Codon, Initiator

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"Codon, Initiator" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A codon that directs initiation of protein translation (TRANSLATION, GENETIC) by stimulating the binding of initiator tRNA (RNA, TRANSFER, MET). In prokaryotes, the codons AUG or GUG can act as initiators while in eukaryotes, AUG is the only initiator codon.

Descriptor ID	D018387
MeSH Number(s)	D13.444.735.544.355.225 G05.360.335.355.225 G05.360.340.024.340.137.190.225
Concept/Terms	Codon, Initiator Codon, Initiator Codons, Initiator Initiator Codons Initiator Codon Start Codon Codon, Start Codons, Start Start Codons Codon, Initiation Codons, Initiation Initiation Codon Initiation Codons

Below are MeSH descriptors whose meaning is more general than "Codon, Initiator".

Chemicals and Drugs [D]
Nucleic Acids, Nucleotides, and Nucleosides [D13]
Nucleic Acids [D13.444]
RNA [D13.444.735]
RNA, Messenger [D13.444.735.544]
Codon [D13.444.735.544.355]
Codon, Initiator [D13.444.735.544.355.225]
Biological Sciences [G]
Genetic Phenomena [G05]
Genetic Structures [G05.360]
Genetic Code [G05.360.335]
Codon [G05.360.335.355]
Codon, Initiator [G05.360.335.355.225]
Genome [G05.360.340]
Genome Components [G05.360.340.024]
Genes [G05.360.340.024.340]
Gene Components [G05.360.340.024.340.137]
Codon [G05.360.340.024.340.137.190]
Codon, Initiator [G05.360.340.024.340.137.190.225]

Below are MeSH descriptors whose meaning is related to "Codon, Initiator".

Below are MeSH descriptors whose meaning is more specific than "Codon, Initiator".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Codon, Initiator" by people in this website by year, and whether "Codon, Initiator" was a major or minor topic of these publications.

Bar chart showing 11 publications over 10 distinct years, with a maximum of 2 publications in 2000

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2000	0	2	2
2003	0	1	1
2005	0	1	1
2008	0	1	1
2013	0	1	1
2014	1	0	1
2015	1	0	1
2016	0	1	1
2017	0	1	1
2023	0	1	1

Below are the most recent publications written about "Codon, Initiator" by people in Profiles.

Sonobe Y, Lee S, Krishnan G, Gu Y, Kwon DY, Gao FB, Roos RP, Kratsios P. Translation of dipeptide repeat proteins in C9ORF72 ALS/FTD through unique and redundant AUG initiation codons. Elife. 2023 09 07; 12.

View in: PubMed
Gao FB, Richter JD, Cleveland DW. Rethinking Unconventional Translation in Neurodegeneration. Cell. 2017 Nov 16; 171(5):994-1000.

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Cenik C, Chua HN, Singh G, Akef A, Snyder MP, Palazzo AF, Moore MJ, Roth FP. A common class of transcripts with 5'-intron depletion, distinct early coding sequence features, and N1-methyladenosine modification. RNA. 2017 03; 23(3):270-283.

View in: PubMed
Svidritskiy E, Korostelev AA. Ribosome Structure Reveals Preservation of Active Sites in the Presence of a P-Site Wobble Mismatch. Structure. 2015 Nov 03; 23(11):2155-61.

View in: PubMed
Pulido R, Baker SJ, Barata JT, Carracedo A, Cid VJ, Chin-Sang ID, Dav? V, den Hertog J, Devreotes P, Eickholt BJ, Eng C, Furnari FB, Georgescu MM, Gericke A, Hopkins B, Jiang X, Lee SR, L?sche M, Malaney P, Matias-Guiu X, Molina M, Pandolfi PP, Parsons R, Pinton P, Rivas C, Rocha RM, Rodr?guez MS, Ross AH, Serrano M, Stambolic V, Stiles B, Suzuki A, Tan SS, Tonks NK, Trotman LC, Wolff N, Woscholski R, Wu H, Leslie NR. A unified nomenclature and amino acid numbering for human PTEN. Sci Signal. 2014 Jul 01; 7(332):pe15.

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Shell SS, Prestwich EG, Baek SH, Shah RR, Sassetti CM, Dedon PC, Fortune SM. DNA methylation impacts gene expression and ensures hypoxic survival of Mycobacterium tuberculosis. PLoS Pathog. 2013; 9(7):e1003419.

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Amrani N, Ghosh S, Mangus DA, Jacobson A. Translation factors promote the formation of two states of the closed-loop mRNP. Nature. 2008 Jun 26; 453(7199):1276-80.

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Raisner RM, Hartley PD, Meneghini MD, Bao MZ, Liu CL, Schreiber SL, Rando OJ, Madhani HD. Histone variant H2A.Z marks the 5' ends of both active and inactive genes in euchromatin. Cell. 2005 Oct 21; 123(2):233-48.

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Puopolo KM, Madoff LC. Upstream short sequence repeats regulate expression of the alpha C protein of group B Streptococcus. Mol Microbiol. 2003 Nov; 50(3):977-91.

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Dejucq N, Simmons G, Clapham PR. T-cell line adaptation of human immunodeficiency virus type 1 strain SF162: effects on envelope, vpu and macrophage-tropism. J Gen Virol. 2000 Dec; 81(Pt 12):2899-2904.

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