 Interleukin-1
"Interleukin-1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A soluble factor produced by MONOCYTES; MACROPHAGES, and other cells which activates T-lymphocytes and potentiates their response to mitogens or antigens. Interleukin-1 is a general term refers to either of the two distinct proteins, INTERLEUKIN-1ALPHA and INTERLEUKIN-1BETA. The biological effects of IL-1 include the ability to replace macrophage requirements for T-cell activation.
| Descriptor ID |
D007375
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| MeSH Number(s) |
D12.644.276.374.465.501 D12.644.276.374.500.400 D12.776.467.374.465.501 D12.776.467.374.500.400 D23.529.374.465.501 D23.529.374.500.400
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| Concept/Terms |
Interleukin-1- Interleukin-1
- Interleukin 1
- IL-1
- T Helper Factor
- Lymphocyte-Activating Factor
- Lymphocyte Activating Factor
- Macrophage Cell Factor
- Epidermal Cell Derived Thymocyte-Activating Factor
- Epidermal Cell Derived Thymocyte Activating Factor
- Interleukin I
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Below are MeSH descriptors whose meaning is more general than "Interleukin-1".
Below are MeSH descriptors whose meaning is more specific than "Interleukin-1".
This graph shows the total number of publications written about "Interleukin-1" by people in this website by year, and whether "Interleukin-1" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1981 | 0 | 1 | 1 | | 1982 | 0 | 2 | 2 | | 1984 | 2 | 0 | 2 | | 1985 | 4 | 0 | 4 | | 1986 | 2 | 1 | 3 | | 1987 | 2 | 1 | 3 | | 1989 | 3 | 2 | 5 | | 1990 | 1 | 0 | 1 | | 1991 | 2 | 1 | 3 | | 1992 | 1 | 0 | 1 | | 1993 | 0 | 2 | 2 | | 1994 | 0 | 2 | 2 | | 1995 | 0 | 2 | 2 | | 1996 | 2 | 3 | 5 | | 1997 | 2 | 3 | 5 | | 1998 | 0 | 3 | 3 | | 1999 | 1 | 3 | 4 | | 2000 | 3 | 2 | 5 | | 2001 | 1 | 3 | 4 | | 2002 | 1 | 6 | 7 | | 2003 | 4 | 4 | 8 | | 2004 | 1 | 4 | 5 | | 2005 | 1 | 3 | 4 | | 2006 | 1 | 2 | 3 | | 2007 | 1 | 3 | 4 | | 2008 | 2 | 1 | 3 | | 2009 | 0 | 3 | 3 | | 2010 | 3 | 3 | 6 | | 2011 | 0 | 1 | 1 | | 2012 | 3 | 4 | 7 | | 2013 | 0 | 2 | 2 | | 2014 | 1 | 1 | 2 | | 2018 | 1 | 0 | 1 |
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Below are the most recent publications written about "Interleukin-1" by people in Profiles.
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Orzalli MH, Smith A, Jurado KA, Iwasaki A, Garlick JA, Kagan JC. An Antiviral Branch of the IL-1 Signaling Pathway Restricts Immune-Evasive Virus Replication. Mol Cell. 2018 09 06; 71(5):825-840.e6.
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Reboldi A, Dang EV, McDonald JG, Liang G, Russell DW, Cyster JG. Inflammation. 25-Hydroxycholesterol suppresses interleukin-1-driven inflammation downstream of type I interferon. Science. 2014 Aug 08; 345(6197):679-84.
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Behar SM, Sassetti CM. Immunology: Fixing the odds against tuberculosis. Nature. 2014 Jul 3; 511(7507):39-40.
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Petrasek J, Csak T, Ganz M, Szabo G. Differences in innate immune signaling between alcoholic and non-alcoholic steatohepatitis. J Gastroenterol Hepatol. 2013 Aug; 28 Suppl 1:93-8.
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Vaine CA, Patel MK, Zhu J, Lee E, Finberg RW, Hayward RC, Kurt-Jones EA. Tuning innate immune activation by surface texturing of polymer microparticles: the role of shape in inflammasome activation. J Immunol. 2013 Apr 1; 190(7):3525-32.
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Szabo G, Petrasek J, Bala S. Innate immunity and alcoholic liver disease. Dig Dis. 2012; 30 Suppl 1:55-60.
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Rock KL, Kataoka H, Lai JJ. Uric acid as a danger signal in gout and its comorbidities. Nat Rev Rheumatol. 2013 Jan; 9(1):13-23.
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Kono H, Orlowski GM, Patel Z, Rock KL. The IL-1-dependent sterile inflammatory response has a substantial caspase-1-independent component that requires cathepsin C. J Immunol. 2012 Oct 1; 189(7):3734-40.
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Janko M, Ontiveros F, Fitzgerald TJ, Deng A, DeCicco M, Rock KL. IL-1 generated subsequent to radiation-induced tissue injury contributes to the pathogenesis of radiodermatitis. Radiat Res. 2012 Sep; 178(3):166-72.
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Grebe A, Latz E. IL-1, quo vadis? Atherosclerosis. 2012 Jun; 222(2):324-5.
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