Cystic Fibrosis Transmembrane Conductance Regulator

"Cystic Fibrosis Transmembrane Conductance Regulator" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A chloride channel that regulates secretion in many exocrine tissues. Abnormalities in the CFTR gene have been shown to cause cystic fibrosis. (Hum Genet 1994;93(4):364-8)

Descriptor ID	D019005
MeSH Number(s)	D12.776.157.530.100.304.500 D12.776.157.530.400.175.125 D12.776.157.530.450.074.500.500.500.500 D12.776.543.550.450.175.125 D12.776.543.585.100.304.500 D12.776.543.585.400.175.125 D12.776.543.585.450.074.500.500.500.500
Concept/Terms	Cystic Fibrosis Transmembrane Conductance Regulator Cystic Fibrosis Transmembrane Conductance Regulator CFTR Protein Protein, CFTR Chloride channels, ATP-gated CFTR Chloride channels, ATP gated CFTR

Below are MeSH descriptors whose meaning is more general than "Cystic Fibrosis Transmembrane Conductance Regulator".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Carrier Proteins [D12.776.157]
Membrane Transport Proteins [D12.776.157.530]
ATP-Binding Cassette Transporters [D12.776.157.530.100]
Multidrug Resistance-Associated Proteins [D12.776.157.530.100.304]
Cystic Fibrosis Transmembrane Conductance Regulator [D12.776.157.530.100.304.500]
Ion Channels [D12.776.157.530.400]
Chloride Channels [D12.776.157.530.400.175]
Cystic Fibrosis Transmembrane Conductance Regulator [D12.776.157.530.400.175.125]
Ion Pumps [D12.776.157.530.450]
Anion Transport Proteins [D12.776.157.530.450.074]
Organic Anion Transporters [D12.776.157.530.450.074.500]
Organic Anion Transporters, ATP-Dependent [D12.776.157.530.450.074.500.500]
Multidrug Resistance-Associated Proteins [D12.776.157.530.450.074.500.500.500]
Cystic Fibrosis Transmembrane Conductance Regulator [D12.776.157.530.450.074.500.500.500.500]
Membrane Proteins [D12.776.543]
Membrane Glycoproteins [D12.776.543.550]
Ion Channels [D12.776.543.550.450]
Chloride Channels [D12.776.543.550.450.175]
Cystic Fibrosis Transmembrane Conductance Regulator [D12.776.543.550.450.175.125]
Membrane Transport Proteins [D12.776.543.585]
ATP-Binding Cassette Transporters [D12.776.543.585.100]
Multidrug Resistance-Associated Proteins [D12.776.543.585.100.304]
Cystic Fibrosis Transmembrane Conductance Regulator [D12.776.543.585.100.304.500]
Ion Channels [D12.776.543.585.400]
Chloride Channels [D12.776.543.585.400.175]
Cystic Fibrosis Transmembrane Conductance Regulator [D12.776.543.585.400.175.125]
Ion Pumps [D12.776.543.585.450]
Anion Transport Proteins [D12.776.543.585.450.074]
Organic Anion Transporters [D12.776.543.585.450.074.500]
Organic Anion Transporters, ATP-Dependent [D12.776.543.585.450.074.500.500]
Multidrug Resistance-Associated Proteins [D12.776.543.585.450.074.500.500.500]
Cystic Fibrosis Transmembrane Conductance Regulator [D12.776.543.585.450.074.500.500.500.500]

Below are MeSH descriptors whose meaning is related to "Cystic Fibrosis Transmembrane Conductance Regulator".

Below are MeSH descriptors whose meaning is more specific than "Cystic Fibrosis Transmembrane Conductance Regulator".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Cystic Fibrosis Transmembrane Conductance Regulator" by people in this website by year, and whether "Cystic Fibrosis Transmembrane Conductance Regulator" was a major or minor topic of these publications.

Bar chart showing 68 publications over 25 distinct years, with a maximum of 6 publications in 2008 and 2010

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1993	0	2	2
1994	0	1	1
1995	0	1	1
1996	3	2	5
1997	1	0	1
1998	3	0	3
1999	3	0	3
2001	0	2	2
2002	1	1	2
2003	2	0	2
2004	3	1	4
2005	2	3	5
2006	3	0	3
2007	4	0	4
2008	5	1	6
2009	1	2	3
2010	3	3	6
2011	1	2	3
2012	3	1	4
2013	1	0	1
2014	1	0	1
2016	3	0	3
2017	0	1	1
2018	1	0	1
2019	0	1	1

Below are the most recent publications written about "Cystic Fibrosis Transmembrane Conductance Regulator" by people in Profiles.

Tesell MA, Alper CJ, Bacon R, Greenwood BC, Lenz K, Jeffrey PL, Stevens K. Effect of Lumacaftor/Ivacaftor on Pulmonary Exacerbation Rates in Members with Cystic Fibrosis in a Medicaid Population. J Manag Care Spec Pharm. 2019 Sep; 25(9):1021-1025.

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Hart NJ, Aramandla R, Poffenberger G, Fayolle C, Thames AH, Bautista A, Spigelman AF, Babon JAB, DeNicola ME, Dadi PK, Bush WS, Balamurugan AN, Brissova M, Dai C, Prasad N, Bottino R, Jacobson DA, Drumm ML, Kent SC, MacDonald PE, Powers AC. Cystic fibrosis-related diabetes is caused by islet loss and inflammation. JCI Insight. 2018 04 19; 3(8).

View in: PubMed
Kaza N, Raju SV, Cadillac JM, Trombley JA, Rasmussen L, Tang L, Dohm E, Harrod KS, Rowe SM. Use of ferrets for electrophysiologic monitoring of ion transport. PLoS One. 2017; 12(10):e0186984.

View in: PubMed
Wilschanski M, Yaakov Y, Omari I, Zaman M, Martin CR, Cohen-Cymberknoh M, Shoseyov D, Kerem E, Dasilva D, Sheth S, Uluer A, O'Sullivan BP, Freedman S. Comparison of Nasal Potential Difference and Intestinal Current Measurements as Surrogate Markers for CFTR Function. J Pediatr Gastroenterol Nutr. 2016 11; 63(5):e92-e97.

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Puga Molina LC, Pinto NA, Torres Rodr?guez P, Romarowski A, Vicens Sanchez A, Visconti PE, Darszon A, Trevi?o CL, Buffone MG. Essential Role of CFTR in PKA-Dependent Phosphorylation, Alkalinization, and Hyperpolarization During Human Sperm Capacitation. J Cell Physiol. 2017 Jun; 232(6):1404-1414.

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Loring HS, ElMallah MK, Flotte TR. Development of rAAV2-CFTR: History of the First rAAV Vector Product to be Used in Humans. Hum Gene Ther Methods. 2016 Apr; 27(2):49-58.

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Smith EM, Lajoie BR, Jain G, Dekker J. Invariant TAD Boundaries Constrain Cell-Type-Specific Looping Interactions between Promoters and Distal Elements around the CFTR Locus. Am J Hum Genet. 2016 Jan 07; 98(1):185-201.

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O'Sullivan BP. Targeting nonsense-mediated cystic fibrosis: is it premature to stop now? Lancet Respir Med. 2014 Jul; 2(7):509-11.

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Tuggle KL, Birket SE, Cui X, Hong J, Warren J, Reid L, Chambers A, Ji D, Gamber K, Chu KK, Tearney G, Tang LP, Fortenberry JA, Du M, Cadillac JM, Bedwell DM, Rowe SM, Sorscher EJ, Fanucchi MV. Characterization of defects in ion transport and tissue development in cystic fibrosis transmembrane conductance regulator (CFTR)-knockout rats. PLoS One. 2014; 9(3):e91253.

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Figueiras-Fierro D, Acevedo JJ, Mart?nez-L?pez P, Escoffier J, Sep?lveda FV, Balderas E, Orta G, Visconti PE, Darszon A. Electrophysiological evidence for the presence of cystic fibrosis transmembrane conductance regulator (CFTR) in mouse sperm. J Cell Physiol. 2013 Mar; 228(3):590-601.

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