gerstein RM, Castilla LH. Cbfbeta-SMMHC impairs differentiation of common lymphoid progenitors and reveals an essential role for RUNX in early B-cell development. Blood. 2008 Feb 01; 111(3):1543-51.

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Zaidi SK, Young DW, Javed A, Pratap J, Montecino M, van Wijnen A, Lian JB, Stein JL, Stein GS. Nuclear microenvironments in biological control and cancer. Nat Rev Cancer. 2007 Jun; 7(6):454-63.

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Stein GS, Lian JB, Stein JL, van Wijnen AJ, Javed A, Montecino M, Zaidi SK, Young DW, Choi JY, Pratap J. Combinatorial organization of the transcriptional regulatory machinery in biological control and cancer. Adv Enzyme Regul. 2005; 45:136-54.

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Javed A, Barnes GL, Pratap J, Antkowiak T, Gerstenfeld LC, van Wijnen AJ, Stein JL, Lian JB, Stein GS. Impaired intranuclear trafficking of Runx2 (AML3/CBFA1) transcription factors in breast cancer cells inhibits osteolysis in vivo. Proc Natl Acad Sci U S A. 2005 Feb 01; 102(5):1454-9.

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Young DW, Zaidi SK, Furcinitti PS, Javed A, van Wijnen AJ, Stein JL, Lian JB, Stein GS. Quantitative signature for architectural organization of regulatory factors using intranuclear informatics. J Cell Sci. 2004 Oct 01; 117(Pt 21):4889-96.

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Gutierrez S, Liu J, Javed A, Montecino M, Stein GS, Lian JB, Stein JL. The vitamin D response element in the distal osteocalcin promoter contributes to chromatin organization of the proximal regulatory domain. J Biol Chem. 2004 Oct 15; 279(42):43581-8.

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Stein GS, Lian JB, van Wijnen AJ, Stein JL, Montecino M, Javed A, Zaidi SK, Young DW, Choi JY, Pockwinse SM. Runx2 control of organization, assembly and activity of the regulatory machinery for skeletal gene expression. Oncogene. 2004 May 24; 23(24):4315-29.

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