"Caspases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of intracellular CYSTEINE ENDOPEPTIDASES that play a role in regulating INFLAMMATION and APOPTOSIS. They specifically cleave peptides at a CYSTEINE amino acid that follows an ASPARTIC ACID residue. Caspases are activated by proteolytic cleavage of a precursor form to yield large and small subunits that form the enzyme. Since the cleavage site within precursors matches the specificity of caspases, sequential activation of precursors by activated caspases can occur.
| Descriptor ID |
D020169
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| MeSH Number(s) |
D08.811.277.656.262.500.126 D08.811.277.656.300.200.126 D12.644.360.075.405 D12.776.476.075.405
|
| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Caspases".
Below are MeSH descriptors whose meaning is more specific than "Caspases".
This graph shows the total number of publications written about "Caspases" by people in this website by year, and whether "Caspases" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 1 | 0 | 1 |
| 1998 | 3 | 0 | 3 |
| 1999 | 1 | 1 | 2 |
| 2000 | 3 | 2 | 5 |
| 2001 | 2 | 4 | 6 |
| 2002 | 3 | 8 | 11 |
| 2003 | 5 | 7 | 12 |
| 2004 | 4 | 6 | 10 |
| 2005 | 3 | 9 | 12 |
| 2006 | 4 | 6 | 10 |
| 2007 | 0 | 2 | 2 |
| 2008 | 2 | 5 | 7 |
| 2009 | 3 | 6 | 9 |
| 2010 | 2 | 4 | 6 |
| 2011 | 2 | 2 | 4 |
| 2012 | 3 | 2 | 5 |
| 2013 | 2 | 3 | 5 |
| 2014 | 2 | 4 | 6 |
| 2015 | 1 | 1 | 2 |
| 2016 | 3 | 2 | 5 |
| 2017 | 3 | 1 | 4 |
| 2018 | 2 | 5 | 7 |
| 2020 | 0 | 1 | 1 |
| 2021 | 1 | 1 | 2 |
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click here.
Below are the most recent publications written about "Caspases" by people in Profiles.
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Soni IV, Hardy JA. Caspase-9 Activation of Procaspase-3 but Not Procaspase-6 Is Based on the Local Context of Cleavage Site Motifs and on Sequence. Biochemistry. 2021 09 21; 60(37):2824-2835.
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Lindblad JL, Tare M, Amcheslavsky A, Shields A, Bergmann A. Non-apoptotic enteroblast-specific role of the initiator caspase Dronc for development and homeostasis of the Drosophila intestine. Sci Rep. 2021 01 29; 11(1):2645.
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Humphries F, Shmuel-Galia L, Ketelut-Carneiro N, Li S, Wang B, Nemmara VV, Wilson R, Jiang Z, Khalighinejad F, Muneeruddin K, Shaffer SA, Dutta R, Ionete C, Pesiridis S, Yang S, Thompson PR, Fitzgerald KA. Succination inactivates gasdermin D and blocks pyroptosis. Science. 2020 09 25; 369(6511):1633-1637.
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Nandy A, Lin L, Velentzas PD, Wu LP, Baehrecke EH, Silverman N. The NF-?B Factor Relish Regulates Atg1 Expression and Controls Autophagy. Cell Rep. 2018 11 20; 25(8):2110-2120.e3.
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Doherty J, Baehrecke EH. Life, death and autophagy. Nat Cell Biol. 2018 Oct; 20(10):1110-1117.
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Uetake Y, Sluder G. Activation of the apoptotic pathway during prolonged prometaphase blocks daughter cell proliferation. Mol Biol Cell. 2018 11 01; 29(22):2632-2643.
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Hardy JA. Fighting Kinase Drug Resistance with Caspase Activators. Cell Chem Biol. 2018 08 16; 25(8):927-928.
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Jain R, Frederick JP, Huang EY, Burke KE, Mauger DM, Andrianova EA, Farlow SJ, Siddiqui S, Pimentel J, Cheung-Ong K, McKinney KM, Köhrer C, Moore MJ, Chakraborty T. MicroRNAs Enable mRNA Therapeutics to Selectively Program Cancer Cells to Self-Destruct. Nucleic Acid Ther. 2018 10; 28(5):285-296.
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Amcheslavsky A, Wang S, Fogarty CE, Lindblad JL, Fan Y, Bergmann A. Plasma Membrane Localization of Apoptotic Caspases for Non-apoptotic Functions. Dev Cell. 2018 05 21; 45(4):450-464.e3.
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Eron SJ, MacPherson DJ, Dagbay KB, Hardy JA. Multiple Mechanisms of Zinc-Mediated Inhibition for the Apoptotic Caspases-3, -6, -7, and -8. ACS Chem Biol. 2018 05 18; 13(5):1279-1290.