Nucleic Acid Synthesis Inhibitors

"Nucleic Acid Synthesis Inhibitors" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Compounds that inhibit cell production of DNA or RNA.

Descriptor ID	D019384
MeSH Number(s)	D27.505.519.389.675
Concept/Terms	Nucleic Acid Synthesis Inhibitors Nucleic Acid Synthesis Inhibitors Inhibitors, Nucleic Acid Synthesis RNA Synthesis Inhibitors RNA Synthesis Inhibitors Synthesis Inhibitors, RNA Inhibitors, RNA Synthesis DNA Polymerase Inhibitors DNA Polymerase Inhibitors Inhibitors, DNA Polymerase Polymerase Inhibitors, DNA DNA Synthesis Inhibitors DNA Synthesis Inhibitors Synthesis Inhibitors, DNA Inhibitors, DNA Synthesis

Below are MeSH descriptors whose meaning is more general than "Nucleic Acid Synthesis Inhibitors".

Chemicals and Drugs [D]
Chemical Actions and Uses [D27]
Pharmacologic Actions [D27.505]
Molecular Mechanisms of Pharmacological Action [D27.505.519]
Enzyme Inhibitors [D27.505.519.389]
Nucleic Acid Synthesis Inhibitors [D27.505.519.389.675]

Below are MeSH descriptors whose meaning is related to "Nucleic Acid Synthesis Inhibitors".

Below are MeSH descriptors whose meaning is more specific than "Nucleic Acid Synthesis Inhibitors".

Nucleic Acid Synthesis Inhibitors
Reverse Transcriptase Inhibitors

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Nucleic Acid Synthesis Inhibitors" by people in this website by year, and whether "Nucleic Acid Synthesis Inhibitors" was a major or minor topic of these publications.

Bar chart showing 11 publications over 7 distinct years, with a maximum of 2 publications in 2001 and 2002 and 2011 and 2014

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2001	0	2	2
2002	0	2	2
2003	0	1	1
2004	0	1	1
2005	1	0	1
2011	1	1	2
2014	0	2	2

Below are the most recent publications written about "Nucleic Acid Synthesis Inhibitors" by people in Profiles.

Xu WC, Silverman MH, Yu XY, Wright G, Brown N. Discovery and development of DNA polymerase IIIC inhibitors to treat Gram-positive infections. Bioorg Med Chem. 2019 08 01; 27(15):3209-3217.

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Pirkmajer S, Kulkarni SS, Tom RZ, Ross FA, Hawley SA, Hardie DG, Zierath JR, Chibalin AV. Methotrexate promotes glucose uptake and lipid oxidation in skeletal muscle via AMPK activation. Diabetes. 2015 Feb; 64(2):360-9.

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Low PA, Robertson D, Gilman S, Kaufmann H, Singer W, Biaggioni I, Freeman R, Perlman S, Hauser RA, Cheshire W, Lessig S, Vernino S, Mandrekar J, Dupont WD, Chelimsky T, Galpern WR. Efficacy and safety of rifampicin for multiple system atrophy: a randomised, double-blind, placebo-controlled trial. Lancet Neurol. 2014 Mar; 13(3):268-75.

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Dvoskin S, Xu WC, Brown NC, Yanachkov IB, Yanachkova M, Wright GE. A novel agent effective against Clostridium difficile infection. Antimicrob Agents Chemother. 2012 Mar; 56(3):1624-6.

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Bueter CL, Lee CK, Rathinam VAK, Healy GJ, Taron CH, Specht CA, Levitz SM. Chitosan but not chitin activates the inflammasome by a mechanism dependent upon phagocytosis. J Biol Chem. 2011 Oct 14; 286(41):35447-35455.

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Wright GE, Brown NC, Xu WC, Long ZY, Zhi C, Gambino JJ, Barnes MH, Butler MM. Active site directed inhibitors of replication-specific bacterial DNA polymerases. Bioorg Med Chem Lett. 2005 Feb 01; 15(3):729-32.

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Flavahan NA, Bailey SR, Flavahan WA, Mitra S, Flavahan S. Imaging remodeling of the actin cytoskeleton in vascular smooth muscle cells after mechanosensitive arteriolar constriction. Am J Physiol Heart Circ Physiol. 2005 Feb; 288(2):H660-9.

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Furman MI, Krueger LA, Linden MD, Barnard MR, Frelinger AL, Michelson AD. Release of soluble CD40L from platelets is regulated by glycoprotein IIb/IIIa and actin polymerization. J Am Coll Cardiol. 2004 Jun 16; 43(12):2319-25.

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Utaisincharoen P, Kespichayawattana W, Anuntagool N, Chaisuriya P, Pichyangkul S, Krieg AM, Sirisinha S. CpG ODN enhances uptake of bacteria by mouse macrophages. Clin Exp Immunol. 2003 Apr; 132(1):70-5.

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Ganguly BJ, Tonomura N, Benson RM, Osborne BA, Granowitz EV. Hyperbaric oxygen enhances apoptosis in hematopoietic cells. Apoptosis. 2002 Dec; 7(6):499-510.

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