The BRAF oncoprotein functions through the transcriptional repressor MAFG to mediate the CpG Island Methylator phenotype.

Fang M, Ou J, Hutchinson L, Green MR. The BRAF oncoprotein functions through the transcriptional repressor MAFG to mediate the CpG Island Methylator phenotype. Mol Cell. 2014 Sep 18; 55(6):904-915.

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subject areas

Adaptor Proteins, Signal Transducing
Animals
Basic-Leucine Zipper Transcription Factors
Cell Line, Tumor
Colorectal Neoplasms
CpG Islands
DNA (Cytosine-5-)-Methyltransferases
DNA Methylation
DNA-Binding Proteins
Fanconi Anemia Complementation Group Proteins
Gene Expression Regulation, Neoplastic
HEK293 Cells
Humans
MafG Transcription Factor
Mice, Inbred BALB C
Mutation
MutL Protein Homolog 1
Neoplasms, Experimental
Nuclear Proteins
Phenotype
Promoter Regions, Genetic
Proto-Oncogene Proteins B-raf
Repressor Proteins
Signal Transduction
Transcription Factors

authors with profiles

Lloyd Hutchinson PhD
Minggang Fang PhD